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Biologically-informed neural networks (BINNs), an extension of physics-informed neural networks [1], are introduced and used to discover the underlying dynamics of biological systems from sparse experimental data. In the present work, BINNs…

Quantitative Methods · Quantitative Biology 2021-01-27 John H. Lagergren , John T. Nardini , Ruth E. Baker , Matthew J. Simpson , Kevin B. Flores

The neutron diffusion equation plays a pivotal role in the analysis of nuclear reactors. Nevertheless, employing the Physics-Informed Neural Network (PINN) method for its solution entails certain limitations. Traditional PINN approaches…

Machine Learning · Computer Science 2024-07-17 Heng Zhang , Yun-Ling He , Dong Liu , Qin Hang , He-Min Yao , Di Xiang

The development of biophysical models for clinical applications is rapidly advancing in the research community, thanks to their predictive nature and their ability to assist the interpretation of clinical data. However, high-resolution and…

This paper proposes a meshless deep learning algorithm, enriched physics-informed neural networks (EPINNs), to solve dynamic Poisson-Nernst-Planck (PNP) equations with strong coupling and nonlinear characteristics. The EPINNs takes the…

Machine Learning · Computer Science 2024-02-06 Xujia Huang , Fajie Wang , Benrong Zhang , Hanqing Liu

Inferring biophysical parameters and hidden state variables from partial and noisy observations is a fundamental challenge in computational neuroscience. This problem is particularly difficult for fast - slow spiking and bursting models,…

Neural and Evolutionary Computing · Computer Science 2026-03-11 Changliang Wei , Yangyang Wang , Xueyu Zhu

Physics-informed neural networks (PINN) face significant challenges from spectral bias, which impedes their ability to model high-frequency phenomena and limits extrapolation performance. To address this, we introduce xLSTM-PINN, a novel…

Machine Learning · Computer Science 2025-12-08 Ze Tao , Darui Zhao , Fujun Liu , Ke Xu , Xiangsheng Hu

We propose a new physics-informed neural network framework, IDPINN, based on the enhancement of initialization and domain decomposition to improve prediction accuracy. We train a PINN using a small dataset to obtain an initial network…

Machine Learning · Computer Science 2024-06-06 Chenhao Si , Ming Yan

Physics-Informed Neural Networks (PINNs) have emerged as a powerful tool for solving partial differential equations~(PDEs) in various scientific and engineering domains. However, traditional PINN architectures typically rely on large, fully…

Computational Engineering, Finance, and Science · Computer Science 2024-04-22 Stefano Markidis

Digital Image Correlation (DIC) is a key technique in experimental mechanics for full-field deformation measurement, traditionally relying on subset matching to determine displacement fields. However, selecting optimal parameters like shape…

Image and Video Processing · Electrical Eng. & Systems 2024-09-04 Boda Li , Shichao Zhou , Qinwei Ma , Shaopeng Ma

Structured illumination microscopy (SIM) is a wide-field super-resolution technique normally limited to roughly twice the diffraction-limited resolution ($\approx 100$--$200$~nm). Surpassing this bound is a classic ill-posed inverse…

Physics-Informed Neural Networks (PINNs) have recently emerged as a novel approach to simulate complex physical systems on the basis of both data observations and physical models. In this work, we investigate the use of PINNs for various…

Analysis of PDEs · Mathematics 2024-03-27 Guillaume Coulaud , Maxime Le , Régis Duvigneau

A physics-informed neural network (PINN) uses physics-augmented loss functions, e.g., incorporating the residual term from governing partial differential equations (PDEs), to ensure its output is consistent with fundamental physics laws.…

Machine Learning · Computer Science 2022-12-16 Jian Cheng Wong , Chinchun Ooi , Abhishek Gupta , Yew-Soon Ong

We introduce Structure Informed Neural Networks (SINNs), a novel method for solving boundary observation problems involving PDEs. The SINN methodology is a data-driven framework for creating approximate solutions to internal variables on…

Fluid Dynamics · Physics 2023-10-31 Jakub Horsky , Andrew Wynn

We apply Physics-Informed Neural Networks (PINNs) for solving identification problems of nonhomogeneous materials. We focus on the problem with a background in elasticity imaging, where one seeks to identify the nonhomogeneous mechanical…

Machine Learning · Computer Science 2020-09-11 Enrui Zhang , Minglang Yin , George Em Karniadakis

Deep learning methods are highly effective for many image reconstruction tasks. However, the performance of supervised learned models can degrade when applied to distinct experimental settings at test time or in the presence of distribution…

Image and Video Processing · Electrical Eng. & Systems 2024-12-30 Shijun Liang , Evan Bell , Avrajit Ghosh , Saiprasad Ravishankar

Differential equations are indispensable to engineering and hence to innovation. In recent years, physics-informed neural networks (PINN) have emerged as a novel method for solving differential equations. PINN method has the advantage of…

Computational Engineering, Finance, and Science · Computer Science 2022-01-07 Mayank Raj , Pramod Kumbhar , Ratna Kumar Annabattula

Structured illumination microscopy (SIM) provides images of fluorescent objects at an enhanced resolution greater than that of conventional epifluorescence wide-field microscopy. Initially demonstrated in 1999 to enhance the lateral…

Optics · Physics 2022-03-09 James D. Manton

Deep neural networks have emerged as effective tools for computational imaging including quantitative phase microscopy of transparent samples. To reconstruct phase from intensity, current approaches rely on supervised learning with training…

Image and Video Processing · Electrical Eng. & Systems 2020-01-28 Emrah Bostan , Reinhard Heckel , Michael Chen , Michael Kellman , Laura Waller

Artificial intelligence has revolutionized optical device design, overcoming the efficiency bottlenecks of traditional methods. For holographic metasurfaces, conventional iterative algorithms suffer from time-consuming iterations and…

In recent engineering applications using deep learning, physics-informed neural network (PINN) is a new development as it can exploit the underlying physics of engineering systems. The novelty of PINN lies in the use of partial differential…

Computational Engineering, Finance, and Science · Computer Science 2026-02-26 Kart Leong Lim , Rahul Dutta , Mihai Rotaru