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We address the problem of single photo age progression and regression-the prediction of how a person might look in the future, or how they looked in the past. Most existing aging methods are limited to changing the texture, overlooking…

Computer Vision and Pattern Recognition · Computer Science 2020-07-27 Roy Or-El , Soumyadip Sengupta , Ohad Fried , Eli Shechtman , Ira Kemelmacher-Shlizerman

Structural and appearance changes in brain imaging over time are crucial indicators of neurodevelopment and neurodegeneration. The rapid advancement of large-scale generative models provides a promising backbone for modeling these complex…

Graphics · Computer Science 2025-03-14 Gexin Huang , Zhangsihao Yang , Yalin Wang , Guido Gerig , Mengwei Ren , Xiaoxiao Li

Understanding how decision making changes across the lifespan is a central challenge for neuroscience, yet research on cognitive aging has remained largely disconnected from the theoretical and computational advances that now shape modern…

Neurons and Cognition · Quantitative Biology 2026-03-04 Michael B. Ryan , Letizia Ye , Anne K. Churchland

Predicting future disease progression risk from medical images is challenging due to patient heterogeneity, and subtle or unknown imaging biomarkers. Moreover, deep learning (DL) methods for survival analysis are susceptible to image domain…

With the rapid development of artificial intelligence (AI), digital humans have attracted more and more attention and are expected to achieve a wide range of applications in several industries. Then, most of the existing digital humans…

Multimedia · Computer Science 2023-11-01 Yingjie Zhou , Yaodong Chen , Kaiyue Bi , Lian Xiong , Hui Liu

Cardiac digital twins are computational tools capturing key functional and anatomical characteristics of patient hearts for investigating disease phenotypes and predicting responses to therapy. When paired with large-scale computational…

Computational Engineering, Finance, and Science · Computer Science 2024-01-19 Julia Camps , Zhinuo Jenny Wang , Ruben Doste , Maxx Holmes , Brodie Lawson , Jakub Tomek , Kevin Burrage , Alfonso Bueno-Orovio , Blanca Rodriguez

Digital twins (DT) are often defined as a pairing of a physical entity and a corresponding virtual entity (VE), mimicking certain aspects of the former depending on the use-case. In recent years, this concept has facilitated numerous…

Deep learning builds the foundation for many medical image analysis tasks where neuralnetworks are often designed to have a large receptive field to incorporate long spatialdependencies. Recent work has shown that large receptive fields are…

Image and Video Processing · Electrical Eng. & Systems 2019-07-27 Nick Pawlowski , Ben Glocker

Cognitive decline is highly heterogeneous across individuals, which complicates prognosis, trial design, and treatment planning. We present the Personalized Cognitive Decline Assessment Digital Twin (PCD-DT), a multimodal and…

Artificial Intelligence · Computer Science 2026-05-01 Bulent Soykan , Gulsah Hancerliogullari Koksalmis , Hsin-Hsiung Huang , Laura J. Brattain

A digital twin is a powerful tool that can help monitor and optimize physical assets in real-time. Simply put, it is a virtual representation of a physical asset, enabled through data and simulators, that can be used for a variety of…

Computer Vision and Pattern Recognition · Computer Science 2023-03-01 Elias Mohammed Elfarri , Adil Rasheed , Omer San

Digital twin worlds with realistic interactive dynamics presents a new opportunity to develop generalist embodied agents in scannable environments with complex physical behaviors. To this end, we present GDGen (Generalized Representation…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Yichen Li , Zhiyi Li , Brandon Feng , Dinghuai Zhang , Antonio Torralba

Age prediction based on appearances of different anatomies in medical images has been clinically explored for many decades. In this paper, we used deep learning to predict a persons age on Chest X-Rays. Specifically, we trained a CNN in…

Computer Vision and Pattern Recognition · Computer Science 2019-03-18 Alexandros Karargyris , Satyananda Kashyap , Joy T Wu , Arjun Sharma , Mehdi Moradi , Tanveer Syeda-Mahmood

This paper addresses the modeling and simulation of progressive changes over time, such as human face aging. By treating the age phases as a sequence of image domains, we construct a chain of transformers that map images from one age domain…

Computer Vision and Pattern Recognition · Computer Science 2018-08-08 Ari Heljakka , Arno Solin , Juho Kannala

Recently, significant efforts have been made to create Health Digital Twins (HDTs), digital twins for clinical applications. Heart modeling is one of the fastest-growing fields, which favors the effective application of HDTs. The clinical…

Neurons and Cognition · Quantitative Biology 2024-03-21 Zofia Rudnicka , Klaudia Proniewska , Mark Perkins , Agnieszka Pregowska

Generative Artificial Intelligence (AI) has rapidly advanced the field of computer vision by enabling machines to create and interpret visual data with unprecedented sophistication. This transformation builds upon a foundation of generative…

Computer Vision and Pattern Recognition · Computer Science 2025-04-22 Daochang Liu , Junyu Zhang , Anh-Dung Dinh , Eunbyung Park , Shichao Zhang , Ajmal Mian , Mubarak Shah , Chang Xu

A digital twin can be defined as an adaptive model of a complex physical system. Recent advances in computational pipelines, multiphysics solvers, artificial intelligence, big data cybernetics, data processing and management tools bring the…

Signal Processing · Electrical Eng. & Systems 2019-10-07 Adil Rasheed , Omer San , Trond Kvamsdal

The gradual accumulation of damage and dysregulation during the aging of living organisms can be quantified. Even so, the aging process is complex and has multiple interacting physiological scales -- from the molecular to cellular to whole…

Quantitative Methods · Quantitative Biology 2021-05-06 Spencer Farrell , Garrett Stubbings , Kenneth Rockwood , Arnold Mitnitski , Andrew Rutenberg

How will my face look when I get older? Or, for a more challenging question: How will my brain look when I get older? To answer this question one must devise (and learn from data) a multivariate auto-regressive function which given an image…

Image and Video Processing · Electrical Eng. & Systems 2021-10-01 Tian Xia , Agisilaos Chartsias , Chengjia Wang , Sotirios A. Tsaftaris

The digital transformation of modern cities by integrating advanced information, communication, and computing technologies has marked the epoch of data-driven smart city applications for efficient and sustainable urban management. Despite…

Artificial Intelligence · Computer Science 2024-08-08 Haowen Xu , Femi Omitaomu , Soheil Sabri , Sisi Zlatanova , Xiao Li , Yongze Song