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When modeling complex, hierarchical, and time-dynamic systems, such as biological systems, good computational tools are essential. Current tools, while powerful, often lack comprehensive frameworks for modular model composition,…

Quantitative Methods · Quantitative Biology 2025-10-17 Henrik Podéus , Gustav Magnusson , Sasan Keshmiri , Kajsa Tunedal , Nicolas Sundqvist , William Lövfors , Gunnar Cedersund

In traumatic medical emergencies, the patients heavily depend on cranioplasty - the craft of neurocranial repair using cranial implants. Despite the improvements made in recent years, the design of a patient-specific implant (PSI) is among…

Image and Video Processing · Electrical Eng. & Systems 2024-04-25 Michael Lackner , Behrus Puladi , Jens Kleesiek , Jan Egger , Jianning Li

Simulation plays a central role in scientific discovery. In many applications, the bottleneck is no longer running a simulator; it is choosing among large families of plausible simulators, each corresponding to different forward…

Purpose Surgical simulations play an increasingly important role in surgeon education and developing algorithms that enable robots to perform surgical subtasks. To model anatomy, Finite Element Method (FEM) simulations have been held as the…

Robotics · Computer Science 2020-03-27 Jie Ying Wu , Peter Kazanzides , Mathias Unberath

The problem of model selection with a limited number of experimental trials has received considerable attention in cognitive science, where the role of experiments is to discriminate between theories expressed as computational models.…

Machine Learning · Computer Science 2023-03-07 Alexander Aushev , Aini Putkonen , Gregoire Clarte , Suyog Chandramouli , Luigi Acerbi , Samuel Kaski , Andrew Howes

- New advance technologies based on reverse engineering , design and additive manufacturing, have expanded design capabilities for biomedical applications to include Patient Specific Implants (PSI). This change in design paradigms needs…

Medical Physics · Physics 2017-09-21 J. Díaz , Octavio Andrés González-Estrada , C. López

The proliferation of physiological sensors opens new opportunities to explore interactions, conduct experiments and evaluate the user experience with continuous monitoring of bodily functions. Commercial devices, however, can be costly or…

Human-Computer Interaction · Computer Science 2023-09-13 Jitesh Joshi , Katherine Wang , Youngjun Cho

While mastery of neuroanatomy is important for the investigation of the brain, there is an increasing interest in exploring the neural pathways to better understand the roles of neural circuitry in brain functions. To tackle the limitations…

Human-Computer Interaction · Computer Science 2024-02-27 Owen Hellum , Christopher Steele , Yiming Xiao

Optimization time integrators are effective at solving complex multi-physics problems including deformable solids with non-linear material models, contact with friction, strain limiting, etc. For challenging problems, Newton-type optimizers…

Computational Engineering, Finance, and Science · Computer Science 2026-01-01 José Antonio Fernández-Fernández , Fabian Löschner , Lukas Westhofen , Andreas Longva , Jan Bender

A central challenge in many areas of science and engineering is to identify model parameters that are consistent with prior knowledge and empirical data. Bayesian inference offers a principled framework for this task, but can be…

Simulated training platforms offer a suitable avenue for surgical students and professionals to build and improve upon their skills, without the hassle of traditional training methods. To enhance the degree of realistic interaction…

Robotics · Computer Science 2023-08-16 Soroush Sadeghnejad , Mojtaba Esfandiari , Farshad Khadivar

Virtual models are important for training and teaching tools used in medical imaging research. We introduce a workflow that can be used to convert volumetric medical imaging data (as generated by Computer Tomography (CT)) to computer-based…

Medical Physics · Physics 2024-02-05 Kaustav Bora , Adarsh Mishra , CS Kumar

Self-supervised learning (SSL) leverages vast unannotated medical datasets, yet steep technical barriers limit adoption by clinical researchers. We introduce Vision Foundry, a code-free, HIPAA-compliant platform that democratizes…

The concept and synthesis approach for planar Compliant Fluidic Control Structures (CFCSs), monolithic flexible continua with embedded functional pores, is presented in this manuscript. Such structures are envisioned to find application in…

Computational Engineering, Finance, and Science · Computer Science 2019-04-22 Prabhat Kumar , Paola Fanzio , Luigi Sasso , Matthijs Langelaar

Many cytoskeletal systems are now sufficiently well known to permit their precise quantitative modelling. Microtubule and actin filaments are well characterized, and the associated proteins are often known, as well as their abundance and…

Quantitative Methods · Quantitative Biology 2022-05-30 Carlos A. Lugo , Eashan Saikia , Francois Nedelec

This paper tackles the challenge of automatically performing realistic surgical simulations from readily available surgical videos. Recent efforts have successfully integrated physically grounded dynamics within 3D Gaussians to perform…

Computer Vision and Pattern Recognition · Computer Science 2024-12-04 Kailing Wang , Chen Yang , Keyang Zhao , Xiaokang Yang , Wei Shen

Robot-assisted neurological surgery is receiving growing interest due to the improved dexterity, precision, and control of surgical tools, which results in better patient outcomes. However, such systems often limit surgeons' natural sensory…

Signal Processing · Electrical Eng. & Systems 2025-08-13 Zacharias Chen , Alexa Cristelle Cahilig , Sarah Dias , Prithu Kolar , Ravi Prakash , Patrick J. Codd

Computational models of how users perceive and act within a virtual or physical environment offer enormous potential for the understanding and design of user interactions. Cognition models have been used to understand the role of attention…

Background and Objective: Computational ultrasound imaging has become a well-established methodology in the ultrasound community. Simulations of ultrasound sequences and images allow the study of innovative techniques in terms of emission…

Medical Physics · Physics 2022-03-08 Damien Garcia

Robotic-assisted surgery offers significant clinical advantages but largely eliminates direct haptic feedback, increasing the risk of excessive tool-tissue interaction forces. Although recent commercial systems have begun to introduce force…

Robotics · Computer Science 2026-05-01 Walid Shaker , Mustafa Suphi Erden