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Biological fitness is not an observable quantity and must be inferred from population dynamics. Bayesian inference applied to the Moran process and variants yields a robust inference method that can infer fitness in populations evolving via…

Dynamical Systems · Mathematics 2013-10-24 Marc Harper

We consider a stochastic individual-based model of adaptive dynamics for an asexually reproducing population with mutation, with linear birth and death rates, as well as a density-dependent competition. To depict repeating changes of the…

Populations and Evolution · Quantitative Biology 2025-05-28 Manuel Esser , Anna Kraut

Phenotypically structured equations arise in population biology to describe the interaction of species with their environment that brings the nutrients. This interaction usually leads to selection of the fittest individuals. Models used in…

Analysis of PDEs · Mathematics 2015-06-18 Alexander Lorz , Benoit Perthame

The adaptive evolution of large asexual populations is generally characterized by competition between clones carrying different beneficial mutations. This interference phenomenon slows down the adaptation speed and makes the theoretical…

Populations and Evolution · Quantitative Biology 2012-12-20 Maria Rita Fumagalli , Matteo Osella , Philippe Thomen , Francois Heslot , Marco Cosentino Lagomarsino

Many mathematical models of evolution assume that all individuals experience the same environment. Here, we study the Moran process in heterogeneous environments. The population is of finite size with two competing types, which are exposed…

Populations and Evolution · Quantitative Biology 2018-12-19 Kamran Kaveh , Alex McAvoy , Martin A. Nowak

We are living in an uncertain and dynamically changing world, where optimal decision-making under uncertainty is directly linked to the survival of species. However, evolutionary selection pressures that shape value-based decision-making…

Populations and Evolution · Quantitative Biology 2018-04-04 Erdem Pulcu

We present a mathematical simplification for the evolutionary dynamics of a heritable trait within a two-sex population. This trait is assumed to control the timing of sex-specific life-history events, such as the age of sexual maturity and…

Populations and Evolution · Quantitative Biology 2019-07-04 M. H. Chan , K. Hawkes , P. S. Kim

We consider the evolution of an asexually reproducing population in an uncorrelated random fitness landscape in the limit of infinite genome size, which implies that each mutation generates a new fitness value drawn from a probability…

Populations and Evolution · Quantitative Biology 2009-11-13 Su-Chan Park , Joachim Krug

On rugged fitness landscapes where sign epistasis is common, adaptation can often involve either individually beneficial "uphill" mutations or more complex mutational trajectories involving fitness valleys or plateaus. The dynamics of the…

Populations and Evolution · Quantitative Biology 2015-10-06 Ian E. Ochs , Michael M. Desai

We analyze the long-term stability of a stochastic model designed to illustrate the adaptation of a population to variation in its environment. A piecewise-deterministic process modeling adaptation is coupled to a Feller logistic diffusion…

Probability · Mathematics 2021-09-14 Aurélien Velleret

In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can…

Populations and Evolution · Quantitative Biology 2013-12-19 D. B. Weissman , O. Hallatschek

We study the evolution of recombination using a microscopic model developed within the frame of the theory of quantitative traits. Two components of fitness are considered: a static one that describes adaptation to environmental factors not…

Populations and Evolution · Quantitative Biology 2007-05-23 Franco Bagnoli , Carlo Guardiani

Since steep declines in a population's size also typically alter its composition, population bottlenecks are considered highly important for evolution. However, despite such significance, the mechanisms governing the impact of a given…

Populations and Evolution · Quantitative Biology 2022-06-28 Emanuele Crosato , Jeffrey N. Philippson , Shashi Thutupalli , Richard G. Morris

Intraspecific trait variation has been increasingly recognized as an important factor in determining species interaction and diversity. Eco-evolutionary models have studied the distribution of trait values within a population that changes…

Populations and Evolution · Quantitative Biology 2023-10-12 Zachary Jackson , BingKan Xue

We consider a stochastic individual-based model of adaptive dynamics for an asexually reproducing population with mutation. Biologically motivated by the influence of seasons or the variation of drug concentration during medical treatment,…

Probability · Mathematics 2025-03-26 Manuel Esser , Anna Kraut

In this review some simple models of asexual populations evolving on smooth landscapes are studied. The basic model is based on a cellular automaton, which is analyzed here in the spatial mean-field limit. Firstly, the evolution on a fixed…

Statistical Mechanics · Physics 2016-11-23 Franco Bagnoli , Michele Bezzi

Phenotypes of individuals in a population of organisms are not fixed. Phenotypic fluctuations, which describe temporal variation of the phenotype of an individual or individual-to-individual variation across a population, are present in…

Populations and Evolution · Quantitative Biology 2018-08-15 Hong-Yan Shih , Harry Mickalide , David T. Fraebel , Nigel Goldenfeld , Seppe Kuehn

We consider evolution of a large population, where fitness of each organism is defined by many phenotypical traits. These traits result from expression of many genes. We propose a new model of gene regulation, where gene expression is…

Populations and Evolution · Quantitative Biology 2016-09-29 John Reinitz , Sergey Vakulenko , Dmitri Grigoriev , Andreas Weber

We study the dynamics of a population subject to selective pressures, evolving either on RNA neutral networks or in toy fitness landscapes. We discuss the spread and the neutrality of the population in the steady state. Different limits…

Populations and Evolution · Quantitative Biology 2009-11-13 Sumedha , Olivier C Martin , Luca Peliti

Consider a mathematical model of evolutionary adaptation of fitness landscape and mutation matrix as a reaction to population changes. As a basis, we use an open quasispecies model, which is modified to include explicit death flow. We…

Populations and Evolution · Quantitative Biology 2020-11-25 Igor Samokhin , Tatiana Yakushkina , Alexander S. Bratus
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