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Recent advances in molecular and genetic research have identified a diverse range of brain tumor sub-types, shedding light on differences in their molecular mechanisms, heterogeneity, and origins. The present study performs whole-brain…

Neurons and Cognition · Quantitative Biology 2024-07-26 Debanjali Bhattacharya , Ninad Aithal , Manish Jayswal , Neelam Sinha

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

Graph theory has drawn a lot of attention in the field of Neuroscience during the last decade, mainly due to the abundance of tools that it provides to explore the interactions of elements in a complex network like the brain. The local and…

Neurons and Cognition · Quantitative Biology 2016-11-16 Sofia Ira Ktena , Sarah Parisot , Jonathan Passerat-Palmbach , Daniel Rueckert

Functional Connectivity (FC) matrices measure the regional interactions in the brain and have been widely used in neurological brain disease classification. However, a FC matrix is neither a natural image which contains shape and texture…

Medical Physics · Physics 2020-01-10 Xiaodan Xing , Qingfeng Li , Hao Wei , Minqing Zhang , Yiqiang Zhan , Xiang Sean Zhou , Zhong Xue , Feng Shi

Recently, graph theory has become a popular method for characterizing brain functional organization. One important goal in graph theoretical analysis of brain networks is to identify network differences across disease types or conditions.…

Applications · Statistics 2018-10-01 Ixavier A Higgins , Ying Guo , Suprateek Kundu , Ki Sueng Choi , Helen Mayberg

The brain's functional connectivity fluctuates over time instead of remaining steady in a stationary mode even during the resting state. This fluctuation establishes the dynamical functional connectivity that transitions in a non-random…

Neurons and Cognition · Quantitative Biology 2022-03-28 Shikuang Deng , Jingwei Li , B. T. Thomas Yeo , Shi Gu

Understanding brain dynamics and functions critically depends on knowledge of the network connectivity among neurons. However, the complexity of brain structural connectivity, coupled with continuous modifications driven by synaptic…

Neurons and Cognition · Quantitative Biology 2025-07-04 Kai Chen , Mingzhang Wang , Songting Li , Douglas Zhou

Activity in the human brain moves between diverse functional states to meet the demands of our dynamic environment, but fundamental principles guiding these transitions remain poorly understood. Here, we capitalize on recent advances in…

We tackle classification based on brain connectivity derived from diffusion magnetic resonance images. We propose a machine-learning model inspired by graph convolutional networks (GCNs), which takes a brain connectivity input graph and…

Neurons and Cognition · Quantitative Biology 2023-09-21 Anees Kazi , Jocelyn Mora , Bruce Fischl , Adrian V. Dalca , Iman Aganj

The brain structural connectome is generated by a collection of white matter fiber bundles constructed from diffusion weighted MRI (dMRI), acting as highways for neural activity. There has been abundant interest in studying how the…

Methodology · Statistics 2022-11-03 Didong Li , Phuc Nguyen , Zhengwu Zhang , David B Dunson

Node-link diagrams are widely used to visualise networks. However, even the best network layout algorithms ultimately result in 'hairball' visualisations when the graph reaches a certain degree of complexity, requiring simplification…

Human-Computer Interaction · Computer Science 2021-03-25 Vahan Yoghourdjian , Yalong Yang , Tim Dwyer , Lee Lawrence , Michael Wybrow , Kim Marriott

Traditional causal connectivity methods in task-based and resting-state functional magnetic resonance imaging (fMRI) face challenges in accurately capturing directed information flow due to their sensitivity to noise and inability to model…

Neurons and Cognition · Quantitative Biology 2025-04-03 Boseong Kim , Debashis Das Chakladar , Haejun Chung , Ikbeom Jang

Autism spectrum disorder (ASD) is a neurodevelopmental condition impacting high-level cognitive processing and social behavior. Recognizing the distributed nature of brain function, neuroscientists are exploiting the connectome to aid with…

Neurons and Cognition · Quantitative Biology 2019-09-26 Ai Wern Chung , Markus D. Schirmer

Encoding brain regions and their connections as a network of nodes and edges captures many of the possible paths along which information can be transmitted as humans process and perform complex behaviors. Because cognitive processes involve…

Neurons and Cognition · Quantitative Biology 2016-12-21 Ann Sizemore , Chad Giusti , Ari Kahn , Richard F. Betzel , Danielle S. Bassett

Dynamic networks have been increasingly used to characterize brain connectivity that varies during resting and task states. In such characterizations, a connectivity network is typically measured at each time point for a subject over a…

Methodology · Statistics 2023-03-23 Maoyu Zhang , Biao Cai , Wenlin Dai , Dehan Kong , Hongyu Zhao , Jingfei Zhang

Recovering brain connectivity from tract tracing data is an important computational problem in the neurosciences. Mesoscopic connectome reconstruction was previously formulated as a structured matrix regression problem (Harris et al.,…

Numerical Analysis · Mathematics 2019-11-04 Patrick Kürschner , Sergey Dolgov , Kameron Decker Harris , Peter Benner

Structure entails function and thus a structural description of the brain will help to understand its function and may provide insights into many properties of brain systems, from their robustness and recovery from damage, to their dynamics…

Neurons and Cognition · Quantitative Biology 2008-08-27 Marcus Kaiser , Robert Martin , Peter Andras , Malcolm P. Young

Brain structural networks are often represented as discrete adjacency matrices with elements summarizing the connectivity between pairs of regions of interest (ROIs). These ROIs are typically determined a-priori using a brain atlas. The…

Computation · Statistics 2023-08-11 William Consagra , Martin Cole , Xing Qiu , Zhengwu Zhang

We analyze the complex networks associated with brain electrical activity. Multichannel EEG measurements are first processed to obtain 3D voxel activations using the tomographic algorithm LORETA. Then, the correlation of the current…

Biological Physics · Physics 2007-05-23 G. Ruffini , C. Ray , J. Marco , L. Fuentemilla , C. Grau

We introduce a probabilistic framework that represents stylized banking networks with the aim of predicting the size of contagion events. Most previous work on random financial networks assumes independent connections between banks, whereas…

Physics and Society · Physics 2017-04-12 Thomas R. Hurd , James P. Gleeson , Sergey Melnik