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Related papers: 3D Graph Contrastive Learning for Molecular Proper…

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This paper focuses on learning representation on the whole graph level in an unsupervised manner. Learning graph-level representation plays an important role in a variety of real-world issues such as molecule property prediction, protein…

Machine Learning · Computer Science 2024-01-08 Ge Wang , Zelin Zang , Jiangbin Zheng , Jun Xia , Stan Z. Li

Self-supervised contrastive learning (CL) has achieved remarkable empirical success, often producing representations that rival supervised pre-training on downstream tasks. Recent theory explains this by showing that the CL loss closely…

Machine Learning · Computer Science 2025-10-13 Achleshwar Luthra , Priyadarsi Mishra , Tomer Galanti

Contrastive self-supervised learning (CSL) is an approach to learn useful representations by solving a pretext task that selects and compares anchor, negative and positive (APN) features from an unlabeled dataset. We present a conceptual…

Computer Vision and Pattern Recognition · Computer Science 2020-09-02 William Falcon , Kyunghyun Cho

Self-supervised learning (SSL) excels at finding general-purpose latent representations from complex data, yet lacks a unifying theoretical framework that explains the diverse existing methods and guides the design of new ones. We cast SSL…

Machine Learning · Computer Science 2026-05-28 Fabian A Mikulasch , Friedemann Zenke

Self-Supervised Learning (SSL) is an increasingly popular ML paradigm that trains models to transform complex inputs into representations without relying on explicit labels. These representations encode similarity structures that enable…

Machine Learning · Computer Science 2022-06-30 Adam Dziedzic , Nikita Dhawan , Muhammad Ahmad Kaleem , Jonas Guan , Nicolas Papernot

Contrastive learning (CL) has recently emerged as an alternative to traditional supervised machine learning solutions by enabling rich representations from unstructured and unlabeled data. However, CL and, more broadly, self-supervised…

Machine Learning · Computer Science 2025-07-10 Roberto Pereira , Fernanda Famá , Asal Rangrazi , Marco Miozzo , Charalampos Kalalas , Paolo Dini

Deep learning-based drug response prediction (DRP) methods can accelerate the drug discovery process and reduce R\&D costs. Although the mainstream methods achieve high accuracy in predicting response regression values, the regression-aware…

Biomolecules · Quantitative Biology 2023-12-19 Kun Li , Wenbin Hu

Accurate molecular property prediction requires integrating complementary information from molecular structure and chemical semantics. In this work, we propose LGM-CL, a local-global multimodal contrastive learning framework that jointly…

Machine Learning · Computer Science 2026-02-02 Xiayu Liu , Zhengyi Lu , Yunhong Liao , Chan Fan , Hou-biao Li

Contrastive learning is among the most successful methods for visual representation learning, and its performance can be further improved by jointly performing clustering on the learned representations. However, existing methods for joint…

Computer Vision and Pattern Recognition · Computer Science 2022-09-16 Shunjie-Fabian Zheng , JaeEun Nam , Emilio Dorigatti , Bernd Bischl , Shekoofeh Azizi , Mina Rezaei

Effective protein representation learning is crucial for predicting protein functions. Traditional methods often pretrain protein language models on large, unlabeled amino acid sequences, followed by finetuning on labeled data. While…

Biomolecules · Quantitative Biology 2024-09-05 Jiangbin Zheng , Stan Z. Li

Artificial intelligence (AI) is anticipated to play a pivotal role in 6G. However, a key challenge in developing AI-powered solutions is the extensive data collection and labeling efforts required to train supervised deep learning models.…

Signal Processing · Electrical Eng. & Systems 2025-09-04 Ogechukwu Kanu , Ashkan Eshaghbeigi , Hatem Abou-Zeid

Deep models trained in supervised mode have achieved remarkable success on a variety of tasks. When labeled samples are limited, self-supervised learning (SSL) is emerging as a new paradigm for making use of large amounts of unlabeled…

Machine Learning · Computer Science 2022-04-26 Yaochen Xie , Zhao Xu , Jingtun Zhang , Zhengyang Wang , Shuiwang Ji

Graph-level representations are critical in various real-world applications, such as predicting the properties of molecules. But in practice, precise graph annotations are generally very expensive and time-consuming. To address this issue,…

Machine Learning · Computer Science 2022-07-26 Shuai Lin , Pan Zhou , Zi-Yuan Hu , Shuojia Wang , Ruihui Zhao , Yefeng Zheng , Liang Lin , Eric Xing , Xiaodan Liang

Foundation models have achieved great success in natural language processing (NLP) and computer vision (CV). Their success largely stems from the ability to integrate multi-domain knowledge in pre-training and transfer it to target domains.…

Computation and Language · Computer Science 2025-07-01 Zihao Zhao , Xinlong Zhai , Jinyu Yang , Chuan Shi

Self-supervised learning (SSL) is a scalable way to learn general visual representations since it learns without labels. However, large-scale unlabeled datasets in the wild often have long-tailed label distributions, where we know little…

Machine Learning · Computer Science 2022-05-24 Hong Liu , Jeff Z. HaoChen , Adrien Gaidon , Tengyu Ma

Generalizable, transferrable, and robust representation learning on graph-structured data remains a challenge for current graph neural networks (GNNs). Unlike what has been developed for convolutional neural networks (CNNs) for image data,…

Machine Learning · Computer Science 2021-04-06 Yuning You , Tianlong Chen , Yongduo Sui , Ting Chen , Zhangyang Wang , Yang Shen

Self-supervised learning (SSL) has emerged as a powerful paradigm for learning representations on graph data without requiring manual labels. However, leading SSL methods like GRACE are fundamentally incompatible with privacy-preserving…

Machine Learning · Computer Science 2025-10-01 Daksh Pandey

Predicting molecular properties with data-driven methods has drawn much attention in recent years. Particularly, Graph Neural Networks (GNNs) have demonstrated remarkable success in various molecular generation and prediction tasks. In…

Quantitative Methods · Quantitative Biology 2021-10-19 Zaixi Zhang , Qi Liu , Hao Wang , Chengqiang Lu , Chee-Kong Lee

Recent contrastive learning methods have shown to be effective in various tasks, learning generalizable representations invariant to data augmentation thereby leading to state of the art performances. Regarding the multifaceted nature of…

Machine Learning · Computer Science 2022-05-27 MinGyu Choi , Wonseok Shin , Yijingxiu Lu , Sun Kim

Self-Supervised Learning (SSL) enables us to pre-train foundation models without costly labeled data. Among SSL methods, Contrastive Learning (CL) methods are better at obtaining accurate semantic representations in noise interference.…

Image and Video Processing · Electrical Eng. & Systems 2026-02-06 Hengtong Shen , Haiyan Gu , Haitao Li , Yi Yang , Agen Qiu