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In this PhD thesis, we explore and apply methods inspired by the free energy principle to two important areas in machine learning and neuroscience. The free energy principle is a general mathematical theory of the necessary…

Artificial Intelligence · Computer Science 2021-08-31 Beren Millidge

Recent advances at the intersection of control theory, neuroscience, and machine learning have revealed novel mechanisms by which dynamical systems perform computation. These advances encompass a wide range of conceptual, mathematical, and…

Machine Learning · Computer Science 2026-04-10 Arthur N. Montanari , Francesco Bullo , Dmitry Krotov , Adilson E. Motter

In this paper we show how The Free Energy Principle (FEP) can provide an explanation for why real-world networks deviate from scale-free behaviour, and how these characteristic deviations can emerge from constraints on information…

Social and Information Networks · Computer Science 2025-02-19 Peter R Williams , Zhan Chen

The Free Energy Principle (FEP) states that under suitable conditions of weak coupling, random dynamical systems with sufficient degrees of freedom will behave so as to minimize an upper bound, formalized as a variational free energy, on…

Quantum Physics · Physics 2022-07-21 Chris Fields , Karl Friston , James F. Glazebrook , Michael Levin

Scale-free and non-computable characteristics of natural networks are found to result from the least-time dispersal of energy. To consider a network as a thermodynamic system is motivated since ultimately everything that exists can be…

General Physics · Physics 2011-06-22 Tuomo Hartonen , Arto Annila

The free energy principle (FEP) is a mathematical framework that describes how biological systems self-organize and survive in their environment. This principle provides insights on multiple scales, from high-level behavioral and cognitive…

Neurons and Cognition · Quantitative Biology 2021-03-24 David Kappel , Christian Tetzlaff

Networked systems display complex patterns of interactions between a large number of components. In physical networks, these interactions often occur along structural connections that link components in a hard-wired connection topology,…

Neurons and Cognition · Quantitative Biology 2018-04-03 Jason Kim , Jonathan M. Soffer , Ari E. Kahn , Jean M. Vettel , Fabio Pasqualetti , Danielle S. Bassett

Organisms are nonequilibrium, stationary systems self-organized via spontaneous symmetry breaking and undergoing metabolic cycles with broken detailed balance in the environment. The thermodynamic free-energy principle describes an…

Neurons and Cognition · Quantitative Biology 2022-11-24 Chang Sub Kim

Conceptual and mathematical models of neurons have lagged behind empirical understanding for decades. Here we extend previous work in modeling biological systems with fully scale-independent quantum information-theoretic tools to develop a…

Neurons and Cognition · Quantitative Biology 2022-07-21 Chris Fields , James F. Glazebrook , Michael Levin

This paper presents a model of consciousness that follows directly from the free-energy principle (FEP). We first rehearse the classical and quantum formulations of the FEP. In particular, we consider the inner screen hypothesis that…

Neurons and Cognition · Quantitative Biology 2024-01-03 Maxwell J. D. Ramstead , Mahault Albarracin , Alex Kiefer , Brennan Klein , Chris Fields , Karl Friston , Adam Safron

We consider a free boundary problem for a system of PDEs, modeling the growth of a biological tissue. A morphogen, controlling volume growth, is produced by specific cells and then diffused and absorbed throughout the domain. The geometric…

Analysis of PDEs · Mathematics 2017-11-22 Alberto Bressan , Marta Lewicka

Attractor dynamics are a hallmark of many complex systems, including the brain. Understanding how such self-organizing dynamics emerge from first principles is crucial for advancing our understanding of neuronal computations and the design…

Neurons and Cognition · Quantitative Biology 2026-05-22 Tamas Spisak , Karl Friston

The free energy principle casts perception as variational inference, but its biological implementation remains underspecified. In particular, the generalized-coordinate formalism should not be read as a literal claim that neurons compute…

Neurons and Cognition · Quantitative Biology 2026-05-07 Vikas N. O'Reilly-Shah

The Free-Energy-Principle (FEP) is an influential and controversial theory which postulates a deep and powerful connection between the stochastic thermodynamics of self-organization and learning through variational inference. Specifically,…

Artificial Intelligence · Computer Science 2021-10-05 Beren Millidge , Anil Seth , Christopher L Buckley

While Moore's law has driven exponential computing power expectations, its nearing end calls for new avenues for improving the overall system performance. One of these avenues is the exploration of alternative brain-inspired computing…

Neural and Evolutionary Computing · Computer Science 2023-05-16 Charlotte Frenkel , David Bol , Giacomo Indiveri

Many important multi-component crystalline solids undergo mechanochemical spinodal decomposition: a phase transformation in which the compositional redistribution is coupled with structural changes of the crystal, resulting in dynamically…

Computational Engineering, Finance, and Science · Computer Science 2023-07-19 Xiaoxuan Zhang , Krishna Garikipati

Spatially-embedded complex networks, such as nervous systems, the Internet and transportation networks, generally have non-trivial topological patterns of connections combined with nearly minimal wiring costs. However the growth rules…

Physics and Society · Physics 2013-05-09 Vincenzo Nicosia , Petra E. Vértes , William R. Schafer , Vito Latora , Edward T. Bullmore

By using the conserved currents in the bulk space-time, we study dynamical holographic systems and the relation between thermodynamical and dynamical stability of such systems. In particular, in the probe limit a generalized free energy is…

High Energy Physics - Theory · Physics 2023-10-09 Yu Tian , Xiao-Ning Wu , Hongbao Zhang

We propose a dynamical neural network model with a hierarchical and modular structure. The network architecture can be derived by minimizing an energy function that is originally designed based on two kinds of neurons with quite different…

Neurons and Cognition · Quantitative Biology 2026-04-14 Kazuyoshi Tsutsumi , Ernst Niebur

We present a differentiable formalism for learning free energies that is capable of capturing arbitrarily complex model dependencies on coarse-grained coordinates and finite-temperature response to variation of general system parameters.…

Computational Physics · Physics 2024-05-31 Blake R. Duschatko , Xiang Fu , Cameron Owen , Yu Xie , Albert Musaelian , Tommi Jaakkola , Boris Kozinsky
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