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Incorporating historical data or real-world evidence has a great potential to improve the efficiency of phase I clinical trials and to accelerate drug development. For model-based designs, such as the continuous reassessment method (CRM),…

Methodology · Statistics 2020-06-11 Yanhong Zhou , J. Jack Lee , Shunguang Wang , Stuart Bailey , Ying Yuan

The subject of this work is quantum predicative programming -- the study of developing of programs intended for execution on a quantum computer. We look at programming in the context of formal methods of program development, or programming…

Quantum Physics · Physics 2008-02-19 Anya Tafliovich , E. C. R. Hehner

Quantum state discrimination underlies various applications in quantum information processing tasks. It essentially describes the distinguishability of quantum systems in different states, and the general process of extracting classical…

Quantum Physics · Physics 2017-07-12 Joonwoo Bae , Leong-Chuan Kwek

Quantum Computing (QC) claims to improve the efficiency of solving complex problems, compared to classical computing. When QC is integrated with Machine Learning (ML), it creates a Quantum Machine Learning (QML) system. This paper aims to…

Quantum Physics · Physics 2025-06-11 Kamila Zaman , Alberto Marchisio , Muhammad Abdullah Hanif , Muhammad Shafique

Recent years have seen unprecedented advance in the design and control of quantum computers. Nonetheless, their applicability is still restricted and access remains expensive. Therefore, a substantial amount of quantum algorithms research…

Quantum Physics · Physics 2020-12-11 Thomas Grurl , Richard Kueng , Jürgen Fuß , Robert Wille

Quantum Machine Learning (QML) represents a promising frontier at the intersection of quantum computing and artificial intelligence, aiming to leverage quantum computational advantages to enhance data-driven tasks. This review explores the…

Machine Learning · Computer Science 2025-07-14 Samarth Kashyap , Rohit K Ramakrishnan , Kumari Jyoti , Apoorva D Patel

Molecule generation and optimization is a fundamental task in chemical domain. The rapid development of intelligent tools, especially large language models (LLMs) with powerful knowledge reserves and interactive capabilities, has provided…

Machine Learning · Computer Science 2026-02-10 Haoran Liu , Zheni Zeng , Yukun Yan , Yuxuan Chen , Yunduo Xiao

The US Food and Drug Administration launched Project Optimus with the aim of shifting the paradigm of dose-finding and selection towards identifying the optimal biological dose that offers the best balance between benefit and risk, rather…

Methodology · Statistics 2023-09-13 Ying Yuan , Heng Zhou , Suyu Liu

Current clinical decision-making in oncology relies on averages of large patient populations to both assess tumor status and treatment outcomes. However, cancers exhibit an inherent evolving heterogeneity that requires an individual…

This article provides recommendations for implementing quantitative susceptibility mapping (QSM) for clinical brain research. It is a consensus of the ISMRM Electro-Magnetic Tissue Properties Study Group. While QSM technical development…

A common practice in evidence-based decision-making uses estimates of conditional probabilities P(y|x) obtained from research studies to predict outcomes y on the basis of observed covariates x. Given this information, decisions are then…

Econometrics · Economics 2025-12-08 Atheendar S. Venkataramani , Charles F. Manski , John Mullahy

The present communication addresses a set of observations, obeying both deterministic as well as statistical formal requirements, and serving to operate within the framework of the dynamical systems theory, with a certain emphasis placed on…

Physics and Society · Physics 2017-06-30 Adam Gadomski , Marcel Ausloos , Tahlia Casey

The ability to make decisions based on data, with its inherent uncertainties and variability, is a complex and vital skill in the modern world. The need for such quantitative critical thinking occurs in many different contexts, and while it…

Physics Education · Physics 2015-08-21 N. G. Holmes , Carl E. Wieman , D. A. Bonn

We are witnessing the birth of a new variety of pharmacokinetics where non-integer-order differential equations are employed to study the time course of drugs in the body: this is dubbed "fractional pharmacokinetics." The presence of…

Dynamical Systems · Mathematics 2019-04-25 Pantelis Sopasakis , Haralambos Sarimveis , Panos Macheras , Aristides Dokoumetzidis

A new type of experiment that aims to determine the optimal quantities of a sequence of factors is eliciting considerable attention in medical science, bioengineering, and many other disciplines. Such studies require the simultaneous…

Methodology · Statistics 2022-09-14 Qian Xiao , Yaping Wang , Abhyuday Mandal , Xinwei Deng

Quantum Decision Theory, advanced earlier by the authors, and illustrated for lotteries with gains, is generalized to the games containing lotteries with gains as well as losses. The mathematical structure of the approach is based on the…

Physics and Society · Physics 2018-02-20 V. I. Yukalov , D. Sornette

Quantiles are very important statistics information used to describe the distribution of datasets. Given the quantiles of a dataset, we can easily know the distribution of the dataset, which is a fundamental problem in data analysis.…

Databases · Computer Science 2015-08-25 Zixuan Zhuang

Generative models for quantum data pose significant challenges but hold immense potential in fields such as chemoinformatics and quantum physics. Quantum denoising diffusion probabilistic models (QuDDPMs) enable efficient learning of…

Quantum Physics · Physics 2026-03-03 Quoc Hoan Tran , Koki Chinzei , Yasuhiro Endo , Hirotaka Oshima

We present QDK/Chemistry, a software toolkit for quantum chemistry workflows targeting quantum computers. The toolkit addresses a key challenge in the field: while quantum algorithms for chemistry have matured considerably, the…

We introduce a QPLEX Decision Process (QDP) as a model for dynamic control of queueing systems with non-stationary arrivals, general service distributions, and service-level chance constraints. QDPs integrate QPLEX, a computational modeling…

Optimization and Control · Mathematics 2026-05-19 Antonius B. Dieker , Steven T. Hackman , Zitong Wang , Yunhao Yan