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Generative diffusion models have achieved spectacular performance in many areas of machine learning and generative modeling. While the fundamental ideas behind these models come from non-equilibrium physics, variational inference and…

Machine Learning · Statistics 2024-06-21 Luca Ambrogioni

We examine a spatially discrete reaction diffusion model based on the interactions that create a periodic pattern in the Drosophila eye imaginal disc. This model is capable of generating a regular hexagonal pattern of gene expression behind…

Molecular Networks · Quantitative Biology 2010-01-26 Matthew W. Pennington , David K. Lubensky

Pattern formation mechanisms of a reaction-diffusion-advection system, with one diffusivity, differential advection, and (Robin) boundary conditions of Danckwerts type, are being studied. Pattern selection requires mapping the domains of…

Pattern Formation and Solitons · Physics 2009-11-23 Arik Yochelis , Moshe Sheintuch

Gene expression patterns (GEPs) are established by cross-regulating target genes that interpret morphogen gradients. However, as development progresses, morphogen activity is reduced, leaving the emergent GEP without stabilizing positional…

Biological Physics · Physics 2025-02-04 Maciej Majka , Nils B. Becker , Pieter Rein ten Wolde , Marcin Zagorski , Thomas R. Sokolowski

Precise temporal coordination of gene expression is crucial for many developmental processes. One central question in developmental biology is how such coordinated expression patterns are robustly controlled. During embryonic development of…

Molecular Networks · Quantitative Biology 2015-05-14 Akihiko Nakajima , Takako Isshiki , Kunihiko Kaneko , Shuji Ishihara

This study investigates transient wave dynamics in Turing pattern formation, focusing on waves emerging from localised disturbances. While the traditional focus of diffusion-driven instability has primarily centred on stationary solutions,…

Pattern Formation and Solitons · Physics 2024-03-15 Václav Klika , Eamonn A. Gaffney , Philip K. Maini

In his seminal paper on morphogenesis (1952), Alan Turing demonstrated that different spatio-temporal patterns can arise due to instability of the homogeneous state in reaction-diffusion systems, but at least two species are necessary to…

Formal Languages and Automata Theory · Computer Science 2014-06-03 Yuri Shalygo

Nonequilibrium conditions fundamentally change how systems undergo phase separation. In systems with temperature gradients, attractive particles have been shown to form periodic patterns and steady convective currents, but a clear…

Statistical Mechanics · Physics 2026-03-09 Meander Van den Brande , François Huveneers , Kyosuke Adachi

Consistency models have been proposed for fast generative modeling, achieving results competitive with diffusion and flow models. However, these methods exhibit inherent instability and limited reproducibility when training from scratch,…

Machine Learning · Computer Science 2026-02-02 Youngjoong Kim , Duhoe Kim , Woosung Kim , Jaesik Park

Mathematical models of stem cell differentiation are commonly based upon the concept of subsequent cell fate decisions, each controlled by a gene regulatory network. These networks exhibit a multistable behavior and cause the system to…

Quantitative Methods · Quantitative Biology 2011-07-06 Christian Breindl , Daniella Schittler , Steffen Waldherr , Frank Allgöwer

This paper investigates the mathematical modeling and the stability of multi-lane traffic in the microscopic scale, studying a model based on two interaction terms. To do this we propose simple lane changing conditions and we study the…

Classical Analysis and ODEs · Mathematics 2023-12-05 Matteo Piu , Gabriella Puppo

Stochastic dynamics of chemical reactions in a mutually repressing two-gene circuit is numerically simulated. The circuit has a rich variety of different states when the kinetic change of DNA status is slow. The stochastic switching…

Disordered Systems and Neural Networks · Physics 2009-11-11 Tomohiro Ushikubo , Wataru Inoue , Mitsumasa Yoda , Masaki Sasai

Multistable gene regulatory systems sustain different levels of gene expression under identical external conditions. Such multistability is used to encode phenotypic states in processes including nutrient uptake and persistence in bacteria,…

Molecular Networks · Quantitative Biology 2014-12-05 Prasanna M. Bhogale , Robin A. Sorg , Jan-Willem Veening , Johannes Berg

We study pattern formation in a chemotaxis model of bacteria and soil carbon dynamics as an example system where transient dynamics can give rise to pattern formation outside of Turing unstable regimes. We use a detailed analysis of the…

Genes are connected in complex networks of interactions where often the product of one gene is a transcription factor that alters the expression of another. Many of these networks are based on a few fundamental motifs leading to switches…

Molecular Networks · Quantitative Biology 2026-03-05 Zitao Yang , Rebecca J. Rousseau , Sara D. Mahdavi , Hernan G. Garcia , Rob Phillips

From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times. The decision when to express a gene is implemented by the binding and unbinding…

Molecular Networks · Quantitative Biology 2009-11-13 Johannes Berg

The formation of self-organized patterns is key to the morphogenesis of multicellular organisms, although a comprehensive theory of biological pattern formation is still lacking. Here, we propose a minimal model combining tissue mechanics…

Biological Physics · Physics 2022-06-08 P. Recho , A. Hallou , E. Hannezo

In this work, the influence of geometry and domain size on spatiotemporal pattern formation is investigated to establish parameter spaces for a cross-diffusive reaction-diffusion model on an annulus. By applying linear stability theory, we…

Dynamical Systems · Mathematics 2024-12-31 Gulsemay Yigit , Wakil Sarfaraz , Raquel Barreira , Anotida Madzvamuse

This paper proposes a control theoretic framework to model and analyze the self-organized pattern formation of molecular concentrations in biomolecular communication networks, emerging applications in synthetic biology. In biomolecular…

Molecular Networks · Quantitative Biology 2019-01-08 Yutaka Hori , Hiroki Miyazako , Soichiro Kumagai , Shinji Hara

We propose a new non-equilibrium model for spatial pattern formation on the basis of local information transfer. Unlike standard models of pattern formation it is not based on the Turing instability. Information is transmitted through the…

Statistical Mechanics · Physics 2007-05-23 Thimo Rohlf , Stefan Bornholdt
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