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Protein interaction networks (PIN) are popular means to visualize the proteome. However, PIN datasets are known to be noisy, incomplete and biased by the experimental protocols used to detect protein interactions. This paper aims at…

Disordered Systems and Neural Networks · Physics 2015-01-06 Alessia Annibale , Anthony C. C. Coolen , Nuria Planell-Morell

Genome-wide protein-protein interaction (PPI) data are readily available thanks to recent breakthroughs in biotechnology. However, PPI networks of extant organisms are only snapshots of the network evolution. How to infer the whole…

Populations and Evolution · Quantitative Biology 2012-03-13 Si Li , Kwok Pui Choi , Taoyang Wu , Louxin Zhang

Aberrant protein-protein interactions (PPIs) underpin a plethora of human diseases, and disruption of these harmful interactions constitute a compelling treatment avenue. Advances in computational approaches to PPI prediction have closely…

Biomolecules · Quantitative Biology 2025-07-29 François Charih , James R. Green , Kyle K. Biggar

Predicting protein-protein interactions (PPIs) by learning informative representations from amino acid sequences is a challenging yet important problem in biology. Although various deep learning models in Siamese architecture have been…

Machine Learning · Computer Science 2020-10-19 Kishan KC , Feng Cui , Anne Haake , Rui Li

Many protein-protein interaction (PPI) networks take place in the fluid yet structured plasma membrane. Lipid domains, sometimes termed rafts, have been implicated in the functioning of various membrane-bound signaling processes. Here, we…

Biological Physics · Physics 2025-11-03 Taylor Schaffner , Benjamin B. Machta

Random walks are fundamental models of stochastic processes with applications in various fields including physics, biology, and computer science. We study classical and quantum random walks under the influence of stochastic resetting on…

Statistical Mechanics · Physics 2021-01-20 Sascha Wald , Lucas Böttcher

Full control over the dynamics of interacting, indistinguishable quantum particles is an important prerequisite for the experimental study of strongly correlated quantum matter and the implementation of high-fidelity quantum information…

Protein-protein interactions (PPIs) are crucial in various biological processes and their study has significant implications for drug development and disease diagnosis. Existing deep learning methods suffer from significant performance…

Molecular Networks · Quantitative Biology 2023-05-16 Ziyuan Zhao , Peisheng Qian , Xulei Yang , Zeng Zeng , Cuntai Guan , Wai Leong Tam , Xiaoli Li

Dynamic networks have intrinsic structural, computational, and multidisciplinary advantages. Link prediction estimates the next relationship in dynamic networks. However, in the current link prediction approaches, only bipartite or…

Social and Information Networks · Computer Science 2020-06-09 Mohamoud Ali , Yugyung Lee , Praveen Rao

It has been claimed that protein-protein interaction (PPI) networks are scale-free based on the observation that the node degree sequence follows a power law. Here we argue that these claims are likely to be based on erroneous statistical…

Molecular Networks · Quantitative Biology 2007-05-23 Reiko Tanaka , Tau-Mu Yi , John Doyle

In this work, Transition Probability Matrix (TPM) is proposed as a new method for extracting the features of nodes in the graph. The proposed method uses random walks to capture the connectivity structure of a node's close neighborhood. The…

Machine Learning · Computer Science 2023-03-07 Sarmad N. Mohammed , Semra Gündüç

Biological networks provide insight into the complex organization of biological processes in a cell at the system level. They are an effective tool for understanding the comprehensive map of functional interactions, finding the functional…

Molecular Networks · Quantitative Biology 2017-09-14 Somaye Hashemifar

A new model of quantum random walks is introduced, on lattices as well as on finite graphs. These quantum random walks take into account the behavior of open quantum systems. They are the exact quantum analogues of classical Markov chains.…

Quantum Physics · Physics 2014-02-14 S. Attal , F. Petruccione , C. Sabot , I. Sinayskiy

Background. Human aging is linked to many prevalent diseases. The aging process is highly influenced by genetic factors. Hence, it is important to identify human aging-related genes. We focus on supervised prediction of such genes. Gene…

Molecular Networks · Quantitative Biology 2020-04-28 Qi Li , Tijana Milenković

Understanding how molecular alterations propagate across biological systems to drive disease remains a central challenge. Although high-throughput profiling enables comprehensive characterization of tumor states, most models neglect…

Quantitative Methods · Quantitative Biology 2026-05-11 Kyle Higgins , Guadalupe Gonzalez , Dennis Veselkov , Ivan Laponogov , Kirill Veselkov

The identification of compound-protein interactions (CPI) plays a critical role in drug screening, drug repurposing, and combination therapy studies. The effectiveness of CPI prediction relies heavily on the features extracted from both…

Biomolecules · Quantitative Biology 2023-06-16 Li Zhang , Wenhao Li , Haotian Guan , Zhiquan He , Mingjun Cheng , Han Wang

Inspired by practical importance of social networks, economic networks, biological networks and so on, studies on large and complex networks have attracted a surge of attentions in the recent years. Link prediction is a fundamental issue to…

Social and Information Networks · Computer Science 2017-04-05 Ratha Pech , Dong Hao , Liming Pan , Hong Cheng , Tao Zhou

We develop a path-based approach to continuous-time random walks on networks with arbitrarily weighted edges. We describe an efficient numerical algorithm for calculating statistical properties of the stochastic path ensemble. After…

Populations and Evolution · Quantitative Biology 2014-08-19 Michael Manhart , Alexandre V. Morozov

Link-prediction is an active research field within network theory, aiming at uncovering missing connections or predicting the emergence of future relationships from the observed network structure. This paper represents our contribution to…

Physics and Society · Physics 2018-07-20 Federica Parisi , Guido Caldarelli , Tiziano Squartini

Accurately predicting complex protein-protein interactions (PPIs) is crucial for decoding biological processes, from cellular functioning to disease mechanisms. However, experimental methods for determining PPIs are computationally…