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Accurate prediction of virus-host interactions is critical for understanding viral ecology and developing applications like phage therapy. However, the growing number of computational tools has created a complex landscape, making direct…

Genomics · Quantitative Biology 2025-09-03 Jiayu Shang , Cheng Peng , Jiaojiao Guan , Dehan Cai , Donglin Wang , Yanni Sun

Context: Mining software repositories is a popular means to gain insights into a software project's evolution, monitor project health, support decisions and derive best practices. Tools supporting the mining process are commonly applied by…

Software Engineering · Computer Science 2025-11-13 Nicole Hoess , Carlos Paradis , Rick Kazman , Wolfgang Mauerer

Polygenic risk score (PRS) tools differ substantially in statistical assumptions, input requirements, and implementation complexity, making direct comparison difficult. We developed a harmonized, implementation-aware benchmarking framework…

Genomics · Quantitative Biology 2026-03-24 Muhammad Muneeb , David B. Ascher

Interpretability methods aim to help users build trust in and understand the capabilities of machine learning models. However, existing approaches often rely on abstract, complex visualizations that poorly map to the task at hand or require…

Human-Computer Interaction · Computer Science 2021-07-12 Harini Suresh , Kathleen M. Lewis , John V. Guttag , Arvind Satyanarayan

There is a general belief that software must be able to easily do things that humans find difficult. Since finding sources for plagiarism in a text is not an easy task, there is a wide-spread expectation that it must be simple for software…

Observability is a modelling property that describes the possibility of inferring the internal state of a system from observations of its output. A related property, structural identifiability, refers to the theoretical possibility of…

Quantitative Methods · Quantitative Biology 2018-12-12 Alejandro F. Villaverde

A vigorous and growing set of technical debt analysis tools have been developed in recent years -- both research tools and industrial products -- such as Structure 101, SonarQube, and DV8. Each of these tools identifies problematic files…

Software Engineering · Computer Science 2021-03-09 Jason Lefever , Yuanfang Cai , Humberto Cervantes , Rick Kazman , Hongzhou Fang

Large language models (LLMs) have exhibited remarkable capabilities across various domains. The ability to call external tools further expands their capability to handle real-world tasks. However, LLMs often follow an opaque reasoning…

Machine Learning · Computer Science 2025-11-20 Ruixin Zhang , Jon Donnelly , Zhicheng Guo , Ghazal Khalighinejad , Haiyang Huang , Alina Jade Barnett , Cynthia Rudin

High-quality data is key to interpretable and trustworthy data analytics and the basis for meaningful data-driven decisions. In practical scenarios, data quality is typically associated with data preprocessing, profiling, and cleansing for…

Databases · Computer Science 2019-07-19 Lisa Ehrlinger , Elisa Rusz , Wolfram Wöß

Recent studies have adopted pre-trained language models, such as CodeT5 and CodeGPT, for automated program generation tasks like code generation, repair, and translation. Numerous language model-based approaches have been proposed and…

Software Engineering · Computer Science 2024-01-09 Yue Liu , Chakkrit Tantithamthavorn , Yonghui Liu , Li Li

The ability to use, understand, and create tools is a hallmark of human intelligence, enabling sophisticated interaction with the physical world. For any general-purpose intelligent agent to achieve true versatility, it must also master…

Computer Vision and Pattern Recognition · Computer Science 2025-10-13 Zixin Zhang , Kanghao Chen , Xingwang Lin , Lutao Jiang , Xu Zheng , Yuanhuiyi Lyu , Litao Guo , Yinchuan Li , Ying-Cong Chen

Practical identifiability is a critical concern in data-driven modeling of mathematical systems. In this paper, we propose a novel framework for practical identifiability analysis to evaluate parameter identifiability in mathematical models…

Quantitative Methods · Quantitative Biology 2026-01-06 Shun Wang , Wenrui Hao

Teaching language models to use tools is an important milestone towards building general assistants, but remains an open problem. While there has been significant progress on learning to use specific tools via fine-tuning, language models…

Computation and Language · Computer Science 2024-03-14 Dheeraj Mekala , Jason Weston , Jack Lanchantin , Roberta Raileanu , Maria Lomeli , Jingbo Shang , Jane Dwivedi-Yu

Personality determines a wide variety of human daily and working behaviours, and is crucial for understanding human internal and external states. In recent years, a large number of automatic personality computing approaches have been…

Computer Vision and Pattern Recognition · Computer Science 2024-02-07 Rongfan Liao , Siyang Song , Hatice Gunes

In light of the growing interest in type inference research for Python, both researchers and practitioners require a standardized process to assess the performance of various type inference techniques. This paper introduces TypeEvalPy, a…

Software Engineering · Computer Science 2024-01-03 Ashwin Prasad Shivarpatna Venkatesh , Samkutty Sabu , Jiawei Wang , Amir M. Mir , Li Li , Eric Bodden

Mathematics has many useful properties for developing of complex software systems. One is that it can exactly describe a physical situation of the object or outcome of an action. Mathematics support abstraction and this is an excellent…

Software Engineering · Computer Science 2010-04-19 Manoranjan Kumar Singh , Rakesh. L

While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims…

As NLP tools become ubiquitous in today's technological landscape, they are increasingly applied to languages with a variety of typological structures. However, NLP research does not focus primarily on typological differences in its…

Computation and Language · Computer Science 2020-05-04 Sophie Groenwold , Samhita Honnavalli , Lily Ou , Aesha Parekh , Sharon Levy , Diba Mirza , William Yang Wang

Vulnerability discovery and exploits detection are two wide areas of study in software engineering. This preliminary work tries to combine existing methods with machine learning techniques to define a metric classification of vulnerable…

Software Engineering · Computer Science 2014-07-23 Gabriele Modena

We discuss issues of structural and practical identifiability of partially observed differential equations which are often applied in systems biology. The development of mathematical methods to investigate structural non-identifiability has…