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The accurate prediction of changes in protein stability under multiple amino acid substitutions is essential for realising true in-silico protein re-design. To this purpose, we propose improvements to state-of-the-art Deep learning (DL)…

Biomolecules · Quantitative Biology 2023-06-01 Sebastien Boyer , Sam Money-Kyrle , Oliver Bent

We present a new algorithm to learn a deep neural network model robust against adversarial attacks. Previous algorithms demonstrate an adversarially trained Bayesian Neural Network (BNN) provides improved robustness. We recognize the…

Machine Learning · Computer Science 2023-12-04 Bao Gia Doan , Ehsan Abbasnejad , Javen Qinfeng Shi , Damith C. Ranasinghe

Reconstructing complex 3D interfaces from indirect measurements remains a grand challenge in scientific computing, particularly for ill-posed inverse problems like Electrical Impedance Tomography (EIT). Traditional shape optimization…

Numerical Analysis · Mathematics 2026-04-23 Haibo Liu , Junqing Chen , Guang Lin

The unfolding of detector effects is crucial for the comparison of data to theory predictions. While traditional methods are limited to representing the data in a low number of dimensions, machine learning has enabled new unfolding…

High Energy Physics - Phenomenology · Physics 2024-01-12 Mathias Backes , Anja Butter , Monica Dunford , Bogdan Malaescu

Graph convolutional neural networks (GCNNs) have emerged as powerful tools for analyzing graph-structured data, achieving remarkable success across diverse applications. However, the theoretical understanding of the stability of these…

Machine Learning · Computer Science 2025-10-28 Ning Zhang , Henry Kenlay , Li Zhang , Mihai Cucuringu , Xiaowen Dong

Stress prediction in porous materials and structures is challenging due to the high computational cost associated with direct numerical simulations. Convolutional Neural Network (CNN) based architectures have recently been proposed as…

Computational Engineering, Finance, and Science · Computer Science 2023-11-07 Vasilis Krokos , Stéphane P. A. Bordas , Pierre Kerfriden

Modern deep neural networks are well known to be brittle in the face of unknown data instances and recognition of the latter remains a challenge. Although it is inevitable for continual-learning systems to encounter such unseen concepts,…

Machine Learning · Computer Science 2022-04-04 Martin Mundt , Iuliia Pliushch , Sagnik Majumder , Yongwon Hong , Visvanathan Ramesh

Neural generative models can be used to learn complex probability distributions from data, to sample from them, and to produce probability density estimates. We propose a computational framework for developing neural generative models…

Machine Learning · Computer Science 2022-01-06 Alexander Ororbia , Daniel Kifer

This paper introduces Graph Convolutional Recurrent Network (GCRN), a deep learning model able to predict structured sequences of data. Precisely, GCRN is a generalization of classical recurrent neural networks (RNN) to data structured by…

Machine Learning · Statistics 2016-12-23 Youngjoo Seo , Michaël Defferrard , Pierre Vandergheynst , Xavier Bresson

This paper presents a probabilistic framework to obtain both reliable and fast uncertainty estimates for predictions with Deep Neural Networks (DNNs). Our main contribution is a practical and principled combination of DNNs with sparse…

Robotics · Computer Science 2021-09-22 Jongseok Lee , Jianxiang Feng , Matthias Humt , Marcus G. Müller , Rudolph Triebel

Spatio-temporal dynamics of physical processes are generally modeled using partial differential equations (PDEs). Though the core dynamics follows some principles of physics, real-world physical processes are often driven by unknown…

Machine Learning · Computer Science 2021-09-01 Priyabrata Saha , Saurabh Dash , Saibal Mukhopadhyay

A simple, flexible approach to creating expressive priors in Gaussian process (GP) models makes new kernels from a combination of basic kernels, e.g. summing a periodic and linear kernel can capture seasonal variation with a long term…

Machine Learning · Statistics 2019-07-01 Tim Pearce , Russell Tsuchida , Mohamed Zaki , Alexandra Brintrup , Andy Neely

Deep Neural Networks (DNNs) have become increasingly popular in computer vision, natural language processing, and other areas. However, training and fine-tuning a deep learning model is computationally intensive and time-consuming. We…

Machine Learning · Computer Science 2018-07-04 Jiayi Liu , Samarth Tripathi , Unmesh Kurup , Mohak Shah

Deep Generative Networks (DGNs) with probabilistic modeling of their output and latent space are currently trained via Variational Autoencoders (VAEs). In the absence of a known analytical form for the posterior and likelihood expectation,…

Machine Learning · Computer Science 2020-06-18 Randall Balestriero , Sebastien Paris , Richard G. Baraniuk

Modern deep neural networks (DNNs) are typically trained with a global cross-entropy loss in a supervised end-to-end manner: neurons need to store their outgoing weights; training alternates between a forward pass (computation) and a…

Machine Learning · Computer Science 2025-11-03 Shuyan Lyu , Zhanzimo Wu , Junliang Du

Recurrent neural networks (RNNs) are particularly well-suited for modeling long-term dependencies in sequential data, but are notoriously hard to train because the error backpropagated in time either vanishes or explodes at an exponential…

Machine Learning · Computer Science 2019-08-28 Anil Kag , Ziming Zhang , Venkatesh Saligrama

Physics-informed neural networks (PINNs) have lately received significant attention as a representative deep learning-based technique for solving partial differential equations (PDEs). Most fully connected network-based PINNs use automatic…

Machine Learning · Computer Science 2024-09-30 Zixue Xiang , Wei Peng , Wen Yao

Node representation learning by using Graph Neural Networks (GNNs) has been widely explored. However, in recent years, compelling evidence has revealed that GNN-based node representation learning can be substantially deteriorated by…

Machine Learning · Computer Science 2023-12-19 Jun Zhuang , Mohammad Al Hasan

Causal discovery from observational data is challenging, especially with large datasets and complex relationships. Traditional methods often struggle with scalability and capturing global structural information. To overcome these…

Machine Learning · Computer Science 2025-07-29 Rezaur Rashid , Gabriel Terejanu

We develop a new method for regularising neural networks. We learn a probability distribution over the activations of all layers of the model and then insert imputed values into the network during training. We obtain a posterior for an…

Machine Learning · Computer Science 2019-10-14 Matthew Willetts , Alexander Camuto , Stephen Roberts , Chris Holmes