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Prediction of genetic biomarkers, e.g., microsatellite instability and BRAF in colorectal cancer is crucial for clinical decision making. In this paper, we propose a whole slide image (WSI) based genetic biomarker prediction method via…

Image and Video Processing · Electrical Eng. & Systems 2024-07-16 Ling Zhang , Boxiang Yun , Xingran Xie , Qingli Li , Xinxing Li , Yan Wang

In the field of image classification, existing methods often struggle with biased or ambiguous data, a prevalent issue in real-world scenarios. Current strategies, including semi-supervised learning and class blending, offer partial…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Lars Schmarje , Vasco Grossmann , Claudius Zelenka , Johannes Brünger , Reinhard Koch

Registration is widely used in image-guided therapy and image-guided surgery to estimate spatial correspondences between organs of interest between planning and treatment images. However, while high-quality computed tomography (CT) images…

Image and Video Processing · Electrical Eng. & Systems 2022-03-11 Lin Tian , Connor Puett , Peirong Liu , Zhengyang Shen , Stephen R. Aylward , Yueh Z. Lee , Marc Niethammer

Whole Slide Image (WSI) classification is often formulated as a Multiple Instance Learning (MIL) problem. Recently, Vision-Language Models (VLMs) have demonstrated remarkable performance in WSI classification. However, existing methods…

Computer Vision and Pattern Recognition · Computer Science 2024-04-08 Hao Li , Ying Chen , Yifei Chen , Wenxian Yang , Bowen Ding , Yuchen Han , Liansheng Wang , Rongshan Yu

Image registration is an essential technique for the analysis of Computed Tomography (CT) images in clinical practice. However, existing methodologies are predominantly tailored to a specific organ of interest and often exhibit lower…

Computer Vision and Pattern Recognition · Computer Science 2025-03-31 Xuan Loc Pham , Mathias Prokop , Bram van Ginneken , Alessa Hering

Percutaneous Coronary Intervention (PCI) is a minimally invasive procedure that improves coronary blood flow and treats coronary artery disease. Although PCI typically requires 2D X-ray angiography (XRA) to guide catheter placement at…

Image and Video Processing · Electrical Eng. & Systems 2025-06-02 Peng Qi , Wenxi Qu , Tianliang Yao , Haonan Ma , Dylan Wintle , Yinyi Lai , Giorgos Papanastasiou , Chengjia Wang

Digital pathology has revolutionized the field by enabling the digitization of tissue samples into whole slide images (WSIs). However, the high resolution and large size of WSIs present significant challenges when it comes to applying Deep…

Computer Vision and Pattern Recognition · Computer Science 2025-07-03 Ali Mammadov , Loïc Le Folgoc , Guillaume Hocquet , Pietro Gori

Reliable and accurate registration of patient-specific brain magnetic resonance imaging (MRI) scans containing pathologies is challenging due to tissue appearance changes. This paper describes our contribution to the Registration of the…

Image and Video Processing · Electrical Eng. & Systems 2022-11-22 Ramy A. Zeineldin , Mohamed E. Karar , Franziska Mathis-Ullrich , Oliver Burgert

Registering CT images of the chest is a crucial step for several tasks such as disease progression tracking or surgical planning. It is also a challenging step because of the heterogeneous content of the human abdomen which implies complex…

Computer Vision and Pattern Recognition · Computer Science 2022-10-04 Samuel Joutard , Thomas Pheiffer , Chloe Audigier , Patrick Wohlfahrt , Reuben Dorent , Sebastien Piat , Tom Vercauteren , Marc Modat , Tommaso Mansi

Recent AI navigation approaches aim to improve Whole-Slide Image (WSI) diagnosis by modeling spatial exploration and selecting diagnostically relevant regions, yet most operate at a single fixed magnification or rely on predefined…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Zhengyang Xu , Han Li , Jingsong Liu , Linrui Xie , Xun Ma , Xin You , Shihui Zu , Ayako Ito , Xinyu Hao , Hongming Xu , Shaohua Kevin Zhou , Nassir Navab , Peter J. Schüffler

Whole Slide Images (WSIs) present a challenging computer vision task due to their gigapixel size and presence of numerous artefacts. Yet they are a valuable resource for patient diagnosis and stratification, often representing the gold…

Computer Vision and Pattern Recognition · Computer Science 2023-10-05 Amaya Gallagher-Syed , Luca Rossi , Felice Rivellese , Costantino Pitzalis , Myles Lewis , Michael Barnes , Gregory Slabaugh

Whole slide imaging (WSI) has transformed digital pathology by enabling computational analysis of gigapixel histopathology images. Recent foundation model advances have accelerated progress in computational pathology, facilitating joint…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Peihang Wu , Zehong Chen , Lijian Xu

Ensuring diagnostic performance of AI models before clinical use is key to the safe and successful adoption of these technologies. Studies reporting AI applied to digital pathology images for diagnostic purposes have rapidly increased in…

Nonlinear registration of 2D histological sections with corresponding slices of MRI data is a critical step of 3D histology reconstruction. This task is difficult due to the large differences in image contrast and resolution, as well as the…

Computer Vision and Pattern Recognition · Computer Science 2018-09-28 Juan Eugenio Iglesias , Marc Modat , Loic Peter , Allison Stevens , Roberto Annunziata , Tom Vercauteren , Ed Lein , Bruce Fischl , Sebastien Ourselin

The automatic registration of noninvasive second-harmonic generation microscopy to hematoxylin and eosin slides is a highly desired, yet still unsolved problem. The task is challenging because the second-harmonic images contain only partial…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Marek Wodzinski , Henning Müller

Whole Slide Image (WSI) representation is critical for cancer subtyping, cancer recognition and mutation prediction.Training an end-to-end WSI representation model poses significant challenges, as a standard gigapixel slide can contain tens…

Computer Vision and Pattern Recognition · Computer Science 2025-11-10 Jing Jin , Xu Liu , Te Gao , Zhihong Shi , Yixiong Liang , Ruiqing Zheng , Hulin Kuang , Min Zeng , Shichao Kan

2D to 3D registration is essential in tasks such as diagnosis, surgical navigation, environmental understanding, navigation in robotics, autonomous systems, or augmented reality. In medical imaging, the aim is often to place a 2D image in a…

Computer Vision and Pattern Recognition · Computer Science 2024-10-25 Stefan Brandstätter , Philipp Seeböck , Christoph Fürböck , Svitlana Pochepnia , Helmut Prosch , Georg Langs

Digital pathology is revolutionizing the field of pathology by enabling the digitization, storage, and analysis of tissue samples as whole slide images (WSIs). WSIs are gigapixel files that capture the intricate details of tissue samples,…

Image and Video Processing · Electrical Eng. & Systems 2024-09-10 S. Hemati , Krishna R. Kalari , H. R. Tizhoosh

Recently there have been many algorithms proposed for the classification of very high resolution whole slide images (WSIs). These new algorithms are mostly focused on finding novel ways to combine the information from small local patches…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 Long Nguyen , Aiden Nibali , Joshua Millward , Zhen He

The absence of large-scale masked face datasets challenges masked face detection and recognition. We propose a two-step generative data augmentation framework combining rule-based mask warping with unpaired image-to-image translation via…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Yan Yang , George Bebis , Mircea Nicolescu