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Nuclei segmentation is the cornerstone task in histology image reading, shedding light on the underlying molecular patterns and leading to disease or cancer diagnosis. Yet, it is a laborious task that requires expertise from trained…

Image and Video Processing · Electrical Eng. & Systems 2025-11-10 Vasileios Magoulianitis , Catherine A. Alexander , Jiaxin Yang , C. -C. Jay Kuo

We propose a 3D convolutional neural network to simultaneously segment and detect cell nuclei in confocal microscopy images. Mirroring the co-dependency of these tasks, our proposed model consists of two serial components: the first part…

Image and Video Processing · Electrical Eng. & Systems 2018-09-07 Sundaresh Ram , Vicky T. Nguyen , Kirsten H. Limesand , Mert R. Sabuncu

Despite the success of deep learning methods in medical image segmentation tasks, the human-level performance relies on massive training data with high-quality annotations, which are expensive and time-consuming to collect. The fact is that…

Computer Vision and Pattern Recognition · Computer Science 2021-06-22 Jialin Shi , Ji Wu

We propose a novel approach to automatically tracking cell populations in time-lapse images. To account for cell occlusions and overlaps, we introduce a robust method that generates an over-complete set of competing detection hypotheses. We…

Computer Vision and Pattern Recognition · Computer Science 2016-01-27 Engin Türetken , Xinchao Wang , Carlos Becker , Carsten Haubold , Pascal Fua

Cell detection is an essential task in cell image analysis. Recent deep learning-based detection methods have achieved very promising results. In general, these methods require exhaustively annotating the cells in an entire image. If some…

Computer Vision and Pattern Recognition · Computer Science 2021-07-22 Kazuma Fujii , Daiki Suehiro , Kazuya Nishimura , Ryoma Bise

Fully convolutional networks (FCN) have achieved great success in human parsing in recent years. In conventional human parsing tasks, pixel-level labeling is required for guiding the training, which usually involves enormous human labeling…

Computer Vision and Pattern Recognition · Computer Science 2018-09-17 Zhonghua Wu , Guosheng Lin , Jianfei Cai

Weakly supervised segmentation methods can delineate thyroid nodules in ultrasound images efficiently using training data with coarse labels, but suffer from: 1) low-confidence pseudo-labels that follow topological priors, introducing…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Jianning Chi , Zelan Li , Geng Lin , MingYang Sun , Xiaosheng Yu

Human skin segmentation is a crucial task in computer vision and biometric systems, yet it poses several challenges such as variability in skin color, pose, and illumination. This paper presents a robust data-driven skin segmentation method…

Computer Vision and Pattern Recognition · Computer Science 2023-02-10 Kooshan Hashemifard , Pau Climent-Perez , Francisco Florez-Revuelta

We propose a general framework for a collaborative machine learning system to assist bioscience researchers with the task of labeling specific cell identities from microscopic still or video imaging. The distinguishing features of this…

Quantitative Methods · Quantitative Biology 2019-03-25 Greg Bubnis , Steven Ban , Matthew D. DiFranco , Saul Kato

Cell detection and tracking are paramount for bio-analysis. Recent approaches rely on the tracking-by-model evolution paradigm, which usually consists of training end-to-end deep learning models to detect and track the cells on the frames…

Computer Vision and Pattern Recognition · Computer Science 2023-10-12 Lucas N. Kirsten , Cláudio R. Jung

Counting cells in fluorescent microscopy is a tedious, time-consuming task that researchers have to accomplish to assess the effects of different experimental conditions on biological structures of interest. Although such objects are…

Computer Vision and Pattern Recognition · Computer Science 2021-03-02 R. Morelli , L. Clissa , M. Dalla , M. Luppi , L. Rinaldi , A. Zoccoli

Deep learning provides us with powerful methods to perform nucleus or cell segmentation with unprecedented quality. However, these methods usually require large training sets of manually annotated images, which are tedious and expensive to…

Image and Video Processing · Electrical Eng. & Systems 2023-01-11 Thomas Bonte , Maxence Philbert , Emeline Coleno , Edouard Bertrand , Arthur Imbert , Thomas Walter

In many applications, training machine learning models involves using large amounts of human-annotated data. Obtaining precise labels for the data is expensive. Instead, training with weak supervision provides a low-cost alternative. We…

Machine Learning · Computer Science 2022-02-09 Chidubem Arachie , Bert Huang

Despite deep convolutional neural networks boost the performance of image classification and segmentation in digital pathology analysis, they are usually weak in interpretability for clinical applications or require heavy annotations to…

Computer Vision and Pattern Recognition · Computer Science 2020-02-10 Yongxiang Huang , Albert C. S. Chung

Cell classification and counting in immunohistochemical cytoplasm staining images play a pivotal role in cancer diagnosis. Weakly supervised learning is a potential method to deal with labor-intensive labeling. However, the inconstant cell…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Shichuan Zhang , Chenglu Zhu , Honglin Li , Jiatong Cai , Lin Yang

Although existing semantic segmentation approaches achieve impressive results, they still struggle to update their models incrementally as new categories are uncovered. Furthermore, pixel-by-pixel annotations are expensive and…

Computer Vision and Pattern Recognition · Computer Science 2022-04-04 Fabio Cermelli , Dario Fontanel , Antonio Tavera , Marco Ciccone , Barbara Caputo

Automatic detection and segmentation of cells and nuclei in microscopy images is important for many biological applications. Recent successful learning-based approaches include per-pixel cell segmentation with subsequent pixel grouping, or…

Computer Vision and Pattern Recognition · Computer Science 2018-11-09 Uwe Schmidt , Martin Weigert , Coleman Broaddus , Gene Myers

This work aims to leverage pre-trained foundation models, such as contrastive language-image pre-training (CLIP) and segment anything model (SAM), to address weakly supervised semantic segmentation (WSSS) using image-level labels. To this…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Xiaobo Yang , Xiaojin Gong

In this paper, we study weakly-supervised laparoscopic image segmentation with sparse annotations. We introduce a novel Bayesian deep learning approach designed to enhance both the accuracy and interpretability of the model's segmentation,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-14 Zhou Zheng , Yuichiro Hayashi , Masahiro Oda , Takayuki Kitasaka , Kensaku Mori

Recently deep learning has been witnessing widespread adoption in various medical image applications. However, training complex deep neural nets requires large-scale datasets labeled with ground truth, which are often unavailable in many…

Computer Vision and Pattern Recognition · Computer Science 2018-05-29 Wentao Zhu , Yeeleng S. Vang , Yufang Huang , Xiaohui Xie