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We propose characteristics-informed neural networks (CINN), a simple and efficient machine learning approach for solving forward and inverse problems involving hyperbolic PDEs. Like physics-informed neural networks (PINN), CINN is a…
Immunohistochemical (IHC) staining serves as a valuable technique for detecting specific antigens or proteins through antibody-mediated visualization. However, the IHC staining process is both time-consuming and costly. To address these…
Prior normalization methods rely on affine transformations to produce arbitrary image style transfers, of which the parameters are computed in a pre-defined way. Such manually-defined nature eventually results in the high-cost and shared…
With the rapid development of digital pathology, virtual staining has become a key technology in multimedia medical information systems, offering new possibilities for the analysis and diagnosis of pathological images. However, existing…
Immunohistochemical (IHC) stains play a vital role in a pathologist's analysis of medical images, providing crucial diagnostic information for various diseases. Virtual staining from hematoxylin and eosin (H&E)-stained whole slide images…
In this paper, we explore the role of Instance Normalization in low-level vision tasks. Specifically, we present a novel block: Half Instance Normalization Block (HIN Block), to boost the performance of image restoration networks. Based on…
Unpaired image-to-image translation is a class of vision problems whose goal is to find the mapping between different image domains using unpaired training data. Cycle-consistency loss is a widely used constraint for such problems. However,…
Nuclei instance segmentation in hematoxylin and eosin (H&E)-stained images plays an important role in automated histological image analysis, with various applications in downstream tasks. While several machine learning and deep learning…
Deep learning has achieved great success in the challenging circuit annotation task by employing Convolutional Neural Networks (CNN) for the segmentation of circuit structures. The deep learning approaches require a large amount of manually…
Due to recent advances in technology, digitized histopathology images are now widely available for both clinical and research purposes. Accordingly, research into computerized image analysis algorithms for digital histopathology images has…
Separating the contributions of individual chromogenic stains in RGB histology whole slide images (WSIs) is essential for stain normalization, quantitative assessment of marker expression, and cell-level readouts in immunohistochemistry…
Neural-networks based image restoration methods tend to use low-resolution image patches for training. Although higher-resolution image patches can provide more global information, state-of-the-art methods cannot utilize them due to their…
Human skin detection in images is a widely studied topic of Computer Vision for which it is commonly accepted that analysis of pixel color or local patches may suffice. This is because skin regions appear to be relatively uniform and many…
Pathology foundation models learn morphological representations through self-supervised pretraining on large-scale whole-slide images, yet they do not explicitly capture the underlying molecular state of the tissue. Spatial transcriptomics…
Normalization layers are essential in a Deep Convolutional Neural Network (DCNN). Various normalization methods have been proposed. The statistics used to normalize the feature maps can be computed at batch, channel, or instance level.…
In this paper, we propose a sinogram inpainting network (SIN) to solve limited-angle CT reconstruction problem, which is a very challenging ill-posed issue and of great interest for several clinical applications. A common approach to the…
Although multi-instance learning (MIL) has succeeded in pathological image classification, it faces the challenge of high inference costs due to processing numerous patches from gigapixel whole slide images (WSIs). To address this, we…
Recently, unsupervised exemplar-based image-to-image translation, conditioned on a given exemplar without the paired data, has accomplished substantial advancements. In order to transfer the information from an exemplar to an input image,…
Three-dimensional (3D) histopathology of unprocessed tissues has the potential to transform disease management by enabling volumetric characterization of tissue microarchitecture and in-vivo assessment. Back-illumination Interference…
Spatial transcriptomics (ST) enables gene expression mapping within anatomical context but remains costly and low-throughput. Hematoxylin and eosin (H\&E) staining offers rich morphology yet lacks molecular resolution. We present…