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Background: Alignment of biological sequences such as DNA, RNA or proteins is one of the most widely used tools in computational bioscience. All existing alignment algorithms rely on heuristic scoring schemes based on biological expertise.…

Genomics · Quantitative Biology 2008-10-27 Orion Penner , Peter Grassberger , Maya Paczuski

For safety assurance of deep neural networks (DNNs), out-of-distribution (OoD) monitoring techniques are essential as they filter spurious input that is distant from the training dataset. This paper studies the problem of systematically…

Software Engineering · Computer Science 2022-05-17 Chih-Hong Cheng , Changshun Wu , Emmanouil Seferis , Saddek Bensalem

Instruction tuning (IT) achieves impressive zero-shot generalization results by training large language models (LLMs) on a massive amount of diverse tasks with instructions. However, how to select new tasks to improve the performance and…

Computation and Language · Computer Science 2023-11-02 Po-Nien Kung , Fan Yin , Di Wu , Kai-Wei Chang , Nanyun Peng

A new trend in deep learning, represented by Mutual Information Neural Estimation (MINE) and Information Noise Contrast Estimation (InfoNCE), is emerging. In this trend, similarity functions and Estimated Mutual Information (EMI) are used…

Information Theory · Computer Science 2023-05-25 Chenguang Lu

Deep Neural Networks (DNNs) are increasingly utilized in high-stakes domains like medical diagnostics and autonomous driving where model reliability is critical. However, the research landscape for ensuring this reliability is…

Machine Learning · Computer Science 2026-04-07 Ole Delzer , Sidney Bender

Meta-learning optimizes an inductive bias---typically in the form of the hyperparameters of a base-learning algorithm---by observing data from a finite number of related tasks. This paper presents an information-theoretic bound on the…

Machine Learning · Computer Science 2021-02-09 Arezou Rezazadeh , Sharu Theresa Jose , Giuseppe Durisi , Osvaldo Simeone

The use of Mutual Information (MI) as a measure to evaluate the efficiency of cryptosystems has an extensive history. However, estimating MI between unknown random variables in a high-dimensional space is challenging. Recent advances in…

Safe reinforcement learning has traditionally relied on predefined constraint functions to ensure safety in complex real-world tasks, such as autonomous driving. However, defining these functions accurately for varied tasks is a persistent…

Machine Learning · Computer Science 2025-01-31 Se-Wook Yoo , Seung-Woo Seo

As reinforcement learning techniques are increasingly applied to real-world decision problems, attention has turned to how these algorithms use potentially sensitive information. We consider the task of training a policy that maximizes…

Machine Learning · Computer Science 2024-04-17 Chris Cundy , Rishi Desai , Stefano Ermon

In the last decade, recent successes in deep clustering majorly involved the Mutual Information (MI) as an unsupervised objective for training neural networks with increasing regularisations. While the quality of the regularisations have…

AI applications are becoming increasingly visible to the general public. There is a notable gap between the theoretical assumptions researchers make about computer vision models and the reality those models face when deployed in the real…

Computer Vision and Pattern Recognition · Computer Science 2023-12-05 Eashan Adhikarla , Kai Zhang , Jun Yu , Lichao Sun , John Nicholson , Brian D. Davison

Machine learning models tend to over-rely on statistical shortcuts. These spurious correlations between parts of the input and the output labels does not hold in real-world settings. We target this issue on the recent open-ended visual…

Computer Vision and Pattern Recognition · Computer Science 2020-07-02 Corentin Dancette , Remi Cadene , Xinlei Chen , Matthieu Cord

Deep neural networks have attained remarkable performance when applied to data that comes from the same distribution as that of the training set, but can significantly degrade otherwise. Therefore, detecting whether an example is…

Computer Vision and Pattern Recognition · Computer Science 2020-04-02 Yen-Chang Hsu , Yilin Shen , Hongxia Jin , Zsolt Kira

Despite outperforming the human in many tasks, deep neural network models are also criticized for the lack of transparency and interpretability in decision making. The opaqueness results in uncertainty and low confidence when deploying such…

Machine Learning · Computer Science 2017-09-14 Huijun Wu , Chen Wang , Jie Yin , Kai Lu , Liming Zhu

Medical imaging cohorts are often confounded by factors such as acquisition devices, hospital sites, patient backgrounds, and many more. As a result, deep learning models tend to learn spurious correlations instead of causally related…

Computer Vision and Pattern Recognition · Computer Science 2024-07-30 Sarah Müller , Louisa Fay , Lisa M. Koch , Sergios Gatidis , Thomas Küstner , Philipp Berens

Inferring connectivity in neuronal networks remains a key challenge in statistical neuroscience. The `common input' problem presents the major roadblock: it is difficult to reliably distinguish causal connections between pairs of observed…

Neurons and Cognition · Quantitative Biology 2014-12-19 Daniel Soudry , Suraj Keshri , Patrick Stinson , Min-hwan Oh , Garud Iyengar , Liam Paninski

Measurement-induced entanglement (MIE) captures how local measurements generate long-range quantum correlations and drive dynamical phase transitions in many-body systems. Yet estimating MIE experimentally remains challenging: direct…

Quantum Physics · Physics 2025-12-11 Dongheng Qian , Jing Wang

Neural networks are known to exploit spurious artifacts (or shortcuts) that co-occur with a target label, exhibiting heuristic memorization. On the other hand, networks have been shown to memorize training examples, resulting in…

Machine Learning · Computer Science 2024-02-05 Rachit Bansal , Danish Pruthi , Yonatan Belinkov

Cross-modality data translation has attracted great interest in image computing. Deep generative models (\textit{e.g.}, GANs) show performance improvement in tackling those problems. Nevertheless, as a fundamental challenge in image…

Computer Vision and Pattern Recognition · Computer Science 2023-02-01 Zihao Wang , Yingyu Yang , Maxime Sermesant , Hervé Delingette , Ona Wu

In the analysis of time series from nonlinear sources, mutual information (MI) is used as a nonlinear statistical criterion for the selection of an appropriate time delay in time delay reconstruction of the state space. MI is a statistic…

Chaotic Dynamics · Physics 2009-10-31 Henry D. I. Abarbanel , Naoki Masuda , M. I. Rabinovich , Evren Tumer