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AlphaFold has achieved groundbreaking advancements in protein structure prediction, exerting profound influence across biology, medicine, and drug discovery. However, its reliance on multiple sequence alignment (MSA) is inherently…

Quantum Physics · Physics 2025-06-03 Rong Chen , Quan-Xin Mei , Wen-Ding Zhao , Lin Yao , Hao-Xiang Yang , Shun-Yao Zhang , Jiao Chen , Hong-Lin Li

The computation of quantum entanglement can be formulated as a high-dimensional nonconvex optimization problem with orthogonality constraints. In this work, we propose structure-preserving consensus-based optimization (CBO) methods for…

Quantum Physics · Physics 2026-05-12 Michael Herty , Yijia Tang , Yizhou Zhou

Due to the linearity of quantum mechanics, it remains a challenge to design quantum generative machine learning models that embed non-linear activations into the evolution of the statevector. However, some of the most successful classical…

Quantum Physics · Physics 2023-01-18 Kaitlin Gili , Mykolas Sveistrys , Chris Ballance

Quantum computers leverage the unique advantages of quantum mechanics to achieve acceleration over classical computers for certain problems. Currently, various quantum simulators provide powerful tools for researchers, but simulating…

Quantum Physics · Physics 2024-10-31 Shuangxiang Zhou , Ronghang Chen , Zheng An , Shi-Yao Hou

Quantum machine learning is emerging as a promising application of quantum computing due to its distinct way of encoding and processing data. It is believed that large-scale quantum machine learning demonstrates substantial advantages over…

Quantum Physics · Physics 2025-01-15 Kiwmann Hwang , Hyang-Tag Lim , Yong-Su Kim , Daniel K. Park , Yosep Kim

The optimal phase covariant cloning machine (PQCM) broadcasts the information associated to an input qubit into a multi-qubit systems, exploiting a partial a-priori knowledge of the input state. This additional a priori information leads to…

Quantum Physics · Physics 2009-11-13 Fabio Sciarrino , Francesco De Martini

We propose and analyze a versatile and efficient multiparameter quantum sensing protocol, which simultaneously estimates many non-commuting and time-dependent signals that are coherently or incoherently coupled to sensing particles. Even in…

Quantum Physics · Physics 2026-02-02 Wenjie Gong , Bingtian Ye , Daniel Mark , Soonwon Choi

Distributed quantum computation is often proposed to increase the scalability of quantum hardware, as it reduces cooperative noise and requisite connectivity by sharing quantum information between distant quantum devices. However, such…

Quantum Physics · Physics 2023-09-13 Abigail McClain Gomez , Taylor L. Patti , Anima Anandkumar , Susanne F. Yelin

Recent work on the instantaneous quantum polynomial-time (IQP) quantum-circuit Born machine (QCBM) highlights a promising paradigm for generative modeling: train classically, deploy quantumly. In this setting, the training objective can be…

This paper presents the first application of Gaussian Mixture Copula Models to the statistical modeling of driving scenarios for the safety validation of automated driving systems. Knowledge of the joint probability distribution of scenario…

Robotics · Computer Science 2026-01-27 Christian Reichenbächer , Philipp Rank , Jochen Hipp , Oliver Bringmann

We study a classical model for the accumulation of errors in multi-qubit quantum computations. By modeling the error process in a quantum computation using two coupled Markov chains, we are able to capture a weak form of time-dependency…

Quantum Physics · Physics 2021-04-26 Long Ma , Jaron Sanders

Quantum computers hold promise to enable efficient simulations of the properties of molecules and materials; however, at present they only permit ab initio calculations of a few atoms, due to a limited number of qubits. In order to harness…

Materials Science · Physics 2020-07-07 He Ma , Marco Govoni , Giulia Galli

A unitary coupled-cluster (UCC) form for the wavefunction in the variational quantum eigensolver has been suggested as a systematic way to go beyond the mean-field approximation and include electron correlation in solving quantum chemistry…

Quantum Physics · Physics 2018-09-12 Ilya G. Ryabinkin , Tzu-Ching Yen , Scott N. Genin , Artur F. Izmaylov

Copula-based modeling has seen rapid advances in recent years. However, in big data applications, the lengthy computation time for estimating copula parameters is a major difficulty. Here, we develop a novel method to speed computation time…

Methodology · Statistics 2016-09-20 Zheng Wei , Daeyoung Kim , Erin Marie Conlon

Recent advancements have highlighted the limitations of current quantum systems, particularly the restricted number of qubits available on near-term quantum devices. This constraint greatly inhibits the range of applications that can…

Quantum computing is an emerging technology, promising a paradigm shift in computing, and allowing for speedups in many different problems. However, quantum devices are still in their early stages, most with only a small number qubits. This…

Quantum Physics · Physics 2018-11-09 Adam Kelly

Simulating the quantum dynamics of molecules in the condensed phase represents a longstanding challenge in chemistry. Trapped-ion quantum systems may serve as a platform for the analog-quantum simulation of chemical dynamics that is beyond…

Quantum dynamics compilation is an important task for improving quantum simulation efficiency: It aims to synthesize multi-qubit target dynamics into a circuit consisting of as few elementary gates as possible. Compared to deterministic…

Quantum Physics · Physics 2024-09-26 Yuxuan Zhang , Roeland Wiersema , Juan Carrasquilla , Lukasz Cincio , Yong Baek Kim

Future wired and wireless communication systems will employ pure or combined Code Division Multiple Access (CDMA) technique, such as in the European 3G mobile UMTS or Power Line Telecommunication system, but also several 4G proposal…

Quantum Physics · Physics 2016-11-18 Sandor Imre , Ferenc Balazs

We present hierarchical learning, a novel variational architecture for efficient training of large-scale variational quantum circuits. We test and benchmark our technique for distribution loading with quantum circuit born machines (QCBMs).…

Quantum Physics · Physics 2023-11-23 Hrant Gharibyan , Vincent Su , Hayk Tepanyan
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