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Traditionally, optimization of radiation therapy (RT) treatment plans has been done before the initiation of RT course, using population-wide estimates for patients' response to therapy. However, recent technological advancements have…

Medical Physics · Physics 2021-02-15 Stefan C. M. ten Eikelder , Ali Ajdari , Thomas Bortfeld , Dick den Hertog

This paper proposes group-based distributed optimization (DO) algorithms on top of intelligent partitioning for the optimal power flow (OPF) problems. Radial partitioning of the graph of a network is introduced as a systematic way to split…

Optimization and Control · Mathematics 2024-08-07 Mehdi Karimi

This paper addresses a distributed optimization problem in a communication network where nodes are active sporadically. Each active node applies some learning method to control its action to maximize the global utility function, which is…

Optimization and Control · Mathematics 2021-04-20 Wenjie Li , Mohamad Assaad , Shiqi Zheng

Time distributed optimization is an implementation strategy that can significantly reduce the computational burden of model predictive control by exploiting its robustness to incomplete optimization. When using this strategy, optimization…

Optimization and Control · Mathematics 2020-04-14 Dominic Liao-McPherson , Marco Nicotra , Ilya Kolmanovsky

The advent of ultra-high dose rate irradiation, known as FLASH radiation therapy, has shown promising potential in reducing toxicity while maintaining tumor control. However, the clinical translation of these benefits necessitates efficient…

Medical Physics · Physics 2024-09-19 Viktor Wase , Oscar Widenfalk , Rasmus Nilsson , Claes Fälth , Albin Fredriksson

Radiation therapy treatment planning can be viewed as an iterative hyperparameter tuning process to balance conflicting clinical goals. In this work, we investigated the performance of modern Bayesian Optimization (BO) methods on automated…

Medical Physics · Physics 2023-02-15 Qingying Wang , Ruoxi Wang , Jiacheng Liu , Fan Jiang , Haizhen Yue , Yi Du , Hao Wu

In modern large-scale systems with sensor networks and IoT devices it is essential to collaboratively solve complex problems while utilizing network resources efficiently. In our paper we present three distributed optimization algorithms…

Systems and Control · Electrical Eng. & Systems 2025-04-24 Apostolos I. Rikos , Wei Jiang , Themistoklis Charalambous , Karl H. Johansson

We present a distributed optimization algorithm for solving online personalized optimization problems over a network of computing and communicating nodes, each of which linked to a specific user. The local objective functions are assumed to…

Systems and Control · Electrical Eng. & Systems 2021-04-15 Ivano Notarnicola , Andrea Simonetto , Francesco Farina , Giuseppe Notarstefano

With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…

Medical Physics · Physics 2018-12-03 Dan Nguyen , Troy Long , Xun Jia , Weiguo Lu , Xuejun Gu , Zohaib Iqbal , Steve Jiang

In this paper, we study the problem of distributed multi-agent optimization over a network, where each agent possesses a local cost function that is smooth and strongly convex. The global objective is to find a common solution that…

Optimization and Control · Mathematics 2019-08-02 Shi Pu , Angelia Nedić

A novel method is presented and explored within the framework of Potts neural networks for solving optimization problems with a non-trivial topology, with the airline crew scheduling problem as a target application. The key ingredient to…

Disordered Systems and Neural Networks · Physics 2016-08-15 M. Lagerholm , C. Peterson , B. Söderberg

One primary goal of precision medicine is to estimate the individualized treatment rules (ITRs) that optimize patients' health outcomes based on individual characteristics. Health studies with multiple treatments are commonly seen in…

Methodology · Statistics 2025-05-07 Xuqiao Li , Qiuyan Zhou , Ying Wu , Ying Yan

We study the distributed stochastic compositional optimization problems over directed communication networks in which agents privately own a stochastic compositional objective function and collaborate to minimize the sum of all objective…

Optimization and Control · Mathematics 2022-03-22 Shengchao Zhao , Yongchao Liu

This thesis explores a particular class of distributed optimization methods for various separable resource allocation problems, which are of high interest in a wide array of multi-agent settings. A distinctly motivating application for this…

Systems and Control · Electrical Eng. & Systems 2021-03-26 Tor Anderson

Optimal power flow (OPF) is an important problem for power generation and it is in general non-convex. With the employment of renewable energy, it will be desirable if OPF can be solved very efficiently so its solution can be used in real…

Optimization and Control · Mathematics 2011-09-27 Albert Y. S. Lam , Baosen Zhang , David Tse

We propose a hierarchical distributed algorithm to solve optimal power flow (OPF) problems that aim at dispatching controllable distributed energy resources (DERs) for voltage regulation at minimum cost. The proposed algorithm features…

Optimization and Control · Mathematics 2020-02-10 Xinyang Zhou , Zhiyuan Liu , Changhong Zhao , Lijun Chen

The widespread adoption of on-board volumetric imaging in cancer radiotherapy has stimulated research efforts to develop online adaptive radiotherapy techniques to handle the inter-fraction variation of the patient's geometry. Such efforts…

Medical Physics · Physics 2015-05-14 Chunhua Men , Xuejun Gu , Dongju Choi , Amitava Majumdar , Ziyi Zheng , Klaus Mueller , Steve B. Jiang

The predicted increase in the number of patients receiving radiation therapy (RT) to treat cancer calls for an optimized use of resources. To manually schedule patients on the linear accelerators delivering RT is a time-consuming and…

Optimization and Control · Mathematics 2023-03-29 Sara Frimodig , Carole Mercier , Geert De Kerf

Solving optimal power flow (OPF) problems for large distribution networks incurs high computational complexity. We consider a large multi-phase distribution network of tree topology with a deep penetration of active devices. We divide the…

Optimization and Control · Mathematics 2020-09-10 Xinyang Zhou , Yue Chen , Zhiyuan Liu , Changhong Zhao , Lijun Chen

We consider the effects of parameter uncertainty on the optimal radiation schedule in the context of the linear-quadratic model. Our interest arises from the observation that if inter-patient variations in OAR and tumor sensitivities to…

Tissues and Organs · Quantitative Biology 2015-06-05 Hamidreza Badri , Yoichi Watanabe , Kevin Leder
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