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The success of deep learning has set new benchmarks for many medical image analysis tasks. However, deep models often fail to generalize in the presence of distribution shifts between training (source) data and test (target) data. One…

Image and Video Processing · Electrical Eng. & Systems 2022-06-28 Dwarikanath Mahapatra

In this paper, we address domain shifts in pathological images by focusing on shifts within whole slide images~(WSIs), such as patient characteristics and tissue thickness, rather than shifts between hospitals. Traditional approaches rely…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Yuki Shigeyasu , Shota Harada , Akihiko Yoshizawa , Kazuhiro Terada , Naoki Nakazima , Mariyo Kurata , Hiroyuki Abe , Tetsuo Ushiku , Ryoma Bise

Deep learning-based methods deliver state-of-the-art performance for solving inverse problems that arise in computational imaging. These methods can be broadly divided into two groups: (1) learn a network to map measurements to the signal…

Image and Video Processing · Electrical Eng. & Systems 2023-10-11 Nebiyou Yismaw , Ulugbek S. Kamilov , M. Salman Asif

Deep learning models have revolutionized the field of medical image analysis, due to their outstanding performances. However, they are sensitive to spurious correlations, often taking advantage of dataset bias to improve results for…

Computer Vision and Pattern Recognition · Computer Science 2024-05-06 Diogo J. Araújo , M. Rita Verdelho , Alceu Bissoto , Jacinto C. Nascimento , Carlos Santiago , Catarina Barata

Medical image registration and segmentation are critical tasks for several clinical procedures. Manual realisation of those tasks is time-consuming and the quality is highly dependent on the level of expertise of the physician. To mitigate…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Lihao Liu , Zhening Huang , Pietro Liò , Carola-Bibiane Schönlieb , Angelica I. Aviles-Rivero

Histopathology remains the gold standard for diagnosis of various cancers. Recent advances in computer vision, specifically deep learning, have facilitated the analysis of histopathology images for various tasks, including immune cell…

Quantitative Methods · Quantitative Biology 2023-11-02 Jakub R. Kaczmarzyk , Tahsin M. Kurc , Shahira Abousamra , Rajarsi Gupta , Joel H. Saltz , Peter K. Koo

Understanding how a complex machine learning model makes a classification decision is essential for its acceptance in sensitive areas such as health care. Towards this end, we present PatchNet, a method that provides the features indicative…

Computer Vision and Pattern Recognition · Computer Science 2018-12-03 Adityanarayanan Radhakrishnan , Charles Durham , Ali Soylemezoglu , Caroline Uhler

Colorectal diseases, including inflammatory conditions and neoplasms, require quick, accurate care to be effectively treated. Traditional diagnostic pipelines require extensive preparation and rely on separate, individual evaluations on…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Krithik Ramesh , Ritvik Koneru

Virtual immunohistochemistry (IHC) aims to computationally synthesize molecular staining patterns from routine Hematoxylin and Eosin (H\&E) images, offering a cost-effective and tissue-efficient alternative to traditional physical staining.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-23 Rongze Ma , Mengkang Lu , Zhenyu Xiang , Yongsheng Pan , Yicheng Wu , Qingjie Zeng , Yong Xia

Emerging diseases present challenges in symptom recognition and timely clinical intervention due to limited available information. An effective prognostic model could assist physicians in making accurate diagnoses and designing personalized…

Machine Learning · Computer Science 2025-02-12 Zhongji Zhang , Yuhang Wang , Yinghao Zhu , Xinyu Ma , Yasha Wang , Junyi Gao , Liantao Ma , Wen Tang , Xiaoyun Zhang , Ling Wang

Domain generalization in computational histopathology is hindered by heterogeneity in whole slide images (WSIs), caused by variations in tissue preparation, staining, and imaging conditions across institutions. Unlike machine learning…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Hikmat Khan , Syed Farhan Alam Zaidi , Pir Masoom Shah , Kiruthika Balakrishnan , Rabia Khan , Muhammad Waqas , Jia Wu

Preparing and scanning histopathology slides consists of several steps, each with a multitude of parameters. The parameters can vary between pathology labs and within the same lab over time, resulting in significant variability of the…

Computer Vision and Pattern Recognition · Computer Science 2018-01-11 Maxime W. Lafarge , Josien P. W. Pluim , Koen A. J. Eppenhof , Pim Moeskops , Mitko Veta

Deep learning models for dermatological image analysis remain sensitive to acquisition variability and domain-specific visual characteristics, leading to performance degradation when deployed in clinical settings. We investigate how visual…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Rodrigo Mota , Kelvin Cunha , Emanoel dos Santos , Fábio Papais , Francisco Filho , Thales Bezerra , Erico Medeiros , Paulo Borba , Tsang Ing Ren

Contrastive pretraining can substantially increase model generalisation and downstream performance. However, the quality of the learned representations is highly dependent on the data augmentation strategy applied to generate positive…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Mélanie Roschewitz , Fabio De Sousa Ribeiro , Tian Xia , Galvin Khara , Ben Glocker

Face anti-spoofing techniques based on domain generalization have recently been studied widely. Adversarial learning and meta-learning techniques have been adopted to learn domain-invariant representations. However, prior approaches often…

Computer Vision and Pattern Recognition · Computer Science 2024-07-12 Jingyi Yang , Zitong Yu , Xiuming Ni , Jia He , Hui Li

This work addresses how to efficiently classify challenging histopathology images, such as gigapixel whole-slide images for cancer diagnostics with image-level annotation. We use images with annotated tumor regions to identify a set of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Mohammad Iqbal Nouyed , Mary-Anne Hartley , Gianfranco Doretto , Donald A. Adjeroh

Domain shift, the mismatch between training and testing data characteristics, causes significant degradation in the predictive performance in multi-source imaging scenarios. In medical imaging, the heterogeneity of population, scanners and…

Machine Learning · Computer Science 2021-12-21 Rongguang Wang , Pratik Chaudhari , Christos Davatzikos

Traditional domain generalization methods often rely on domain alignment to reduce inter-domain distribution differences and learn domain-invariant representations. However, domain shifts are inherently difficult to eliminate, which limits…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Yuheng Xu , Taiping Zhang

In this work, we tackle the challenging problem of arbitrary image style transfer using a novel style feature representation learning method. A suitable style representation, as a key component in image stylization tasks, is essential to…

Computer Vision and Pattern Recognition · Computer Science 2022-11-08 Yuxin Zhang , Fan Tang , Weiming Dong , Haibin Huang , Chongyang Ma , Tong-Yee Lee , Changsheng Xu

In computer vision, data shift has proven to be a major barrier for safe and robust deep learning applications. In medical applications, histopathological images are often associated with data shift and they are hardly available. It is…

Computer Vision and Pattern Recognition · Computer Science 2022-01-25 Nicolas Dumas , Valentin Derangère , Laurent Arnould , Sylvain Ladoire , Louis-Oscar Morel , Nathan Vinçon