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Timely and accurate assessment of cognitive impairment remains a major unmet need. Speech biomarkers offer a scalable, non-invasive, cost-effective solution for automated screening. However, the clinical utility of machine learning (ML)…

Alzheimer's disease (AD) is a growing global health challenge as populations age, and timely, accurate diagnosis is essential to reduce individual and societal burden. However, real-world AD assessment is hampered by incomplete,…

To better model the contextual information and increase the generalization ability of Speech Activity Detection (SAD) system, this paper leverages a multi-lingual Automatic Speech Recognition (ASR) system to perform SAD. Sequence…

Sound · Computer Science 2021-04-13 Seyyed Saeed Sarfjoo , Srikanth Madikeri , Petr Motlicek

Can ChatGPT diagnose Alzheimer's Disease (AD)? AD is a devastating neurodegenerative condition that affects approximately 1 in 9 individuals aged 65 and older, profoundly impairing memory and cognitive function. This paper utilises 9300…

Machine Learning · Computer Science 2025-02-12 Quoc-Toan Nguyen , Linh Le , Xuan-The Tran , Thomas Do , Chin-Teng Lin

Previous researchers have proposed intelligent systems for therapeutic monitoring of cognitive impairments. However, most existing practical approaches for this purpose are based on manual tests. This raises issues such as excessive…

Whisper fails to correctly transcribe dementia speech because persons with dementia (PwDs) often exhibit irregular speech patterns and disfluencies such as pauses, repetitions, and fragmented sentences. It was trained on standard speech and…

Audio and Speech Processing · Electrical Eng. & Systems 2025-05-29 Emmanuel Akinrintoyo , Nadine Abdelhalim , Nicole Salomons

Speaker adaptation techniques provide a powerful solution to customise automatic speech recognition (ASR) systems for individual users. Practical application of unsupervised model-based speaker adaptation techniques to data intensive…

Audio and Speech Processing · Electrical Eng. & Systems 2023-02-16 Jiajun Deng , Xurong Xie , Tianzi Wang , Mingyu Cui , Boyang Xue , Zengrui Jin , Guinan Li , Shujie Hu , Xunying Liu

Early diagnosis of Alzheimer's Disease (AD), particularly at the mild cognitive impairment stage, is essential for timely intervention. However, this process faces significant barriers, including reliance on subjective assessments and the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Changwei Wu , Yifei Chen , Yuxin Du , Jinying Zong , Jie Dong , Mingxuan Liu , Feiwei Qin , Yong Peng , Jin Fan , Changmiao Wang

Cognitive impairment detection through spontaneous speech is a promising avenue for early diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI), where timely intervention can significantly improve patient outcomes. The…

Sound · Computer Science 2025-02-19 Yifan Gao , Long Guo , Hong Liu

Recently Transformer and Convolution neural network (CNN) based models have shown promising results in Automatic Speech Recognition (ASR), outperforming Recurrent neural networks (RNNs). Transformer models are good at capturing…

Audio and Speech Processing · Electrical Eng. & Systems 2020-05-19 Anmol Gulati , James Qin , Chung-Cheng Chiu , Niki Parmar , Yu Zhang , Jiahui Yu , Wei Han , Shibo Wang , Zhengdong Zhang , Yonghui Wu , Ruoming Pang

Accurate diagnosis of Alzheimer's Disease (AD) entails clinical evaluation of multiple cognition metrics and biomarkers. Metrics such as the Alzheimer's Disease Assessment Scale - Cognitive test (ADAS-cog) comprise multiple subscores that…

Machine Learning · Statistics 2017-08-16 Lev E. Givon , Laura J. Mariano , David O'Dowd , John M. Irvine , Abraham R. Schneider

Introduction: It is challenging at baseline to predict when and which individuals who meet criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer's disease (AD) dementia. Methods: A deep learning method is…

Computer Vision and Pattern Recognition · Computer Science 2019-04-17 Hongming Li , Mohamad Habes , David A. Wolk , Yong Fan

For effective treatment of Alzheimer disease (AD), it is important to identify subjects who are most likely to exhibit rapid cognitive decline. Herein, we developed a novel framework based on a deep convolutional neural network which can…

Computer Vision and Pattern Recognition · Computer Science 2017-04-21 Hongyoon Choi , Kyong Hwan Jin

Dementia is a syndrome characterised by the decline of different cognitive abilities. Alzheimer's Disease (AD) is the most common dementia affecting cognitive domains such as memory and learning, perceptual-motion or executive function.…

Computer Vision and Pattern Recognition · Computer Science 2018-10-26 Juan Manuel Fernández Montenegro

Despite major advancements in Automatic Speech Recognition (ASR), the state-of-the-art ASR systems struggle to deal with impaired speech even with high-resource languages. In Arabic, this challenge gets amplified, with added complexities in…

Sound · Computer Science 2023-06-08 Massa Baali , Ibrahim Almakky , Shady Shehata , Fakhri Karray

Alzheimer's Disease (AD) is a severe brain disorder, destroying memories and brain functions. AD causes chronically, progressively, and irreversibly cognitive declination and brain damages. The reliable and effective evaluation of early…

Image and Video Processing · Electrical Eng. & Systems 2021-01-07 Kuo Yang , Emad A. Mohammed

End-to-end Automatic Speech Recognition (ASR) systems based on neural networks have seen large improvements in recent years. The availability of large scale hand-labeled datasets and sufficient computing resources made it possible to train…

Computer Vision and Pattern Recognition · Computer Science 2023-01-05 Maxime Burchi , Radu Timofte

Objective: This paper presents an Alzheimer's disease (AD) detection method based on learning structural similarity between Magnetic Resonance Images (MRIs) and representing this similarity as a graph. Methods: We construct the similarity…

Computer Vision and Pattern Recognition · Computer Science 2021-03-01 Kuo Yang , Emad A. Mohammed , Behrouz H. Far

We present two multimodal fusion-based deep learning models that consume ASR transcribed speech and acoustic data simultaneously to classify whether a speaker in a structured diagnostic task has Alzheimer's Disease and to what degree,…

Computation and Language · Computer Science 2021-07-01 Morteza Rohanian , Julian Hough , Matthew Purver

Alzheimer's disease (AD) has become a prevalent neurodegenerative disease worldwide. Traditional diagnosis still relies heavily on medical imaging and clinical assessment by physicians, which is often time-consuming and resource-intensive…

Computation and Language · Computer Science 2026-02-17 Tongze Zhang , Jun-En Ding , Melik Ozolcer , Fang-Ming Hung , Albert Chih-Chieh Yang , Feng Liu , Yi-Rou Ji , Sang Won Bae