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In this paper we propose a neurogeometrical model of the behaviour of cells of the arm area of the primary motor cortex (M1). We mathematically express the hypercolumnar organization of M1 discovered by Georgopoulos, as a fiber bundle, as…

Neurons and Cognition · Quantitative Biology 2023-06-16 Caterina Mazzetti , Alessandro Sarti , Giovanna Citti

We develop a neurogeometric model for the arm area of motor cortex, which encodes complex motor primitives, ranging from simple movement features like movement direction, to short hand trajectories, termed fragments, and ultimately to more…

Neurons and Cognition · Quantitative Biology 2026-02-13 Caterina Mazzetti , Jawad Ali , Alessandro Sarti , Giovanna Citti

Motor cortex (M1) is a crucial brain area for controlling voluntary movements, such as reaching and grasping for a cup of coffee. M1 is organized in a somatotopic manner, such that M1 output driving movement to different parts of the body…

Neurons and Cognition · Quantitative Biology 2025-08-07 Nicholas Chehade

In this paper, we propose a model of arm reaching movements expressed in terms of geodesics in a sub-Riemannian space. We will choose a set of kinematic variables to which motor cortical cells are selective with the purpose of modelling the…

Optimization and Control · Mathematics 2023-01-18 Caterina Mazzetti , Alessandro Sarti , Giovanna Citti

High-dimensional neural activity often reside in a low-dimensional subspace, referred to as neural manifolds. Grid cells in the medial entorhinal cortex provide a periodic spatial code that are organized near a toroidal manifold,…

Neurons and Cognition · Quantitative Biology 2025-10-22 Yuxing Jared Yao , Iris H. R. Yoon

In present paper we discuss several approaches to reconstructing the topology of the physical space from neural activity data of CA1 fields in mice hippocampus, in particular, having Cognitome theory of brain function in mind. In our…

Neurons and Cognition · Quantitative Biology 2022-12-07 Konstantin Sorokin , Anton Ayzenberg , Konstantin Anokhin , Vladimir Sotskov , Maxim Beketov , Andrey Zaitsew , Robert Drynkin

The initial sections of the paper give a concise presentation, specially designed for a mathematically oriented audience, of some of the most basic facts on the functional architecture of early vision. Such information is usually scattered…

Neurons and Cognition · Quantitative Biology 2024-10-29 Dmitri V. Alekseevsky , Andrea Spiro

The proposed analysis of the currently available experimental results concerning the neural cell activity in the brain area known as hippocampus suggests a particular mechanism of spatial information and memory processing. Below it is…

Other Quantitative Biology · Quantitative Biology 2007-05-23 Yu. Dabaghian , A. G. Cohn , L. Frank

In the mammalian brain, many neuronal ensembles are involved in representing spatial structure of the environment. In particular, there exist cells that encode the animal's location and cells that encode head direction. A number of studies…

Neurons and Cognition · Quantitative Biology 2021-08-10 Y. Dabaghian

This paper investigates the online estimation of neural activity within the primary visual cortex (V1) in the framework of observability theory. We focus on a low-dimensional neural fields modeling hypercolumnar activity to describe…

Optimization and Control · Mathematics 2024-03-05 Adel Malik Annabi , Dario Prandi , Jean-Baptiste Pomet , Ludovic Sacchelli

Codifying memories is one of the fundamental problems of modern Neuroscience. The functional mechanisms behind this phenomenon remain largely unknown. Experimental evidence suggests that some of the memory functions are performed by…

Neurons and Cognition · Quantitative Biology 2022-05-17 Ivan Y. Tyukin , Alexander N. Gorban , Carlos Calvo , Julia Makarova , Valeri A. Makarov

The visual information in V1 is processed by an array of modules called orientation preference columns. In some species including humans, orientation columns are radially arranged around singular points like the spokes of a wheel, that are…

Mathematical Physics · Physics 2010-07-09 Davide Barbieri , Giovanna Citti , Gonzalo Sanguinetti , Alessandro Sarti

Primary visual cortex (V1) is the first stage of cortical image processing, and a major effort in systems neuroscience is devoted to understanding how it encodes information about visual stimuli. Within V1, many neurons respond selectively…

Neurons and Cognition · Quantitative Biology 2017-06-21 William F. Kindel , Elijah D. Christensen , Joel Zylberberg

At the turn of the 20th century, Henri Poincar{\'e} explained that geometry is a convention and that the properties of space and time are the properties of our measuring instruments. Intriguingly, numerous contemporary authors argue that…

Neurons and Cognition · Quantitative Biology 2024-05-17 Laurent Goffart

We present a fiber-distributed model of the reinforcing collagen of the human cornea. The model describes the basic connections between the components of the tissue by defining an elementary block (cell) and upscaling it to the physical…

Biological Physics · Physics 2023-06-28 Maria Laura De Bellis , Marcello Vasta , Alessio Gizzi , Anna Pandolfi

We propose a differential geometric model of hypercolumns in the primary visual cortex V1 that combines features of the symplectic model of the primary visual cortex by A. Sarti, G. Citti and J. Petitot and of the spherical model of…

Neurons and Cognition · Quantitative Biology 2024-10-29 D. V. Alekseevsky , A. Spiro

Hippocampal neurons track positions of self, others, and gaze direction. However, it is unclear how their respective neural codes differ enough to avoid confusion while allowing for abstraction. We recorded from populations of hippocampal…

Grid cells in the entorhinal cortex encode the position of an animal in its environment using spatially periodic tuning curves of varying periodicity. Recent experiments established that these cells are functionally organized in discrete…

Neurons and Cognition · Quantitative Biology 2016-01-13 Noga Weiss Mosheiff , Haggai Agmon , Avraham Moriel , Yoram Burak

Grid cells in the entorhinal cortex, together with head direction, place, speed and border cells, are major contributors to the organization of spatial representations in the brain. In this work we introduce a novel theoretical and…

Neurons and Cognition · Quantitative Biology 2019-07-25 Fabio Anselmi , Micah M. Murray , Benedetta Franceschiello

We introduce a novel data-driven approach to discover and decode features in the neural code coming from large population neural recordings with minimal assumptions, using cohomological feature extraction. We apply our approach to neural…

Neurons and Cognition · Quantitative Biology 2018-09-11 Erik Rybakken , Nils Baas , Benjamin Dunn
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