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Real-time monitoring of dynamic biological processes in the body is critical to understanding disease progression and treatment response. This data, for instance, can help address the lower than 50% response rates to cancer immunotherapy.…

Analyzing the cardiovascular system condition via Electrocardiography (ECG) is a common and highly effective approach, and it has been practiced and perfected over many decades. ECG sensing is non-invasive and relatively easy to acquire,…

There has been a consistent growth in research involving imaging of microvasculature over the past few decades. By 2008, publications mentioning the microcirculation had grown more than 2000 per annum. Many techniques have been demonstrated…

Medical Physics · Physics 2019-07-04 Cerine Lal , Martin J Leahy

Micro and nanoscale particles are crucial in various fields, from biomedical imaging to environmental processes. While conventional spectroscopy and microscopy methods for characterizing these particles often involve bulky equipment and…

Biological Physics · Physics 2024-11-26 Jie Liao , Maxwell Adolphson , Hangyue Li , Dipayon Kumar Sikder , Chenyang Lu , Lan Yang

The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware…

Remote photoplethysmography (rPPG) enables contactless measurement of heart rate and other vital signs by analyzing subtle color variations in facial skin induced by cardiac pulsation. Current rPPG methods are mainly based on either…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Junzhe Cao , Bo Zhao , Zhiyi Niu , Dan Guo , Yue Sun , Haochen Liang , Yong Xu , Zitong YU

A technique to measure microscopic rotational motion is presented. When a small fluorescent polystyrene microsphere is attached to a larger polystyrene microsphere, the larger sphere acts as a lens for the smaller microsphere and provides…

Soft Condensed Matter · Physics 2009-10-31 James P. Brody , Stephen R. Quake

Accompanying rapid industrialization, humans are suffering from serious air pollution problems. The demand for air quality prediction is becoming more and more important to the government's policy-making and people's daily life. In this…

Machine Learning · Computer Science 2022-12-09 Kan Huang , Kai Zhang , Ming Liu

A deeper understanding of the influence of common cardiovascular diseases like stenosis, aneurysm or atherosclerosis on the circulatory mechanism is required, to establish new methods for early diagnosis. Different types of simulators were…

Optical flow is a method aimed at predicting the movement velocity of any pixel in the image and is used in medicine and biology to estimate flow of particles in organs or organelles. However, a precise optical flow measurement requires…

Image and Video Processing · Electrical Eng. & Systems 2021-02-16 Adrian Shajkofci , Michael Liebling

Optical and acoustical trapping has been established as a tool for holding and moving microscopic particles suspended in a liquid in a contact-free and non-invasive manner. Opposed to standard microscopic imaging where the probe is fixated,…

Numerical Analysis · Mathematics 2025-10-27 Peter Elbau , Monika Ritsch-Marte , Otmar Scherzer , Denise Schmutz

Voltage-sensitive fluorescence imaging is widely used to image action potential waves in the heart. However, while the electrical waves trigger mechanical contraction, imaging needs to be performed with pharmacologically…

Medical Physics · Physics 2026-03-12 Shrey Chowdhary , Jan Lebert , Shai Dickman , Charles Gordon , Jan Christoph

Minimally invasive interventions performed inside brain vessels with the synergistic use of microcatheters pushed over guidewires have revolutionized the way aneurysms, stroke, arteriovenous malformations, brain tumors and other…

3D motion estimation from cine cardiac magnetic resonance (CMR) images is important for the assessment of cardiac function and the diagnosis of cardiovascular diseases. Current state-of-the art methods focus on estimating dense…

Image and Video Processing · Electrical Eng. & Systems 2023-09-26 Qingjie Meng , Wenjia Bai , Declan P O'Regan , and Daniel Rueckert

Flow cytometry is a technique that measures multiple fluorescence and light scatter-associated parameters from individual cells as they flow a single file through an excitation light source. These cells are labeled with antibodies to detect…

Cerebral autoregulation (CA) is a fundamental mechanism that modulates cerebrovascular resistance, primarily by regulating the diameter of small cerebral vessels to maintain stable cerebral blood flow (CBF) in response to fluctuations in…

Medical Physics · Physics 2025-09-15 Qi Zhang , Meng-di Yang , Xuan-hao Xu , Xiu-li Xu , Shuai Tian , Li-ling Hao

Approximately 10\% of newborns require assistance to initiate breathing at birth, and around 5\% need ventilation support. Fetal heart rate (FHR) monitoring plays a crucial role in assessing fetal well-being during prenatal care, enabling…

Machine Learning · Computer Science 2025-09-26 Kjersti Engan , Neel Kanwal , Anita Yeconia , Ladislaus Blacy , Yuda Munyaw , Estomih Mduma , Hege Ersdal

In vivo fluorescence imaging in the second near-infrared window (1.0-1.7 microns) can afford deep tissue penetration and high spatial resolution, owing to the reduced scattering of long-wavelength photons. Here, we synthesize a series of…

The nature of blood as a suspension of red blood cells makes computational hemodynamics a demanding task. Our coarse-grained blood model, which builds on a lattice Boltzmann method for soft particle suspensions, enables the study of the…

Soft Condensed Matter · Physics 2011-09-16 Florian Janoschek , Francesca Mancini , Jens Harting , Federico Toschi

Elasticity is a fundamental cellular property that is related to the anatomy, functionality and pathological state of cells and tissues. However, current techniques based on cell deformation, atomic force microscopy or Brillouin scattering…