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One of the main challenges in drug discovery is to find molecules that bind specifically and strongly to their target protein while having minimal binding to other proteins. By predicting binding affinity, it is possible to identify the…

Quantum Physics · Physics 2023-01-19 L. Domingo , M. Djukic , C. Johnson , F. Borondo

Quantum computing promises to solve difficult optimization problems in chemistry, physics and mathematics more efficiently than classical computers, but requires fault-tolerant quantum computers with millions of qubits. To overcome errors…

Databases · Computer Science 2021-07-23 Tobias Fankhauser , Marc E. Solèr , Rudolf M. Füchslin , Kurt Stockinger

Efficient production planning is essential in modern manufacturing to improve performance indicators such as lead time and to reduce reliance on human intuition. While mathematical optimization approaches, formulated as job shop scheduling…

Quantum Physics · Physics 2025-11-06 Kenta Sawamura , Kensuke Araki , Naoki Maruyama , Renichiro Haba , Masayuki Ohzeki

Leveraging the current generation of quantum devices to solve optimization problems of practical interest necessitates the development of hybrid quantum-classical (HQC) solution approaches. In this paper, a multi-cut Benders decomposition…

Quantum Physics · Physics 2023-02-14 Nikolaos G. Paterakis

Ising machines are next-generation computers expected to efficiently sample near-optimal solutions of combinatorial optimization problems. Combinatorial optimization problems are modeled as quadratic unconstrained binary optimization (QUBO)…

Optimization and Control · Mathematics 2024-06-21 Kentaro Ohno , Nozomu Togawa

We introduce a self-consistent mean-field quantum optimization algorithm that approximates the ground state of classical Ising Hamiltonians. The algorithm decomposes the problem into independent subproblems and treats the interactions…

Quantum Physics · Physics 2026-03-11 Maxime Dupont , Bhuvanesh Sundar , Meenambika Gowrishankar

The "folding algorithm"\cite{fold1} is a matrix product state algorithm for simulating quantum systems that involves a spatial evolution of a matrix product state. Hence, the computational effort of this algorithm is controlled by the…

Quantum Physics · Physics 2015-03-18 M. B. Hastings , R. Mahajan

This work considers the problem of optimal lane changing in a structured multi-agent road environment. A novel motion planning algorithm that can capture long-horizon dependencies as well as short-horizon dynamics is presented. Pivotal to…

Robotics · Computer Science 2024-05-07 Rudolf Reiter , Armin Nurkanovic , Daniele Bernadini , Moritz Diehl , Alberto Bemporad

This paper presents an efficient approach for the evaluation of multi-parametric mixed integer quadratic programming (mp-MIQP) solutions, occurring for instance in control problems involving discrete time hybrid systems with quadratic cost.…

Optimization and Control · Mathematics 2014-07-08 Alexander Fuchs , Daniel Axehill , Manfred Morari

The mining in physics and biology for accelerating the hardcore algorithm to solve non-deterministic polynomial (NP) hard problems has inspired a great amount of special-purpose ma-chine models. Ising machine has become an efficient solver…

Emerging Technologies · Computer Science 2022-04-06 Wenchen Sun , Wenjia Zhang , Yuanyuan Liu , Qingwen Liu , Zuyuan He

We propose a framework to solve non-linear and history-dependent mechanical problems based on a hybrid classical computer -- quantum annealer approach. Quantum Computers are anticipated to solve particular operations exponentially faster.…

Computational Engineering, Finance, and Science · Computer Science 2024-02-20 Van-Dung Nguyen , Ling Wu , Françoise Remacle , Ludovic Noels

We propose an extended variant of the reformulation and decomposition algorithm for solving a special class of mixed-integer bilevel linear programs (MIBLPs) where continuous and integer variables are involved in both upper- and lower-level…

Optimization and Control · Mathematics 2018-07-03 Dajun Yue , Jiyao Gao , Bo Zeng , Fengqi You

We introduce a methodology for generating benchmark problem sets for Ising machines---devices designed to solve discrete optimization problems cast as Ising models. In our approach, linear systems of equations are cast as Ising cost…

Quantum Physics · Physics 2019-09-02 Itay Hen

In recent years, the number of hybrid algorithms that combine quantum and classical computations has been continuously increasing. These two approaches to computing can mutually enhance each others' performances thus bringing the promise of…

The intersection between quantum computing and optimisation has been an area of interest in recent years. There have been numerous studies exploring the application of quantum and quantum-hybrid solvers to various optimisation problems.…

Quantum Physics · Physics 2024-05-29 Mayowa Ayodele

Formulation symmetry in mixed-integer programming (MIP) can hinder solver performance by inducing redundant search, but detecting such symmetries is also a significant computational challenge. This paper explores the potential for quantum…

Optimization and Control · Mathematics 2025-12-18 Alexander While , Chen Chen

Ising machines, including quantum annealing machines, are promising next-generation computers for combinatorial optimization problems. However, due to hardware limitations, most Ising-type hardware can only solve objective functions…

Statistical Mechanics · Physics 2025-10-29 Kazuki Ikeuchi , Yoshiki Matsuda , Shu Tanaka

Many combinatorial optimization problems (COPs) are naturally expressed using variables that take on more than two discrete values. To solve such problems using Ising machines (IMs) - specialized analog or digital devices designed to solve…

Statistical Mechanics · Physics 2025-08-06 Robbe De Prins , Guy Van der Sande , Peter Bienstman , Thomas Van Vaerenbergh

A standard quadratic program is an optimization problem that consists of minimizing a (nonconvex) quadratic form over the unit simplex. We focus on reformulating a standard quadratic program as a mixed integer linear programming problem. We…

Optimization and Control · Mathematics 2018-10-05 Jacek Gondzio , E. Alper Yildirim

Despite rapid recent progress towards the development of quantum computers capable of providing computational advantages over classical computers, it seems likely that such computers will, initially at least, be required to run in a hybrid…

Data Structures and Algorithms · Computer Science 2020-01-27 Alastair A. Abbott , Cristian S. Calude , Michael J. Dinneen , Richard Hua
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