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Deep learning survival models often outperform classical methods in time-to-event predictions, particularly in personalized medicine, but their "black box" nature hinders broader adoption. We propose a framework for gradient-based…

Machine Learning · Statistics 2025-02-10 Sophie Hanna Langbein , Niklas Koenen , Marvin N. Wright

With the adoption of machine learning into routine clinical practice comes the need for Explainable AI methods tailored to medical applications. Shapley values have sparked wide interest for locally explaining models. Here, we demonstrate…

Machine Learning · Computer Science 2024-02-02 Lucile Ter-Minassian , Sahra Ghalebikesabi , Karla Diaz-Ordaz , Chris Holmes

A trustworthy machine learning model should be accurate as well as explainable. Understanding why a model makes a certain decision defines the notion of explainability. While various flavors of explainability have been well-studied in…

Hazard and survival functions are natural, interpretable targets in time-to-event prediction, but their inherent non-additivity fundamentally limits standard additive explanation methods. We introduce Survival Functional Decomposition…

Survival analysis is a hotspot in statistical research for modeling time-to-event information with data censorship handling, which has been widely used in many applications such as clinical research, information system and other fields with…

Machine Learning · Computer Science 2018-11-14 Kan Ren , Jiarui Qin , Lei Zheng , Zhengyu Yang , Weinan Zhang , Lin Qiu , Yong Yu

Survival analysis, a foundational tool for modeling time-to-event data, has seen growing integration with machine learning (ML) approaches to handle the complexities of censored data and time-varying risks. Despite these advances,…

Quantitative Methods · Quantitative Biology 2025-02-05 Giovanni Birolo , Ivan Rossi , Flavio Sartori , Cesare Rollo , Tiziana Sanavia , Piero Fariselli

Time-to-event prediction, e.g. cancer survival analysis or hospital length of stay, is a highly prominent machine learning task in medical and healthcare applications. However, only a few interpretable machine learning methods comply with…

Computer Vision and Pattern Recognition · Computer Science 2024-11-25 Hubert Baniecki , Bartlomiej Sobieski , Patryk Szatkowski , Przemyslaw Bombinski , Przemyslaw Biecek

Unpacking and comprehending how black-box machine learning algorithms make decisions has been a persistent challenge for researchers and end-users. Explaining time-series predictive models is useful for clinical applications with high…

Machine Learning · Computer Science 2023-05-09 Amin Nayebi , Sindhu Tipirneni , Chandan K Reddy , Brandon Foreman , Vignesh Subbian

Survival Regression (SuR) is a key technique for modeling time to event in important applications such as clinical trials and semiconductor manufacturing. Currently, SuR algorithms belong to one of three classes: non-linear black-box --…

Machine Learning · Computer Science 2025-04-09 Luigi Rovito , Marco Virgolin

Survival analysis, or time-to-event analysis, is an important and widespread problem in healthcare research. Medical research has traditionally relied on Cox models for survival analysis, due to their simplicity and interpretability. Cox…

Machine Learning · Computer Science 2023-10-25 Mike Van Ness , Tomas Bosschieter , Natasha Din , Andrew Ambrosy , Alexander Sandhu , Madeleine Udell

Score-based explainable machine-learning techniques are often used to understand the logic behind black-box models. However, such explanation techniques are often computationally expensive, which limits their application in time-critical…

Machine Learning · Computer Science 2023-08-24 Amr Alkhatib , Henrik Boström , Sofiane Ennadir , Ulf Johansson

A new modification of the Neural Additive Model (NAM) called SurvNAM and its modifications are proposed to explain predictions of the black-box machine learning survival model. The method is based on applying the original NAM to solving the…

Machine Learning · Computer Science 2021-04-20 Lev V. Utkin , Egor D. Satyukov , Andrei V. Konstantinov

Data preprocessing is often paid little attention in machine learning, despite its potentially significant impact on model performance. While automated machine learning pipelines are starting to recognize and integrate data preprocessing…

Machine Learning · Computer Science 2026-05-27 Yousef Koka , David Selby , Gerrit Großmann , Kathan Pandya , Sebastian Vollmer

Despite the high performance of neural network-based time series forecasting methods, the inherent challenge in explaining their predictions has limited their applicability in certain application areas. Due to the difficulty in identifying…

Machine Learning · Computer Science 2023-01-09 Ozan Ozyegen , Juyoung Wang , Mucahit Cevik

Accurately predicting the time of occurrence of an event of interest is a critical problem in longitudinal data analysis. One of the main challenges in this context is the presence of instances whose event outcomes become unobservable after…

Machine Learning · Computer Science 2017-12-26 Ping Wang , Yan Li , Chandan K. Reddy

Due to their flexibility and superior performance, machine learning models frequently complement and outperform traditional statistical survival models. However, their widespread adoption is hindered by a lack of user-friendly tools to…

Accurate and transparent prediction of cancer survival times on the level of individual patients can inform and improve patient care and treatment practices. In this paper, we design a model that concurrently learns to accurately predict…

Machine Learning · Computer Science 2018-01-31 Maruan Al-Shedivat , Avinava Dubey , Eric P. Xing

In this growing age of data and technology, large black-box models are becoming the norm due to their ability to handle vast amounts of data and learn incredibly complex data patterns. The deficiency of these methods, however, is their…

Machine Learning · Computer Science 2026-04-09 Justin Lin , Julia Fukuyama

Models in the supervised learning framework may capture rich and complex representations over the features that are hard for humans to interpret. Existing methods to explain such models are often specific to architectures and data where the…

Machine Learning · Computer Science 2021-02-25 Akshay Sood , Mark Craven

In this paper we present SurvLIMEpy, an open-source Python package that implements the SurvLIME algorithm. This method allows to compute local feature importance for machine learning algorithms designed for modelling Survival Analysis data.…

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