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Mixed-integer programming (MIP) is a well-established framework for computer-aided molecular design (CAMD). By precisely encoding the molecular space and score functions, e.g., a graph neural network, the molecular design problem is…

Computational Engineering, Finance, and Science · Computer Science 2024-11-26 Shiqiang Zhang , Christian W. Feldmann , Frederik Sandfort , Miriam Mathea , Juan S. Campos , Ruth Misener

Influence diagrams represent decision-making problems with interdependencies between random events, decisions, and consequences. Traditionally, they have been solved using algorithms that determine the expected utility-maximizing decision…

Optimization and Control · Mathematics 2026-01-14 Topias Terho , Fabricio Oliveira , Ahti Salo , Pedro Munari

This paper investigates a combinatorial optimization problem motived from a secure power network design application in [D\'{a}n and Sandberg 2010]. Two equivalent graph optimization formulations are derived. One of the formulations is a…

Optimization and Control · Mathematics 2017-02-28 Kin Cheong Sou , Jie Lu

We present a new mixed-integer programming (MIP) approach for offline multiple change-point detection by casting the problem as a globally optimal piecewise linear (PWL) fitting problem. Our main contribution is a family of strengthened MIP…

Optimization and Control · Mathematics 2026-02-13 Apoorva Narula , Santanu S. Dey , Yao Xie

We propose a mixed-integer quadratic programming (QP) solver that is suitable for use in embedded applications, for example, hybrid model predictive control (MPC). The solver is based on the branch-and-bound method, and uses a recently…

Optimization and Control · Mathematics 2022-11-24 Daniel Arnström , Daniel Axehill

The alternating-current unit commitment problem provides a realistic representation of power system operations, which is a nonconvex mixed-integer nonlinear programming problem and hence is computationally intractable. A common relaxation…

Optimization and Control · Mathematics 2026-04-07 Yongzheng Dai

Markov Decision Processes (MDPs) are stochastic optimization problems that model situations where a decision maker controls a system based on its state. Partially observed Markov decision processes (POMDPs) are generalizations of MDPs where…

Optimization and Control · Mathematics 2019-03-26 Victor Cohen , Axel Parmentier

Mixed-Integer Programs (MIPs) are NP-hard optimization models that arise in a broad range of decision-making applications, including finance, logistics, energy systems, and network design. Although modern commercial solvers have achieved…

Mixed-integer model predictive control (MI-MPC) requires the solution of a mixed-integer quadratic program (MIQP) at each sampling instant under strict timing constraints, where part of the state and control variables can only assume a…

Optimization and Control · Mathematics 2019-03-22 Pedro Hespanhol , Rien Quirynen , Stefano Di Cairano

Motivated by recent advances in solution methods for mixed-integer convex optimization (MICP), we study the fundamental and open question of which sets can be represented exactly as feasible regions of MICP problems. We establish several…

Optimization and Control · Mathematics 2021-10-26 Miles Lubin , Juan Pablo Vielma , Ilias Zadik

Robust optimization is a framework for modeling optimization problems involving data uncertainty and during the last decades has been an area of active research. If we focus on linear programming (LP) problems with i) uncertain data, ii)…

Numerical Analysis · Computer Science 2017-02-15 Roberto Mínguez , Víctor Casero-Alonso

The thermal unit commitment (UC) problem has historically been formulated as a mixed integer quadratic programming (MIQP), which is difficult to solve efficiently, especially for large-scale systems. The tighter characteristic reduces the…

Optimization and Control · Mathematics 2022-09-26 Linfeng Yang , Shifei Chen , Zhaoyang Dong

We develop a real-time feasible mixed-integer programming-based decision making (MIP-DM) system for automated driving. Using a linear vehicle model in a road-aligned coordinate frame, the lane change constraints, collision avoidance and…

Optimization and Control · Mathematics 2023-08-22 Rien Quirynen , Sleiman Safaoui , Stefano Di Cairano

We consider integer programming problems with bounded general-integer variables belonging to the general class of network flow problems. For those, we computationally investigate the effect on mixed-integer linear programming (MIP) solvers…

Optimization and Control · Mathematics 2026-04-09 Pierre Bonami , Sanjeeb Dash , Anton Derkach , Andrea Lodi

Mixed-Integer Quadratically Constrained Quadratic Programs arise in a variety of applications, particularly in energy, water, and gas systems, where discrete decisions interact with nonconvex quadratic constraints. These problems are…

Optimization and Control · Mathematics 2025-09-24 Ignacio Gómez-Casares , Pietro Belotti , Bissan Ghaddar , Julio González-Díaz

With increased reliance on cyber infrastructure, large scale power networks face new challenges owing to computational scalability. In this paper we focus on developing an asynchronous decentralized solution framework for the Unit…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-04-15 Paritosh Ramanan , Murat Yildirim , Edmond Chow , Nagi Gebraeel

Nonlinear power flow constraints render a variety of power system optimization problems computationally intractable. Emerging research shows, however, that the nonlinear AC power flow equations can be successfully modeled using Neural…

Machine Learning · Computer Science 2021-11-01 Alyssa Kody , Samuel Chevalier , Spyros Chatzivasileiadis , Daniel Molzahn

This paper proposes a procedure to solve combinatorial power network design problems such as phasor measurement unit (PMU) placement and protection assignment against cyber-physical attacks. The proposed approach tackles the design problems…

Optimization and Control · Mathematics 2016-02-19 Kin Cheong Sou

Ordered Binary Decision Diagrams (OBDDs) are a data structure that is used in an increasing number of fields of Computer Science (e.g., logic synthesis, program verification, data mining, bioinformatics, and data protection) for…

Data Structures and Algorithms · Computer Science 2015-02-05 Anna Bernasconi , Valentina Ciriani , Lorenzo Lago

Many problems of interest for cyber-physical network systems can be formulated as Mixed-Integer Linear Programs in which the constraints are distributed among the agents. In this paper we propose a distributed algorithmic framework to solve…

Optimization and Control · Mathematics 2019-06-05 Andrea Testa , Alessandro Rucco , Giuseppe Notarstefano