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Parametric nonlinear mixed effects models (NLMEs) are now widely used in biometrical studies, especially in pharmacokinetics research and HIV dynamics models, due to, among other aspects, the computational advances achieved during the last…

Methodology · Statistics 2012-02-03 Ana Arribas-Gil , Karine Bertin , Cristian Meza , Vincent Rivoirard

In this paper we introduce a new methodology to determine an optimal coefficient of penalized functional regression. We assume the dependent, independent variables and the regression coefficients are functions of time and error dynamics…

Methodology · Statistics 2021-07-07 Paramahansa Pramanik , Alan M. Polansky

Sparse regularized regression methods are now widely used in genome-wide association studies (GWAS) to address the multiple testing burden that limits discovery of potentially important predictors. Linear mixed models (LMMs) have become an…

Methodology · Statistics 2022-06-27 Julien St-Pierre , Karim Oualkacha , Sahir Rai Bhatnagar

Using a multiplicative reparametrization, I show that a subclass of $L_q$ penalties with $q\leq 1$ can be expressed as sums of $L_2$ penalties. It follows that the lasso and other norm-penalized regression estimates may be obtained using a…

Computation · Statistics 2017-05-22 Peter D. Hoff

Similar to variable selection in the linear regression model, selecting significant components in the popular additive regression model is of great interest. However, such components are unknown smooth functions of independent variables,…

Methodology · Statistics 2011-01-04 Xia Cui , Heng Peng , Songqiao Wen , Lixing Zhu

We consider the problem of sparse estimation via a lasso-type penalized likelihood procedure in a factor analysis model. Typically, the model estimation is done under the assumption that the common factors are orthogonal (uncorrelated).…

Methodology · Statistics 2013-02-25 Kei Hirose , Michio Yamamoto

This article describes a full Bayesian treatment for simultaneous fixed-effect selection and parameter estimation in high-dimensional generalized linear mixed models. The approach consists of using a Bayesian adaptive Lasso penalty for…

Methodology · Statistics 2016-08-31 Dao Thanh Tung , Minh-Ngoc Tran , Tran Manh Cuong

We study maximum likelihood estimation for spatial generalized linear mixed models with Gaussian process approximations using a stochastic Newton-Raphson algorithm. We consider two Gaussian Process approximations in this context: spectral…

Methodology · Statistics 2026-05-19 Samuel I. Watson , Yixin Wang , Emanuele Giorgi

Gaussian processes (GPs) are popular as nonlinear regression models for expensive computer simulations, yet GP performance relies heavily on estimation of unknown covariance parameters. Maximum likelihood estimation (MLE) is common, but it…

Methodology · Statistics 2025-11-25 Ayumi Mutoh , Annie S. Booth , Jonathan W. Stallrich

Current status data are commonly encountered in medical and epidemiological studies in which the failure time for study units is the outcome variable of interest. Data of this form are characterized by the fact that the failure time is not…

Methodology · Statistics 2019-04-25 Yan Liu , Minggen Lu , Christopher S. McMahan

The tuning parameter selection strategy for penalized estimation is crucial to identify a model that is both interpretable and predictive. However, popular strategies (e.g., minimizing average squared prediction error via cross-validation)…

Methodology · Statistics 2022-11-10 Julia Holter , Jonathan Stallrich

We consider efficient estimation of flexible transformation models with interval-censored data. To reduce the dimension of semi-parametric models, the unknown monotone transformation function is approximated via monotone splines. A…

Methodology · Statistics 2019-12-30 Minggen Lu , Yan Liu , Chin-Shang Li , Jianguo Sun

The function-on-function regression model is fundamental for analyzing relationships between functional covariates and responses. However, most existing function-on-function regression methodologies assume independence between observations,…

Methodology · Statistics 2025-12-02 Ufuk Beyaztas , Han Lin Shang , Gizel Bakicierler Sezer

We study functional regression with random subgaussian design and real-valued response. The focus is on the problems in which the regression function can be well approximated by a functional linear model with the slope function being…

Statistics Theory · Mathematics 2014-09-16 Vladimir Koltchinskii , Stanislav Minsker

We propose a deep neural network (DNN) based least distance (LD) estimator (DNN-LD) for a multivariate regression problem, addressing the limitations of the conventional methods. Due to the flexibility of a DNN structure, both linear and…

Methodology · Statistics 2024-01-09 Jungmin Shin , Seung Jun Shin , Sungwan Bang

Propensity score (PS) based estimators are increasingly used for causal inference in observational studies. However, model selection for PS estimation in high-dimensional data has received little attention. In these settings, PS models have…

We propose a new and computationally efficient algorithm for maximizing the observed log-likelihood for a multivariate normal data matrix with missing values. We show that our procedure based on iteratively regressing the missing on the…

Methodology · Statistics 2012-11-21 Nicolas Städler , Daniel J. Stekhoven , Peter Bühlmann

Mixtures-of-Experts models and their maximum likelihood estimation (MLE) via the EM algorithm have been thoroughly studied in the statistics and machine learning literature. They are subject of a growing investigation in the context of…

Machine Learning · Statistics 2019-09-13 Faïcel Chamroukhi , Florian Lecocq , Hien D. Nguyen

We introduce the Meta Highly-Adaptive-Lasso Minimum Loss Estimator (M-HAL-MLE), a novel ensemble approach for estimating functional parameters of realistically modeled data distribution from independent and identically distributed…

Methodology · Statistics 2025-07-28 Zeyi Wang , Wenxin Zhang , Brian S Caffo , Martin Lindquist , Mark van der Laan

The ordinary least squares estimate in linear regression is sensitive to the influence of errors with large variance, which reduces its robustness, especially when dealing with heavy-tailed errors or outliers frequently encountered in…

Methodology · Statistics 2025-05-01 Mengjiao Shi , Yunhai Xiao