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Renal cell carcinoma represents a significant global health challenge with a low survival rate. This research aimed to devise a comprehensive deep-learning model capable of predicting survival probabilities in patients with renal cell…

Computer Vision and Pattern Recognition · Computer Science 2023-07-10 Maryamalsadat Mahootiha , Hemin Ali Qadir , Jacob Bergsland , Ilangko Balasingham

Recent advances in large language models (LLMs) have shown strong reasoning capabilities through large-scale pretraining and post-training reinforcement learning, demonstrated by DeepSeek-R1. However, current post-training methods, such as…

Artificial Intelligence · Computer Science 2025-12-04 Boyang Gu , Hongjian Zhou , Bradley Max Segal , Jinge Wu , Zeyu Cao , Hantao Zhong , Lei Clifton , Fenglin Liu , David A. Clifton

Reinforcement Learning (RL) can be used to fit a mapping from patient state to a medication regimen. Prior studies have used deterministic and value-based tabular learning to learn a propofol dose from an observed anesthetic state. Deep RL…

Machine Learning · Computer Science 2020-09-10 Gabe Schamberg , Marcus Badgeley , Emery N. Brown

Learning to rank (LTR) plays a crucial role in various Information Retrieval (IR) tasks. Although supervised LTR methods based on fine-grained relevance labels (e.g., document-level annotations) have achieved significant success, their…

Information Retrieval · Computer Science 2025-08-21 Yiteng Tu , Zhichao Xu , Tao Yang , Weihang Su , Yujia Zhou , Yiqun Liu , Fen Lin , Qin Liu , Qingyao Ai

In recent years deep reinforcement learning (RL) systems have attained superhuman performance in a number of challenging task domains. However, a major limitation of such applications is their demand for massive amounts of training data. A…

Although reinforcement learning (RL) has tremendous success in many fields, applying RL to real-world settings such as healthcare is challenging when the reward is hard to specify and no exploration is allowed. In this work, we focus on…

Machine Learning · Computer Science 2022-06-15 Chun-Hao Chang , George Alexandru Adam , Rich Caruana , Anna Goldenberg

Deep reinforcement learning (DRL) requires the collection of interventional data, which is sometimes expensive and even unethical in the real world, such as in the autonomous driving and the medical field. Offline reinforcement learning…

Machine Learning · Computer Science 2023-06-12 Wenxuan Zhu , Chao Yu , Qiang Zhang

Developing 3D vision-language models with robust clinical reasoning remains a challenge due to the inherent complexity of volumetric medical imaging, the tendency of models to overfit superficial report patterns, and the lack of…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Haoran Lai , Zihang Jiang , Kun Zhang , Qingsong Yao , Rongsheng Wang , Zhiyang He , Xiaodong Tao , Wei Wei , Shaohua Kevin Zhou

Many healthcare decisions involve navigating through a multitude of treatment options in a sequential and iterative manner to find an optimal treatment pathway with the goal of an optimal patient outcome. Such optimization problems may be…

Machine Learning · Computer Science 2021-03-10 Elsa Riachi , Muhammad Mamdani , Michael Fralick , Frank Rudzicz

This paper proposes a robust control design method using reinforcement-learning for controlling partially-unknown dynamical systems under uncertain conditions. The method extends the optimal reinforcement-learning algorithm with a new…

Systems and Control · Electrical Eng. & Systems 2020-04-17 Phuong D. Ngo , Fred Godtliebsen

Managing physiological variables within clinically safe target zones is a central challenge in healthcare, particularly for chronic conditions such as Type 1 Diabetes Mellitus (T1DM). Reinforcement learning (RL) offers promise for…

Machine Learning · Computer Science 2025-08-07 David H. Mguni , Jing Dong , Wanrong Yang , Ziquan Liu , Muhammad Salman Haleem , Baoxiang Wang

Sepsis is the leading cause of mortality in the ICU. It is challenging to manage because individual patients respond differently to treatment. Thus, tailoring treatment to the individual patient is essential for the best outcomes. In this…

Mechanical ventilation is a key form of life support for patients with pulmonary impairment. Healthcare workers are required to continuously adjust ventilator settings for each patient, a challenging and time consuming task. Hence, it would…

Machine Learning · Computer Science 2022-10-07 Flemming Kondrup , Thomas Jiralerspong , Elaine Lau , Nathan de Lara , Jacob Shkrob , My Duc Tran , Doina Precup , Sumana Basu

Reinforcement Learning (RL) applied in healthcare can lead to unsafe medical decisions and treatment, such as excessive dosages or abrupt changes, often due to agents overlooking common-sense constraints. Consequently, Constrained…

Machine Learning · Computer Science 2024-10-15 Nan Fang , Guiliang Liu , Wei Gong

This paper presents a real time, data driven decision support framework for epidemic control. We combine a compartmental epidemic model with sequential Bayesian inference and reinforcement learning (RL) controllers that adaptively choose…

Methodology · Statistics 2025-11-25 Giacomo Iannucci , Petros Barmpounakis , Alexandros Beskos , Nikolaos Demiris

The increased use of electronic health records has made possible the automated extraction of medical policies from patient records to aid in the development of clinical decision support systems. We adapted a boosted Statistical Relational…

Artificial Intelligence · Computer Science 2020-01-14 Michael A. Skinner , Lakshmi Raman , Neel Shah , Abdelaziz Farhat , Sriraam Natarajan

Reinforcement Learning (RL) offers a powerful framework for optimizing dynamic treatment regimes (DTRs). However, clinical RL is fundamentally bottlenecked by reward engineering: the challenge of defining signals that safely and effectively…

Machine Learning · Computer Science 2026-02-05 Qianyi Xu , Gousia Habib , Feng Wu , Yanrui Du , Zhihui Chen , Swapnil Mishra , Dilruk Perera , Mengling Feng

Dynamic treatment recommendation systems based on large-scale electronic health records (EHRs) become a key to successfully improve practical clinical outcomes. Prior relevant studies recommend treatments either use supervised learning…

Machine Learning · Computer Science 2018-09-18 Lu Wang , Wei Zhang , Xiaofeng He , Hongyuan Zha

Reinforcement learning (RL) algorithms usually require a substantial amount of interaction data and perform well only for specific tasks in a fixed environment. In some scenarios such as healthcare, however, usually only few records are…

Machine Learning · Computer Science 2020-12-17 Chaochao Lu , Biwei Huang , Ke Wang , José Miguel Hernández-Lobato , Kun Zhang , Bernhard Schölkopf

Sepsis is a leading cause of mortality in intensive care units (ICUs) and costs hospitals billions annually. Treating a septic patient is highly challenging, because individual patients respond very differently to medical interventions and…

Machine Learning · Computer Science 2017-05-24 Aniruddh Raghu , Matthieu Komorowski , Leo Anthony Celi , Peter Szolovits , Marzyeh Ghassemi