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Annotating automatic target recognition (ATR) is a highly challenging task, primarily due to the unavailability of labeled data in the target domain. Hence, it is essential to construct an optimal target domain classifier by utilizing the…

Computer Vision and Pattern Recognition · Computer Science 2024-11-22 Shoaib Meraj Sami , Md Mahedi Hasan , Nasser M. Nasrabadi , Raghuveer Rao

Designing full-length, epitope-specific TCR {\alpha}\b{eta} remains challenging due to vast sequence space, data biases and incomplete modeling of immunogenetic constraints. We present LSMTCR, a scalable multi-architecture framework that…

Computational Engineering, Finance, and Science · Computer Science 2025-10-09 Ruihao Zhang , Xiao Liu

T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors (TCRs) on their surface to short peptides (p) derived from foreign proteins, which are…

Biological Physics · Physics 2016-06-22 Andrej Kosmrlj , Arup K. Chakraborty , Mehran Kardar , Eugene I. Shakhnovich

Drug-target interaction (DTI) prediction is crucial for drug development and repositioning. Methods using heterogeneous graph neural networks (HGNNs) for DTI prediction have become a promising approach, with attention-based models often…

Biomolecules · Quantitative Biology 2024-11-05 Junwei Hu , Michael Bewong , Selasi Kwashie , Wen Zhang , Vincent M. Nofong , Guangsheng Wu , Zaiwen Feng

Early detection of cancers has been much explored due to its paramount importance in biomedical fields. Among different types of data used to answer this biological question, studies based on T cell receptors (TCRs) are under recent…

Machine Learning · Statistics 2022-08-10 Younghoon Kim , Tao Wang , Danyi Xiong , Xinlei Wang , Seongoh Park

Hypervariable T-cell receptors (TCR) play a key role in adaptive immunity, recognising a vast diversity of pathogen-derived antigens. High throughput sequencing of TCR repertoires (RepSeq) produces huge datasets of T-cell receptor sequences…

We introduce the Temporal Contrastive Transformer (TCT), a representation learning framework designed to capture contextual temporal dynamics in sequences of financial transactions. The model is trained using a self-supervised contrastive…

Machine Learning · Computer Science 2026-05-22 Danny Butvinik , Yonit Marcus , Nitzan Tal , Gabrielle Azoulay

In protein biophysics, the separation between the functionally important residues (forming the active site or binding surface) and those that create the overall structure (the fold) is a well-established and fundamental concept. Identifying…

Biomolecules · Quantitative Biology 2023-10-17 Tianxiao Li , Hongyu Guo , Filippo Grazioli , Mark Gerstein , Martin Renqiang Min

This study introduces the Multi-Scale Weight-Based Pairwise Coarsening and Contrastive Learning (MPCCL) model, a novel approach for attributed graph clustering that effectively bridges critical gaps in existing methods, including long-range…

Machine Learning · Computer Science 2025-07-29 Binxiong Li , Yuefei Wang , Binyu Zhao , Heyang Gao , Benhan Yang , Quanzhou Luo , Xue Li , Xu Xiang , Yujie Liu , Huijie Tang

Motivated by the success of coarse-grained or fine-grained contrast in text-video retrieval, there emerge multi-grained contrastive learning methods which focus on the integration of contrasts with different granularity. However, due to the…

Information Retrieval · Computer Science 2025-04-08 Xiaolun Jing , Genke Yang , Jian Chu

Hierarchical classification is a crucial task in many applications, where objects are organized into multiple levels of categories. However, conventional classification approaches often neglect inherent inter-class relationships at…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Julius Ott , Nastassia Vysotskaya , Huawei Sun , Lorenzo Servadei , Robert Wille

In medical time series disease diagnosis, two key challenges are identified. First, the high annotation cost of medical data leads to overfitting in models trained on label-limited, single-center datasets. To address this, we propose…

Human-Computer Interaction · Computer Science 2025-08-08 Yifan Wang , Hongfeng Ai , Ruiqi Li , Maowei Jiang , Ruiyuan Kang , Jiahua Dong , Cheng Jiang , Chenzhong Li

Drug-target binding affinity prediction plays an important role in the early stages of drug discovery, which can infer the strength of interactions between new drugs and new targets. However, the performance of previous computational models…

Machine Learning · Computer Science 2023-07-19 Xinxing Yang , Genke Yang , Jian Chu

Reliable detection of anomalies is crucial when deploying machine learning models in practice, but remains challenging due to the lack of labeled data. To tackle this challenge, contrastive learning approaches are becoming increasingly…

Computer Vision and Pattern Recognition · Computer Science 2021-07-19 Puck de Haan , Sindy Löwe

Vision Transformer (ViT) has shown its advantages over the convolutional neural network (CNN) with its ability to capture global long-range dependencies for visual representation learning. Besides ViT, contrastive learning is another…

Computer Vision and Pattern Recognition · Computer Science 2022-07-12 Hua-Bao Ling , Bowen Zhu , Dong Huang , Ding-Hua Chen , Chang-Dong Wang , Jian-Huang Lai

Contrastive learning has moved the state of the art for many tasks in computer vision and information retrieval in recent years. This poster is the first work that applies supervised contrastive learning to the task of product matching in…

Machine Learning · Computer Science 2022-05-03 Ralph Peeters , Christian Bizer

Alongside neuroimaging such as MRI scans and PET, Alzheimer's disease (AD) datasets contain valuable tabular data including AD biomarkers and clinical assessments. Existing computer vision approaches struggle to utilize this additional…

Computer Vision and Pattern Recognition · Computer Science 2023-08-30 Weichen Huang

Knowledge tracing (KT) refers to the problem of predicting future learner performance given their past performance in educational applications. Recent developments in KT using flexible deep neural network-based models excel at this task.…

Machine Learning · Computer Science 2020-07-27 Aritra Ghosh , Neil Heffernan , Andrew S. Lan

In recent years, self-supervised representation learning for skeleton-based action recognition has been developed with the advance of contrastive learning methods. The existing contrastive learning methods use normal augmentations to…

Computer Vision and Pattern Recognition · Computer Science 2021-12-08 Tianyu Guo , Hong Liu , Zhan Chen , Mengyuan Liu , Tao Wang , Runwei Ding

Contrastive representation learning is crucial in time series analysis as it alleviates the issue of data noise and incompleteness as well as sparsity of supervision signal. However, existing constrastive learning frameworks usually focus…

Machine Learning · Computer Science 2024-06-26 Haozhi Gao , Qianqian Ren , Jinbao Li