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In pharmaceutical R&D, predicting the efficacy of a pharmaceutical in treating a particular disease prior to clinical testing or any real-world use has been challenging. In this paper, we propose a flexible and modular machine…

Machine Learning · Computer Science 2025-09-10 Adrien Couetoux , Thomas Devenyns , Lise Diagne , David Champagne , Pierre-Yves Mousset , Chris Anagnostopoulos

Social recommender systems exploit users' social relationships to improve the recommendation accuracy. Intuitively, a user tends to trust different subsets of her social friends, regarding with different scenarios. Therefore, the main…

Information Retrieval · Computer Science 2016-03-16 Yong Liu , Peilin Zhao , Xin Liu , Min Wu , Xiao-Li Li

Recommender systems are a kind of data filtering that guides the user to interesting and valuable resources within an extensive dataset. by providing suggestions of products that are expected to match their preferences. However, due to data…

Information Retrieval · Computer Science 2024-06-18 Sajida Mhammedi , Hakim El Massari , Noreddine Gherabi , Amnai Mohamed

Non-negative Matrix Factorisation (NMF) has been extensively used in machine learning and data analytics applications. Most existing variations of NMF only consider how each row/column vector of factorised matrices should be shaped, and…

Machine Learning · Computer Science 2019-07-09 Shuai Jiang , Kan Li , Richard Yida Xu

Non-negative Matrix Factorization (NMF) is an intensively used technique for obtaining parts-based, lower dimensional and non-negative representation. Researchers in biology, medicine, pharmacy and other fields often prefer NMF over other…

Machine Learning · Computer Science 2025-02-04 Matej Mihelčić , Pauli Miettinen

Non-Negative Matrix Factorization (NMF) is an unsupervised learning method offering low-rank representations across various domains such as audio processing, biomedical signal analysis, and image recognition. The incorporation of…

Machine Learning · Computer Science 2025-10-09 Yasaman Torabi , Shahram Shirani , James P. Reilly

Development of new medications is a very lengthy and costly process. Finding novel indications for existing drugs, or drug repositioning, can serve as a useful strategy to shorten the development cycle. In this study, we present an approach…

Genomics · Quantitative Biology 2017-12-13 Kai Zhao , Hon-Cheong So

When recommending personalized top-$k$ items to users, how can we recommend the items diversely to them while satisfying their needs? Aggregately diversified recommender systems aim to recommend a variety of items across whole users without…

Information Retrieval · Computer Science 2022-11-03 Jongjin Kim , Hyunsik Jeon , Jaeri Lee , U Kang

Drug-drug interactions are preventable causes of medical injuries and often result in doctor and emergency room visits. Computational techniques can be used to predict potential drug-drug interactions. We approach the drug-drug interaction…

Machine Learning · Computer Science 2019-08-06 Guy Shtar , Lior Rokach , Bracha Shapira

Nonnegative matrix factorization (NMF) is widely used for clustering with strong interpretability. Among general NMF problems, symmetric NMF is a special one that plays an important role in graph clustering where each element measures the…

Machine Learning · Computer Science 2023-11-07 Mengyuan Zhang , Kai Liu

Non-negative matrix factorization (NMF) is a prob- lem with many applications, ranging from facial recognition to document clustering. However, due to the variety of algorithms that solve NMF, the randomness involved in these algorithms,…

Numerical Analysis · Mathematics 2018-12-17 Connor Sell , Jeremy Kepner

Nonnegative Matrix Factorization (NMF), first proposed in 1994 for data analysis, has received successively much attention in a great variety of contexts such as data mining, text clustering, computer vision, bioinformatics, etc. In this…

Numerical Analysis · Mathematics 2019-03-05 Paola Favati , Grazia Lotti , Ornella Menchi , Francesco Romani

Recommender system recommends interesting items to users based on users' past information history. Researchers have been paying attention to improvement of algorithmic performance such as MAE and precision@K. Major techniques such as matrix…

Information Retrieval · Computer Science 2021-08-09 Hao Wang

Nonnegative matrix factorization (NMF) is a powerful class of feature extraction techniques that has been successfully applied in many fields, namely in signal and image processing. Current NMF techniques have been limited to a…

Machine Learning · Statistics 2015-01-26 Paul Honeine , Fei Zhu

The extraction of biomedical data has significant academic and practical value in contemporary biomedical sciences. In recent years, drug repositioning, a cost-effective strategy for drug development by discovering new indications for…

Machine Learning · Computer Science 2025-01-20 Enqiang Zhu , Xiang Li , Chanjuan Liu , Nikhil R. Pal

A comprehensive pharmaceutical recommendation system was designed based on the patients and drugs features extracted from Drugs.com and Druglib.com. First, data from these databases were combined, and a dataset of patients and drug…

Motivation: Adverse reactions from drug combinations are increasingly common, making their accurate prediction a crucial challenge in modern medicine. Laboratory-based identification of these reactions is insufficient due to the…

Machine Learning · Computer Science 2024-12-10 Oliver Lloyd , Yi Liu , Tom R. Gaunt

Recommender systems are emerging technologies that nowadays can be found in many applications such as Amazon, Netflix, and so on. These systems help users to find relevant information, recommendations, and their preferred items. Slightly…

Machine Learning · Computer Science 2013-08-05 Nima Mirbakhsh , Charles X. Ling

Recommender system has been more and more popular and widely used in many applications recently. The increasing information available, not only in quantities but also in types, leads to a big challenge for recommender system that how to…

Artificial Intelligence · Computer Science 2011-12-30 Tianqi Chen , Zhao Zheng , Qiuxia Lu , Weinan Zhang , Yong Yu

Beyond accuracy, quality measures are gaining importance in modern recommender systems, with reliability being one of the most important indicators in the context of collaborative filtering. This paper proposes Bernoulli Matrix…

Machine Learning · Computer Science 2022-03-07 Fernando Ortega , Raúl Lara-Cabrera , Ángel González-Prieto , Jesús Bobadilla