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Generative models such as Large Language Models, Diffusion Models, and generative adversarial networks have recently revolutionized the creation of synthetic data, offering scalable solutions to data scarcity, privacy, and annotation…

Machine Learning · Computer Science 2025-08-28 Dawei Li , Yue Huang , Ming Li , Tianyi Zhou , Xiangliang Zhang , Huan Liu

Previous efforts to support creative problem-solving have included (a) techniques (such as brainstorming and design thinking) to stimulate creative ideas, and (b) software tools to record and share these ideas. Now, generative AI…

Generative AI (GenAI) models excel in their ability to recognize patterns in existing data and generate new and unexpected content. Recent advances have motivated applications of GenAI tools (e.g., Stable Diffusion, ChatGPT) to professional…

Human-Computer Interaction · Computer Science 2023-06-05 Matthew K. Hong , Shabnam Hakimi , Yan-Ying Chen , Heishiro Toyoda , Charlene Wu , Matt Klenk

Generative models for structure-based molecular design hold significant promise for drug discovery, with the potential to speed up the hit-to-lead development cycle, while improving the quality of drug candidates and reducing costs. Data…

Machine Learning · Statistics 2022-04-25 Lucian Chan , Rajendra Kumar , Marcel Verdonk , Carl Poelking

Discovering functional crystalline materials entails navigating an immense combinatorial design space. While recent advances in generative artificial intelligence have enabled the sampling of chemically plausible compositions and…

Machine Learning · Computer Science 2025-11-11 Hyunsoo Park , Aron Walsh

Accelerated discovery with machine learning (ML) has begun to provide the advances in efficiency needed to overcome the combinatorial challenge of computational materials design. Nevertheless, ML-accelerated discovery both inherits the…

Materials Science · Physics 2022-05-09 Chenru Duan , Fang Liu , Aditya Nandy , Heather J. Kulik

Data science models, although successful in a number of commercial domains, have had limited applicability in scientific problems involving complex physical phenomena. Theory-guided data science (TGDS) is an emerging paradigm that aims to…

Developing new metal hydrides is a critical step toward efficient hydrogen storage in carbon-neutral energy systems. However, existing materials databases, such as the Materials Project, contain a limited number of well-characterized…

Machine Learning · Computer Science 2026-01-30 Xiyuan Liu , Christian Hacker , Shengnian Wang , Yuhua Duan

We consider multi-solution optimization and generative models for the generation of diverse artifacts and the discovery of novel solutions. In cases where the domain's factors of variation are unknown or too complex to encode manually,…

Machine Learning · Computer Science 2021-05-11 Alexander Hagg , Sebastian Berns , Alexander Asteroth , Simon Colton , Thomas Bäck

Material discovery is a critical research area with profound implications for various industries. In this work, we introduce MatExpert, a novel framework that leverages Large Language Models (LLMs) and contrastive learning to accelerate the…

Materials Science · Physics 2024-10-30 Qianggang Ding , Santiago Miret , Bang Liu

"How to evaluate the de novo designs proposed by a generative model?" Despite the transformative potential of generative deep learning in drug discovery, this seemingly simple question has no clear answer. The absence of standardized…

Biomolecules · Quantitative Biology 2025-11-14 Rıza Özçelik , Francesca Grisoni

Molecular property prediction and generative design via deep learning models has been the subject of intense research given its potential to accelerate development of new, high-performance materials. More recently, these workflows have been…

Artificial Intelligence · Computer Science 2024-12-16 Nathaniel H. Park , Tiffany J. Callahan , James L. Hedrick , Tim Erdmann , Sara Capponi

Significant advancements have been made in one of the most critical branches of artificial intelligence: natural language processing (NLP). These advancements are exemplified by the remarkable success of OpenAI's GPT-3.5/4 and the recent…

Materials Science · Physics 2025-04-22 Zongrui Pei , Junqi Yin , Jiaxin Zhang

New technology for energy storage is necessary for the large-scale adoption of renewable energy sources like wind and solar. The ability to discover suitable catalysts is crucial for making energy storage more cost-effective and scalable.…

Chemical Physics · Physics 2024-04-17 Patrick Geitner

Generating novel and useful concepts is essential during the early design stage to explore a large variety of design opportunities, which usually requires advanced design thinking ability and a wide range of knowledge from designers.…

Computation and Language · Computer Science 2022-11-08 Qihao Zhu , Jianxi Luo

Generative AI poses both opportunities and risks for solving inverse design problems in the sciences. Generative tools provide the ability to expand and refine a search space autonomously, but do so at the cost of exploring low-quality…

Machine Learning · Computer Science 2025-10-01 Marcus Schwarting , Logan Ward , Nathaniel Hudson , Xiaoli Yan , Ben Blaiszik , Santanu Chaudhuri , Eliu Huerta , Ian Foster

As several industries are moving towards modeling massive 3D virtual worlds, the need for content creation tools that can scale in terms of the quantity, quality, and diversity of 3D content is becoming evident. In our work, we aim to train…

Computer Vision and Pattern Recognition · Computer Science 2022-09-23 Jun Gao , Tianchang Shen , Zian Wang , Wenzheng Chen , Kangxue Yin , Daiqing Li , Or Litany , Zan Gojcic , Sanja Fidler

The main drawback of using generative AI models for advanced mathematics is that these models are not primarily logical reasoning engines. However, Large Language Models, and their refinements, can pick up on patterns in higher mathematics…

History and Overview · Mathematics 2025-12-19 Lisa Carbone

Autoregressive transformers have revolutionized generative models in language processing and shown substantial promise in image and video generation. However, these models face significant challenges when extended to 3D generation tasks due…

Computer Vision and Pattern Recognition · Computer Science 2024-09-11 Jinzhi Zhang , Feng Xiong , Mu Xu

Novel concepts are essential for design innovation and can be generated with the aid of data stimuli and computers. However, current generative design algorithms focus on diagrammatic or spatial concepts that are either too abstract to…

Computation and Language · Computer Science 2021-11-17 Qihao Zhu , Jianxi Luo