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Diffusion MRI (dMRI) provides a distinctive means to probe the microstructural architecture of living tissue, facilitating applications such as brain connectivity analysis, modeling across multiple conditions, and the estimation of…

Image and Video Processing · Electrical Eng. & Systems 2025-11-20 Jongyeon Yoon , Elyssa M. McMaster , Michael E. Kim , Gaurav Rudravaram , Kurt G. Schilling , Bennett A. Landman , Daniel Moyer

Diffusion Magnetic Resonance Imaging (MRI) exploits the anisotropic diffusion of water molecules in the brain to enable the estimation of the brain's anatomical fiber tracts at a relatively high resolution. In particular, tractographic…

Computational Engineering, Finance, and Science · Computer Science 2016-09-14 Yu Jin , Joseph F. JaJa , Rong Chen , Edward H. Herskovits

White matter tract segmentation is crucial for studying brain structural connectivity and neurosurgical planning. However, segmentation remains challenging due to issues like class imbalance between major and minor tracts, structural…

Computer Vision and Pattern Recognition · Computer Science 2025-01-28 Anoushkrit Goel , Bipanjit Singh , Ankita Joshi , Ranjeet Ranjan Jha , Chirag Ahuja , Aditya Nigam , Arnav Bhavsar

Streamline classification is essential to identify anatomically meaningful white matter tracts from diffusion MRI (dMRI) tractography. However, current streamline classification methods rely primarily on the geometric features of the…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Haotian Yan , Bocheng Guo , Jianzhong He , Nir A. Sochen , Ofer Pasternak , Lauren J O'Donnell , Fan Zhang

Fiber tractography is an important tool of computational neuroscience that enables reconstructing the spatial connectivity and organization of white matter of the brain. Fiber tractography takes advantage of diffusion Magnetic Resonance…

Image and Video Processing · Electrical Eng. & Systems 2020-09-08 Tomer Weiss , Sanketh Vedula , Ortal Senouf , Oleg Michailovich , AlexBronstein

We propose a novel and efficient algorithm to model high-level topological structures of neuronal fibers. Tractography constructs complex neuronal fibers in three dimensions that exhibit the geometry of white matter pathways in the brain.…

Computer Vision and Pattern Recognition · Computer Science 2021-08-04 S. Shailja , Angela Zhang , B. S. Manjunath

The segregation of brain fiber tractography data into distinct and anatomically meaningful clusters can help to comprehend the complex brain structure and early investigation and management of various neural disorders. We propose a novel…

Computer Vision and Pattern Recognition · Computer Science 2017-10-17 Tushar Gupta , Shreyas Malakarjun Patil , Mukkaram Tailor , Daksh Thapar , Aditya Nigam

Purpose: In diffusion MRI (dMRI), the volumetric and bundle analyses of whole-brain tissue microstructure and connectivity can be severely impeded by an incomplete field-of-view (FOV). This work aims to develop a method for imputing the…

Tractograms are virtual representations of the white matter fibers of the brain. They are of primary interest for tasks like presurgical planning, and investigation of neuroplasticity or brain disorders. Each tractogram is composed of…

Neurons and Cognition · Quantitative Biology 2020-07-10 Pietro Astolfi , Ruben Verhagen , Laurent Petit , Emanuele Olivetti , Jonathan Masci , Davide Boscaini , Paolo Avesani

Diffusion Tensor Imaging (DTI) is an effective tool for the analysis of structural brain connectivity in normal development and in a broad range of brain disorders. However efforts to derive inherent characteristics of structural brain…

Computational Engineering, Finance, and Science · Computer Science 2018-02-14 Yu Jin , Joseph F. JaJa , Rong Chen , Edward H. Herskovits

Diffusion-weighted magnetic resonance imaging (dMRI) allows non-invasive investigation of whole-brain connectivity, which can potentially help to reveal the brain's global network architecture and abnormalities involved in neurological and…

Vision Transformer (ViT) is a pioneering deep learning framework that can address real-world computer vision issues, such as image classification and object recognition. Importantly, ViTs are proven to outperform traditional deep learning…

Computer Vision and Pattern Recognition · Computer Science 2023-03-07 Yuda Bi , Anees Abrol , Zening Fu , Vince Calhoun

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial strategy for white matter (WM) parcellation. Current methods primarily use the geometric information of fibers (i.e., the spatial trajectories) to group similar fibers…

Image and Video Processing · Electrical Eng. & Systems 2024-12-17 Jin Wang , Bocheng Guo , Yijie Li , Junyi Wang , Yuqian Chen , Jarrett Rushmore , Nikos Makris , Yogesh Rathi , Lauren J O'Donnell , Fan Zhang

Tractography traces the peak directions extracted from fiber orientation distribution (FOD) suffering from ambiguous spatial correspondences between diffusion directions and fiber geometry, which is prone to producing erroneous tracks while…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Yuanjing Feng , Lei Xie , Jingqiang Wang , Qiyuan Tian , Jianzhong He , Qingrun Zeng , Fei Gao

Shape plays an important role in computer graphics, offering informative features to convey an object's morphology and functionality. Shape analysis in brain imaging can help interpret structural and functionality correlations of the human…

Computer Vision and Pattern Recognition · Computer Science 2025-04-23 Yui Lo , Yuqian Chen , Dongnan Liu , Wan Liu , Leo Zekelman , Fan Zhang , Yogesh Rathi , Nikos Makris , Alexandra J. Golby , Weidong Cai , Lauren J. O'Donnell

Deep learning approaches for diffusion MRI have so far focused primarily on voxel-based segmentation of lesions or white-matter fiber tracts. A drawback of representing tracts as volumetric labels, rather than sets of streamlines, is that…

Image and Video Processing · Electrical Eng. & Systems 2020-09-10 Christian Ewert , David Kügler , Anastasia Yendiki , Martin Reuter

Fiber tracking based on diffusion weighted Magnetic Resonance Imaging (dMRI) allows for noninvasive reconstruction of fiber bundles in the human brain. In this chapter, we discuss sources of error and uncertainty in this technique, and…

Computer Vision and Pattern Recognition · Computer Science 2013-07-15 Thomas Schultz , Anna Vilanova , Ralph Brecheisen , Gordon Kindlmann

In the present work, we use information theory to understand the empirical convergence rate of tractography, a widely-used approach to reconstruct anatomical fiber pathways in the living brain. Based on diffusion MRI data, tractography is…

Quantitative Methods · Quantitative Biology 2018-06-13 Daniel Moyer , Paul M. Thompson , Greg Ver Steeg

Diffusion MRI tractography is an important tool for identifying and analyzing the intracranial course of cranial nerves (CNs). However, the complex environment of the skull base leads to ambiguous spatial correspondence between diffusion…

Image and Video Processing · Electrical Eng. & Systems 2024-09-23 Lei Xie , Qingrun Zeng , Huajun Zhou , Guoqiang Xie , Mingchu Li , Jiahao Huang , Jianan Cui , Hao Chen , Yuanjing Feng

Traumatic brain injury (TBI) disrupts thalamocortical connectivity, contributing to cognitive impairment and post-traumatic epilepsy (PTE). This study presents a novel tractography-based framework that leverages diffusion maps to capture…

Quantitative Methods · Quantitative Biology 2025-10-21 Akul Sharma , Anand A. Joshi , Richard M. Leahy