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Computational methods in drug repositioning can help to conserve resources. In particular, methods based on biological networks are showing promise. Considering only the network topology and knowledge on drug target genes is not sufficient…

Molecular Networks · Quantitative Biology 2025-04-02 Atte Aalto , La Mi , Diego A. Blanco-Mora , Jorge Goncalves

Nonnegative Matrix Factorization (NMF) aims to factorize a matrix into two optimized nonnegative matrices appropriate for the intended applications. The method has been widely used for unsupervised learning tasks, including recommender…

Machine Learning · Statistics 2015-07-14 Junyu Xuan , Jie Lu , Guangquan Zhang , Richard Yi Da Xu , Xiangfeng Luo

Classical computing has borne witness to the development of machine learning. The integration of quantum technology into this mix will lead to unimaginable benefits and be regarded as a giant leap forward in mankind's ability to compute.…

Quantum Physics · Physics 2023-11-03 Hinako Asaoka , Kazue Kudo

Matrix factorization-based recommender system is in effect an angle preserving dimensionality reduction technique. Since the frequency of items follows power-law distribution, most vectors in the original dimension of user feature vectors…

Information Retrieval · Computer Science 2023-01-11 Hao Wang

Bayesian model-based clustering is a widely applied procedure for discovering groups of related observations in a dataset. These approaches use Bayesian mixture models, estimated with MCMC, which provide posterior samples of the model…

Methodology · Statistics 2018-09-24 Ketong Wang , Michael D. Porter

Missing link prediction is a method for network analysis, with applications in recommender systems, biology, social sciences, cybersecurity, information retrieval, and Artificial Intelligence (AI) reasoning in Knowledge Graphs. Missing link…

Machine Learning · Computer Science 2025-03-07 Ryan Barron , Maksim E. Eren , Duc P. Truong , Cynthia Matuszek , James Wendelberger , Mary F. Dorn , Boian Alexandrov

Background: In silico drug-target interaction (DTI) prediction plays an integral role in drug repositioning: the discovery of new uses for existing drugs. One popular method of drug repositioning is network-based DTI prediction, which uses…

Artificial Intelligence · Computer Science 2017-11-02 Yiding Lu , Yufan Guo , Anna Korhonen

There has been a recent critical need to study fairness and bias in machine learning (ML) algorithms. Since there is clearly no one-size-fits-all solution to fairness, ML methods should be developed alongside bias mitigation strategies that…

Machine Learning · Computer Science 2026-03-06 Lara Kassab , Erin George , Deanna Needell , Haowen Geng , Nika Jafar Nia , Aoxi Li

Matrix factorization is an important mathematical problem encountered in the context of dictionary learning, recommendation systems and machine learning. We introduce a new `decimation' scheme that maps it to neural network models of…

Disordered Systems and Neural Networks · Physics 2023-07-12 Francesco Camilli , Marc Mézard

Nonnegative matrix factorization (NMF) was popularized as a tool for data mining by Lee and Seung in 1999. NMF attempts to approximate a matrix with nonnegative entries by a product of two low-rank matrices, also with nonnegative entries.…

Information Retrieval · Computer Science 2008-05-02 Michael Biggs , Ali Ghodsi , Stephen Vavasis

While deep-learning based recommender systems utilizing collaborative filtering have been commonly used for recommendation in other domains, their application in the medical domain have been limited. In addition to modeling user-item…

Information Retrieval · Computer Science 2023-09-19 Aashish Cheruvu

Non-negative matrix factorisation (NMF) is a widely used tool for unsupervised learning and feature extraction, with applications ranging from genomics to text analysis and signal processing. Standard formulations of NMF are typically…

Machine Learning · Computer Science 2026-03-11 Elisabeth Sommer James , Asger Hobolth , Marta Pelizzola

Matrix Factorization (MF) has found numerous applications in Machine Learning and Data Mining, including collaborative filtering recommendation systems, dimensionality reduction, data visualization, and community detection. Motivated by the…

Machine Learning · Computer Science 2023-09-26 Ioannis Kordonis , Emmanouil Theodosis , George Retsinas , Petros Maragos

Despite considerable progress in genome- and proteome-based high-throughput screening methods and rational drug design, the number of successful single target drugs did not increase appreciably during the past decade. Network models suggest…

Molecular Networks · Quantitative Biology 2007-05-23 Peter Csermely , Vilmos Agoston , Sandor Pongor

Boolean matrix factorization (BMF) is a popular and powerful technique for inferring knowledge from data. The mining result is the Boolean product of two matrices, approximating the input dataset. The Boolean product is a disjunction of…

Machine Learning · Computer Science 2019-07-02 Sibylle Hess , Nico Piatkowski , Katharina Morik

Overdose related to prescription opioids have reached an epidemic level in the US, creating an unprecedented national crisis. This has been exacerbated partly due to the lack of tools for physicians to help predict the risk of whether a…

Recently, Factorization Machines (FM) has become more and more popular for recommendation systems, due to its effectiveness in finding informative interactions between features. Usually, the weights for the interactions is learnt as a low…

Machine Learning · Computer Science 2018-04-18 Longfei Li , Peilin Zhao , Jun Zhou , Xiaolong Li

Symmetric nonnegative matrix factorization (NMF), a special but important class of the general NMF, is demonstrated to be useful for data analysis and in particular for various clustering tasks. Unfortunately, designing fast algorithms for…

Machine Learning · Computer Science 2018-11-15 Zhihui Zhu , Xiao Li , Kai Liu , Qiuwei Li

Matrix factorization is a widely adopted recommender system technique that fits scalar rating values by dot products of user feature vectors and item feature vectors. However, the formulation of matrix factorization as a scalar fitting…

Information Retrieval · Computer Science 2021-12-07 Hao Wang

Review-based recommender systems have gained noticeable ground in recent years. In addition to the rating scores, those systems are enriched with textual evaluations of items by the users. Neural language processing models, on the other…

Information Retrieval · Computer Science 2018-01-11 Georgios Alexandridis , Georgios Siolas , Andreas Stafylopatis