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The prediction of physicochemical properties from molecular structures is a crucial task for artificial intelligence aided molecular design. A growing number of Graph Neural Networks (GNNs) have been proposed to address this challenge.…

Machine Learning · Computer Science 2020-11-17 Shuo Zhang , Yang Liu , Lei Xie

Interpreting graph neural networks (GNNs) is difficult because message passing mixes signals and internal channels rarely align with human concepts. We study superposition, the sharing of directions by multiple features, directly in the…

Machine Learning · Computer Science 2026-01-19 Lukas Pertl , Han Xuanyuan , Pietro Liò

The crux of molecular property prediction is to generate meaningful representations of the molecules. One promising route is to exploit the molecular graph structure through Graph Neural Networks (GNNs). It is well known that both atoms and…

Quantitative Methods · Quantitative Biology 2020-06-15 Hehuan Ma , Yatao Bian , Yu Rong , Wenbing Huang , Tingyang Xu , Weiyang Xie , Geyan Ye , Junzhou Huang

Recently many efforts have been devoted to applying graph neural networks (GNNs) to molecular property prediction which is a fundamental task for computational drug and material discovery. One of major obstacles to hinder the successful…

Machine Learning · Computer Science 2021-09-27 Shuangli Li , Jingbo Zhou , Tong Xu , Dejing Dou , Hui Xiong

Graph neural networks (GNNs) are powerful machine learning models for various graph learning tasks. Recently, the limitations of the expressive power of various GNN models have been revealed. For example, GNNs cannot distinguish some…

Machine Learning · Computer Science 2021-01-19 Ryoma Sato , Makoto Yamada , Hisashi Kashima

Deep Graph Neural Networks (GNNs) are useful models for graph classification and graph-based regression tasks. In these tasks, graph pooling is a critical ingredient by which GNNs adapt to input graphs of varying size and structure. We…

Machine Learning · Computer Science 2020-06-25 Yu Guang Wang , Ming Li , Zheng Ma , Guido Montufar , Xiaosheng Zhuang , Yanan Fan

Many physical systems can be best understood as sets of discrete data with associated relationships. Where previously these sets of data have been formulated as series or image data to match the available machine learning architectures,…

The recent success of graph neural networks has significantly boosted molecular property prediction, advancing activities such as drug discovery. The existing deep neural network methods usually require large training dataset for each…

Machine Learning · Computer Science 2021-02-17 Zhichun Guo , Chuxu Zhang , Wenhao Yu , John Herr , Olaf Wiest , Meng Jiang , Nitesh V. Chawla

Global pooling layers are an essential part of Convolutional Neural Networks (CNN). They are used to aggregate activations of spatial locations to produce a fixed-size vector in several state-of-the-art CNNs. Global average pooling or…

Computer Vision and Pattern Recognition · Computer Science 2024-02-28 Vincent Christlein , Lukas Spranger , Mathias Seuret , Anguelos Nicolaou , Pavel Král , Andreas Maier

Graph Neural Network (GNN) is a popular architecture for the analysis of chemical molecules, and it has numerous applications in material and medicinal science. Current lines of GNNs developed for molecular analysis, however, do not fit…

Machine Learning · Computer Science 2019-05-27 Katsuhiko Ishiguro , Shin-ichi Maeda , Masanori Koyama

In modern computer vision tasks, convolutional neural networks (CNNs) are indispensable for image classification tasks due to their efficiency and effectiveness. Part of their superiority compared to other architectures, comes from the fact…

Machine Learning · Computer Science 2019-06-11 Vighnesh Birodkar , Hossein Mobahi , Dilip Krishnan , Samy Bengio

Property prediction on molecular graphs is an important application of Graph Neural Networks. Recently, unlabeled molecular data has become abundant, which facilitates the rapid development of self-supervised learning for GNNs in the…

Machine Learning · Computer Science 2023-10-31 Kha-Dinh Luong , Ambuj Singh

Graph Neural networks (GNNs) have recently become a powerful technique for many graph-related tasks including graph classification. Current GNN models apply different graph pooling methods that reduce the number of nodes and edges to learn…

Machine Learning · Computer Science 2023-03-08 Muhammad Ifte Khairul Islam , Max Khanov , Esra Akbas

In convolutional neural networks (CNNs), pooling operations play important roles such as dimensionality reduction and deformation compensation. In general, max pooling, which is the most widely used operation for local pooling, is performed…

Computer Vision and Pattern Recognition · Computer Science 2020-08-07 Takato Otsuzuki , Hideaki Hayashi , Yuchen Zheng , Seiichi Uchida

Recently, there has been an emerging trend to integrate persistent homology (PH) into graph neural networks (GNNs) to enrich expressive power. However, naively plugging PH features into GNN layers always results in marginal improvement with…

Machine Learning · Computer Science 2024-10-21 Chaolong Ying , Xinjian Zhao , Tianshu Yu

We aim to deepen the theoretical understanding of Graph Neural Networks (GNNs) on large graphs, with a focus on their expressive power. Existing analyses relate this notion to the graph isomorphism problem, which is mostly relevant for…

Machine Learning · Computer Science 2023-05-25 Nicolas Keriven , Samuel Vaiter

We introduce a convolutional neural network that operates directly on graphs. These networks allow end-to-end learning of prediction pipelines whose inputs are graphs of arbitrary size and shape. The architecture we present generalizes…

Convolutional neural networks (CNNs) are being applied to an increasing number of problems and fields due to their superior performance in classification and regression tasks. Since two of the key operations that CNNs implement are…

Machine Learning · Computer Science 2018-02-27 Fernando Gama , Geert Leus , Antonio G. Marques , Alejandro Ribeiro

We explore different strategies to integrate prior domain knowledge into the design of a deep neural network (DNN). We focus on graph neural networks (GNN), with a use case of estimating the potential energy of chemical systems (molecules…

Machine Learning · Computer Science 2022-08-26 Jay Morgan , Adeline Paiement , Christian Klinke

Molecular property prediction is essential in a variety of contemporary scientific fields, such as drug development and designing energy storage materials. Although there are many machine learning models available for this purpose, those…

Machine Learning · Computer Science 2025-06-03 Gihan Panapitiya , Peiyuan Gao , C Mark Maupin , Emily G Saldanha
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