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DNA-based data storage systems face practical challenges due to the high cost of DNA synthesis. A strategy to address the problem entails encoding data via topological modifications of the DNA sugar-phosphate backbone. The DNA Punchcards…

Emerging Technologies · Computer Science 2025-05-07 Jin Sima , Chao Pan , S. Kasra Tabatabaei , Alvaro G. Hernandez , Charles M. Schroeder , Olgica Milenkovic

Motivation: Next-generation sequencing tools have enabled producing of huge amount of genomic information at low cost. Unfortunately, presence of sequencing errors in such data affects quality of downstream analyzes. Accuracy of them can be…

Genomics · Quantitative Biology 2017-03-03 Maciej Dlugosz , Sebastian Deorowicz

String edit distances have been used for decades in applications ranging from spelling correction and web search suggestions to DNA analysis. Most string edit distances are variations of the Levenshtein distance and consider only…

Genomics · Quantitative Biology 2022-05-12 Taylor Petty , Jan Hannig , Tunde I Huszar , Hari Iyer

In a digital communication system, information is sent from one place to another over a noisy communication channel using binary symbols (bits). Original information is encoded by adding redundant bits, which are then used by low--density…

Information Theory · Computer Science 2017-09-29 Banu Kabakulak , Z. Caner Taşkın , Ali Emre Pusane

For $q$-ary $n$-sequences, we develop the concept of similarity functions that can be used (for $q=4$) to model a thermodynamic similarity on DNA sequences. A similarity function is identified by the length of a longest common subsequence…

Information Theory · Computer Science 2014-01-30 A. Dyachkov

Codes correcting bursts of deletions and localized deletions have garnered significant research interest in recent years. One of the primary objectives is to construct codes with minimal redundancy. Currently, the best known constructions…

Information Theory · Computer Science 2025-07-08 Zuo Ye , Yubo Sun , Gennian Ge

The prevalent technique for DNA sequencing consists of two main steps: shotgun sequencing, where many randomly located fragments, called reads, are extracted from the overall sequence, followed by an assembly algorithm that aims to…

Genomics · Quantitative Biology 2016-01-28 Shirshendu Ganguly , Elchanan Mossel , Miklos Z. Racz

The problem of correcting deletions has received significant attention, partly because of the prevalence of these errors in DNA data storage. In this paper, we study the problem of correcting a consecutive burst of at most $t$ deletions in…

Information Theory · Computer Science 2022-10-24 Shuche Wang , Yuanyuan Tang , Jin Sima , Ryan Gabrys , Farzad Farnoud

Motivated by applications to DNA storage, we study reconstruction and list-reconstruction schemes for integer vectors that suffer from limited-magnitude errors. We characterize the asymptotic size of the intersection of error balls in…

Information Theory · Computer Science 2021-08-24 Hengjia Wei , Moshe Schwartz

DNA storage has emerged as an important area of research. The reliability of DNA storage system depends on designing the DNA strings (called DNA codes) that are sufficiently dissimilar. In this work, we introduce DNA codes that satisfy a…

Information Theory · Computer Science 2022-11-28 Krishna Gopal Benerjee , Sourav Deb , Manish K Gupta

Recent developments have shown the existence of quantum low-density parity check (qLDPC) codes with constant rate and linear distance. A natural question concerns the efficient decodability of these codes. In this paper, we present a linear…

Quantum Physics · Physics 2022-06-15 Shouzhen Gu , Christopher A. Pattison , Eugene Tang

In order to provide high data reliability, distributed storage systems disperse data with redundancy to multiple storage nodes. Regenerating codes is a new class of erasure codes to introduce redundancy for the purpose of improving the data…

Information Theory · Computer Science 2015-03-18 Kenneth W. Shum , Yuchong Hu

Owing to its immense storage density and durability, DNA has emerged as a promising storage medium. However, due to technological constraints, data can only be written onto many short DNA molecules called data blocks that are stored in an…

Information Theory · Computer Science 2024-03-26 Shubhransh Singhvi , Charchit Gupta , Avital Boruchovsky , Yuval Goldberg , Han Mao Kiah , Eitan Yaakobi

Synchronization errors, such as insertions and deletions, present a fundamental challenge in DNA-based data storage systems, arising from both synthesis and sequencing noise. These channels are often modeled as…

Information Theory · Computer Science 2025-06-23 Ziv Aharoni , Henry D. Pfister

Quantum error correction is expected to be essential in large-scale quantum technologies. However, the substantial overhead of qubits it requires is thought to greatly limit its utility in smaller, near-term devices. Here we introduce a new…

Quantum Physics · Physics 2020-01-20 David Layden , Mo Chen , Paola Cappellaro

Error correction is a significant step in postprocessing of continuous-variable quantum key distribution system, which is used to make two distant legitimate parties share identical corrected keys. We propose an experiment demonstration of…

Quantum Physics · Physics 2018-07-17 Xiangyu Wang , Yi-Chen Zhang , Song Yu , Hong Guo

The biochemical processes underlying DNA data storage, including synthesis, amplification, and sequencing, are inherently noisy. Consequently, base-level insertion, deletion, and substitution (IDS) errors, as well as sequence-level…

Information Theory · Computer Science 2026-03-17 Ramy Khabbaz , Jérémy Mateos , Marc Antonini , Serge Kas Hanna

Based on the extended binary image of non-binary LDPC codes, we propose a method for generating extra redundant bits, such as to decreases the coding rate of a mother code. The proposed method allows for using the same decoder, regardless…

Information Theory · Computer Science 2011-03-15 Lam Pham Sy , Valentin Savin , David Declercq

We consider the problem of efficient construction of q-ary 2-deletion correcting codes with low redundancy. We show that our construction requires less redundancy than any existing efficiently encodable q-ary 2-deletion correcting codes.…

Information Theory · Computer Science 2023-06-12 Shu Liu , Ivan Tjuawinata , Chaoping Xing

The DNA storage channel is considered, in which a codeword is comprised of $M$ unordered DNA molecules. At reading time, $N$ molecules are sampled with replacement, and then each molecule is sequenced. A coded-index concatenated-coding…

Information Theory · Computer Science 2022-05-23 Nir Weinberger