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Synthesis planning and reaction outcome prediction are two fundamental problems in computer-aided organic chemistry for which a variety of data-driven approaches have emerged. Natural language approaches that model each problem as a…

Machine Learning · Computer Science 2021-10-20 Zhengkai Tu , Connor W. Coley

Systematic development of accurate density functionals has been a decades-long challenge for scientists. Despite the emerging application of machine learning (ML) in approximating functionals, the resulting ML functionals usually contain…

Neural and Evolutionary Computing · Computer Science 2022-09-20 He Ma , Arunachalam Narayanaswamy , Patrick Riley , Li Li

The discovery of novel materials and functional molecules can help to solve some of society's most urgent challenges, ranging from efficient energy harvesting and storage to uncovering novel pharmaceutical drug candidates. Traditionally…

Machine Learning · Computer Science 2020-11-06 Mario Krenn , Florian Häse , AkshatKumar Nigam , Pascal Friederich , Alán Aspuru-Guzik

Flowcharts are typically presented as images, driving the trend of using vision-language models (VLMs) for end-to-end flowchart understanding. However, two key challenges arise: (i) Limited controllability--users have minimal influence over…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Junyi Ye , Ankan Dash , Wenpeng Yin , Guiling Wang

Open vocabulary models (e.g. CLIP) have shown strong performance on zero-shot classification through their ability generate embeddings for each class based on their (natural language) names. Prior work has focused on improving the accuracy…

Computer Vision and Pattern Recognition · Computer Science 2023-06-01 Zachary Novack , Julian McAuley , Zachary C. Lipton , Saurabh Garg

We introduce Functional Group-Aware Representations for Small Molecules (FARM), a novel foundation model designed to bridge the gap between SMILES, natural language, and molecular graphs. The key idea behind FARM is the incorporation of…

Machine Learning · Computer Science 2026-04-29 Thao Nguyen , Kuan-Hao Huang , Ge Liu , Martin D. Burke , Ying Diao , Heng Ji

Effective representation of molecules is a crucial factor affecting the performance of artificial intelligence models. This study introduces a flexible, fragment-based, multiscale molecular representation framework called t-SMILES…

Machine Learning · Computer Science 2024-05-22 Juan-Ni Wu , Tong Wang , Yue Chen , Li-Juan Tang , Hai-Long Wu , Ru-Qin Yu

To analyse and verify the safety and security properties of interactive systems, a formal specification might be necessary. There are many types of formal languages and frameworks. The decision regarding what type of formal specification…

Formal Languages and Automata Theory · Computer Science 2025-05-15 Maria Spichkova

We introduce Group SELFIES, a molecular string representation that leverages group tokens to represent functional groups or entire substructures while maintaining chemical robustness guarantees. Molecular string representations, such as…

Machine Learning · Computer Science 2023-10-19 Austin Cheng , Andy Cai , Santiago Miret , Gustavo Malkomes , Mariano Phielipp , Alán Aspuru-Guzik

Wall shear stress quantification is fundamental in fluid dynamics but remains challenging in wind-tunnel experiments. Sensor-based methods offer high accuracy but lack spatial resolution for capturing complex three-dimensional effects.…

Fluid Dynamics · Physics 2025-05-22 Lennart Rohlfs , Julien Weiss

Current video text spotting methods can achieve preferable performance, powered with sufficient labeled training data. However, labeling data manually is time-consuming and labor-intensive. To overcome this, using low-cost synthetic data is…

Computer Vision and Pattern Recognition · Computer Science 2023-05-08 Yuzhong Zhao , Weijia Wu , Zhuang Li , Jiahong Li , Weiqiang Wang

Voice interfaces integral to the human-computer interaction systems can benefit from speech emotion recognition (SER) to customize responses based on user emotions. Since humans convey emotions through multi-modal audio-visual cues,…

Machine Learning · Computer Science 2025-07-02 Varsha Pendyala , Pedro Morgado , William Sethares

Nowadays simulations can produce petabytes of data to be stored in parallel filesystems or large-scale databases. This data is accessed over the course of decades often by thousands of analysts and scientists. However, storing these volumes…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-02-11 Salvatore Di Girolamo , Pirmin Schmid , Thomas Schulthess , Torsten Hoefler

In the present paper we evaluated efficiency of the recent Transformer-CNN models to predict target properties based on the augmented stereochemical SMILES. We selected a well-known Cliff activity dataset as well as a Dipole moment dataset…

Quantitative Methods · Quantitative Biology 2020-10-08 Ruud van Deursen , Igor V. Tetko , Guillaume Godin

The simplified molecular-input line-entry system (SMILES) is the most popular representation of chemical compounds. Therefore, many SMILES-based molecular property prediction models have been developed. In particular, transformer-based…

Quantitative Methods · Quantitative Biology 2022-05-03 Ingoo Lee , Hojung Nam

Materials science literature contains millions of materials synthesis procedures described in unstructured natural language text. Large-scale analysis of these synthesis procedures would facilitate deeper scientific understanding of…

Computation and Language · Computer Science 2019-07-16 Sheshera Mysore , Zach Jensen , Edward Kim , Kevin Huang , Haw-Shiuan Chang , Emma Strubell , Jeffrey Flanigan , Andrew McCallum , Elsa Olivetti

In electronic design, engineers often manually search through extensive documents to retrieve component parameters required for constructing SPICE models, a process that is both labor-intensive and time-consuming. To address this challenge,…

Computation and Language · Computer Science 2025-06-05 Hong Cai Chen , Yi Pin Xu , Yang Zhang

Flow diagrams are a common tool used to help build and interpret models of dynamical systems, often in biological contexts such as consumer-resource models and similar compartmental models. Typically, their usage is intuitive and informal.…

Quantitative Methods · Quantitative Biology 2016-06-10 C. Brandon Ogbunugafor , Sean P. Robinson

The cost of combustion simulations is often dominated by the evaluation of net production rates of chemical species and mixture thermodynamics (thermochemistry). Execution on computing accelerators (XPUs) like graphic processing units…

A spreadsheet is remarkably flexible in representing various forms of structured data, but the individual cells have no knowledge of the larger structures of which they may form a part. This can hamper comprehension and increase formula…

Software Engineering · Computer Science 2018-01-29 Alan Hall , Michel Wermelinger , Tony Hirst , Santi Phithakkitnukoon