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Coronary artery bypass grafts (CABG) surgery is an invasive procedure performed to circumvent partial or complete blood flow blockage in coronary artery disease (CAD). In this work, we apply a numerical optimal flow control model to…

Numerical Analysis · Mathematics 2023-08-08 Zakia Zainib , Francesco Ballarin , Stephen Fremes , Piero Triverio , Laura Jiménez-Juan , Gianluigi Rozza

This paper presents a projection-based reduced order modelling (ROM) framework for unsteady parametrized optimal control problems (OCP$_{(\mu)}$s) arising from cardiovascular (CV) applications. In real-life scenarios, accurately defining…

In this work the development of a machine learning-based Reduced Order Model (ROM) for the investigation of hemodynamics in a patient-specific configuration of Coronary Artery Bypass Graft (CABG) is proposed. The computational domain is…

Medical Physics · Physics 2023-08-08 Pierfrancesco Siena , Michele Girfoglio , Francesco Ballarin , Gianluigi Rozza

We introduce reduced order methods as an efficient strategy to solve parametrized non-linear and time dependent optimal flow control problems governed by partial differential equations. Indeed, the optimal control problems require a huge…

Numerical Analysis · Mathematics 2023-08-08 Maria Strazzullo , Zakia Zainib , Francesco Ballarin , Gianluigi Rozza

We are interested in a reduced order method for the efficient simulation of blood flow in arteries. The blood dynamics is modeled by means of the incompressible Navier-Stokes equations. Our algorithm is based on an approximated…

Numerical Analysis · Mathematics 2021-04-07 Luca Pegolotti , Martin Pfaller , Alison Marsden , Simone Deparis

Reduced-order models based on physics are a popular choice in cardiovascular modeling due to their efficiency, but they may experience reduced accuracy when working with anatomies that contain numerous junctions or pathological conditions.…

Cardiovascular diseases are a leading cause of death in the world, driving the development of patient-specific and benchmark models for blood flow analysis. This chapter provides a theoretical overview of the main categories of Reduced…

Numerical Analysis · Mathematics 2025-10-21 Pierfrancesco Siena , Pasquale Claudio Africa , Michele Girfoglio , Gianluigi Rozza

In this contribution we propose reduced order methods to fast and reliably solve parametrized optimal control problems governed by time dependent nonlinear partial differential equations. Our goal is to provide a tool to deal with the time…

Numerical Analysis · Mathematics 2023-08-08 Francesco Ballarin , Gianluigi Rozza , Maria Strazzullo

A data-driven Reduced Order Model (ROM) based on a Proper Orthogonal Decomposition - Radial Basis Function (POD-RBF) approach is adopted in this paper for the analysis of blood flow dynamics in a patient-specific case of Atrial Fibrillation…

In this work we present a Reduced Order Model which is specifically designed to deal with turbulent flows in a finite volume setting. The method used to build the reduced order model is based on the idea of merging/combining…

Numerical Analysis · Mathematics 2025-12-04 Saddam Hijazi , Giovanni Stabile , Andrea Mola , Gianluigi Rozza

Parametric reduced-order modelling often serves as a surrogate method for hemodynamics simulations to improve the computational efficiency in many-query scenarios or to perform real-time simulations. However, the snapshots of the method…

Computational Engineering, Finance, and Science · Computer Science 2023-10-24 Dongwei Ye , Valeria Krzhizhanovskaya , Alfons G. Hoekstra

Predictive modeling of blood flow and pressure have numerous applications ranging from non-invasive assessment of functional significance of disease to planning invasive procedures. While several such predictive modeling techniques have…

This paper deals with the development of a Reduced-Order Model (ROM) to investigate haemodynamics in cardiovascular applications. It employs the use of Proper Orthogonal Decomposition (POD) for the computation of the basis functions and the…

Numerical Analysis · Mathematics 2025-01-24 Pierfrancesco Siena , Pasquale Claudio Africa , Michele Girfoglio , Gianluigi Rozza

The present focus of heart flow studies is largely based on flow within the left ventricle and how this flow changes when subject to disease. However, despite recent advancements, a simple tractable model of even healthy left ventricular…

Fluid Dynamics · Physics 2019-03-18 Giuseppe Di Labbio , Lyes Kadem

A Finite-Volume based POD-Galerkin reduced order modeling strategy for steady-state Reynolds averaged Navier--Stokes (RANS) simulation is extended for low-Prandtl number flow. The reduced order model is based on a full order model for which…

Fluid Dynamics · Physics 2020-08-04 Kelbij Star , Giovanni Stabile , Gianluigi Rozza , Joris Degroote

Computational fluid dynamics (CFD) simulations play an important role in engineering science and applications, however, it is not applicable for problems requiring a large number of repeated calculations. Accordingly, many reduced-order…

Fluid Dynamics · Physics 2026-05-28 Shan Ding , Yongfu Tian , Rui Yang

We present a comparative computational study of two stabilized Reduced Order Models (ROMs) for the simulation of convection-dominated incompressible flow (Reynolds number of the order of a few thousands). Representative solutions in the…

Fluid Dynamics · Physics 2024-05-01 Pierfrancesco Siena , Michele Girfoglio , Annalisa Quaini , Gianluigi Rozza

We present a novel numerical algorithm developed to reconstuct pulsatile blood flow from ECG-gated CT angiography data. A block-based optimization method was constructed to solve the inverse problem corresponding to the Riccati-type…

Numerical Analysis · Mathematics 2015-11-26 Attila Lovas , Róbert Nagy , Elek Csobo , Brigitta Szilágyi , Péter Sótonyi

In this work we propose reduced order methods as a reliable strategy to efficiently solve parametrized optimal control problems governed by shallow waters equations in a solution tracking setting. The physical parametrized model we deal…

Numerical Analysis · Mathematics 2023-08-08 Maria Strazzullo , Francesco Ballarin , Gianluigi Rozza

Accurate and efficient modeling of cardiac blood flow is crucial for advancing data-driven tools in cardiovascular research and clinical applications. Recently, the accuracy and availability of computational fluid dynamics (CFD)…

Fluid Dynamics · Physics 2025-07-30 Eneko Lazpita , Jesus Garicano-Mena , Soledad Le Clainche
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