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We introduce the Kernel-Elastic Autoencoder (KAE), a self-supervised generative model based on the transformer architecture with enhanced performance for molecular design. KAE is formulated based on two novel loss functions: modified…

Machine Learning · Computer Science 2024-03-26 Haote Li , Yu Shee , Brandon Allen , Federica Maschietto , Victor Batista

We propose a variational autoencoder (VAE) approach for parameter estimation in nonlinear mixed-effects models based on ordinary differential equations (NLME-ODEs) using longitudinal data from multiple subjects. In moderate dimensions,…

Methodology · Statistics 2026-02-11 Zhe Li , Mélanie Prague , Rodolphe Thiébaut , Quentin Clairon

We propose a theoretical approach towards the training numerical stability of Variational AutoEncoders (VAE). Our work is motivated by recent studies empowering VAEs to reach state of the art generative results on complex image datasets.…

Machine Learning · Computer Science 2021-06-28 David Dehaene , Rémy Brossard

Type Ia supernovae (SNeIa), the thermonuclear explosions of C/O white dwarf stars in binary systems, are phenomena that remain poorly understood. The complexity of their progenitor systems, explosion physics and intrinsic diversity poses…

SN 2011fe was the nearest and best-observed type Ia supernova in a generation, and brought previous incomplete datasets into sharp contrast with the detailed new data. In retrospect, documenting spectroscopic behaviors of type Ia supernovae…

High Energy Astrophysical Phenomena · Physics 2014-02-27 J. Parrent , B. Friesen , M. Parthasarathy

Variational autoencoders (VAEs) have been used extensively to discover low-dimensional latent factors governing neural activity and animal behavior. However, without careful model selection, the uncovered latent factors may reflect noise in…

Machine Learning · Computer Science 2023-12-13 Julia Huiming Wang , Dexter Tsin , Tatiana Engel

Conditional neural processes (CNPs) are a flexible and efficient family of models that learn to learn a stochastic process from data. They have seen particular application in contextual image completion - observing pixel values at some…

Machine Learning · Computer Science 2024-02-20 Victor Prokhorov , Ivan Titov , N. Siddharth

We introduce the concept of a Modular Autoencoder (MAE), capable of learning a set of diverse but complementary representations from unlabelled data, that can later be used for supervised tasks. The learning of the representations is…

Machine Learning · Computer Science 2015-11-24 Henry W J Reeve , Gavin Brown

Type Ia supernovae (SNe Ia) provide us with a unique tool for measuring extragalactic distances and determining cosmological parameters. As a result, the precise and effective calibration for peak luminosities of SNe Ia becomes extremely…

Astrophysics · Physics 2016-08-30 Xiaofeng Wang , Lifan Wang , Xu Zhou , Yuqing Lou , Zongwei Li

Recent work in synthetic data generation in the time-series domain has focused on the use of Generative Adversarial Networks. We propose a novel architecture for synthetically generating time-series data with the use of Variational…

Machine Learning · Computer Science 2021-12-08 Abhyuday Desai , Cynthia Freeman , Zuhui Wang , Ian Beaver

Masked autoencoder (MAE), a simple and effective self-supervised learning framework based on the reconstruction of masked image regions, has recently achieved prominent success in a variety of vision tasks. Despite the emergence of…

Machine Learning · Computer Science 2023-06-09 Lingjing Kong , Martin Q. Ma , Guangyi Chen , Eric P. Xing , Yuejie Chi , Louis-Philippe Morency , Kun Zhang

Type Ia supernovae (SNe Ia) are standarizable candles whose observed light curves can be used to infer their distances, which can in turn be used in cosmological analyses. As the quantity of observed SNe Ia grows with current and upcoming…

Instrumentation and Methods for Astrophysics · Physics 2024-10-29 Ana Sofía M. Uzsoy , Stephen Thorp , Matthew Grayling , Kaisey S. Mandel

Recently, autoencoders (AEs) have gained interest for creating parametric and invertible projections of multidimensional data. Parametric projections make it possible to embed new, unseen samples without recalculating the entire projection,…

Machine Learning · Computer Science 2025-11-26 Frederik L. Dennig , Daniel A. Keim

Biological sequence design (DNA, RNA, or peptides) with desired functional properties has applications in discovering novel nanomaterials, biosensors, antimicrobial drugs, and beyond. One common challenge is the ability to optimize complex…

Quantitative Methods · Quantitative Biology 2025-12-17 Elham Sadeghi , Xianqi Deng , I-Hsin Lin , Stacy M. Copp , Petko Bogdanov

Recent methods for self-supervised learning can be grouped into two paradigms: contrastive and non-contrastive approaches. Their success can largely be attributed to data augmentation pipelines which generate multiple views of a single…

Machine Learning · Computer Science 2022-02-08 William Falcon , Ananya Harsh Jha , Teddy Koker , Kyunghyun Cho

This paper introduces the Procedural (audio) Variational autoEncoder (ProVE) framework as a general approach to learning Procedural Audio PA models of environmental sounds with an improvement to the realism of the synthesis while…

Sound · Computer Science 2023-03-07 Danzel Serrano , Mark Cartwright

Variational Autoencoders (VAE) are popular generative models used to sample from complex data distributions. Despite their empirical success in various machine learning tasks, significant gaps remain in understanding their theoretical…

Machine Learning · Statistics 2025-12-23 Sobihan Surendran , Antoine Godichon-Baggioni , Sylvain Le Corff

Deep metric learning aims to learn an embedding space, where semantically similar samples are close together and dissimilar ones are repelled against. To explore more hard and informative training signals for augmentation and…

Computer Vision and Pattern Recognition · Computer Science 2022-11-30 Zheren Fu , Zhendong Mao , Bo Hu , An-An Liu , Yongdong Zhang

With the advent of large dedicated Type Ia supernova (SN Ia) surveys, K-corrections of SNe Ia and their uncertainties have become especially important in the determination of cosmological parameters. While K-corrections are largely driven…

Machine learning (ML) models trained to detect physical-layer threats on one optical fiber system often fail catastrophically when applied to a different system, due to variations in operating wavelength, fiber properties, and network…

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