Related papers: Stability versus Meta-stability in a Skin Microbio…
Disease psoriasis occurs as chronic inflammation of skin and appears as scaly red lesions on skin surface. Advent of several immunosuppressive drugs established that the disease stems from immuno-pathogenic disorder in human blood. Cell…
Bacteriophages are viruses infecting bacteria and archaea. Many phage species cause infections which lead to the certain death of the infected prokaryotic host cell and the release of a large batch of phage progeny, yet they have been able…
A multiphasic constitutive model of the skin that implicitly accounts for the process of intrinsic (i.e.\ chronological) ageing via variation of the constitutive parameters is proposed. The structurally-motivated constitutive formulation…
[abridged] Background: The distribution of chemical species in an open system at metastable equilibrium can be expressed as a function of environmental variables which can include temperature, oxidation-reduction potential and others.…
Skin and soft tissue infections (SSTIs) are among the most frequently observed diseases in ambulatory and hospital settings. Resistance of diverse bacterial pathogens to antibiotics is a significant cause of severe SSTIs, and treatment…
The evolution of various competing cell types in tissues, and the resulting persistent tissue population, is studied numerically and analytically in a particle-based model of active tissues. Mutations change the properties of cells in…
Skin is one of the largest human organ systems whose primary purpose is the protection of deeper tissues. As such, the skin must maintain a homeostatic balance in the face of many microenvironmental and genetic perturbations. At its…
We present a two-species population model in a well-mixed environment where the dynamics involves, in addition to birth and death, changes due to environmental factors and inter-species interactions. The novel dynamical components are…
Personalized models of the gut microbiome are valuable for disease prevention and treatment. For this, one requires a mathematical model that predicts microbial community composition and the emergent behavior of microbial communities. We…
A review of recent investigations into pathogenesis of psoriasis summarizing data on the relationship between the presence beta-streptococci in the organism and the cutaneous immune reaction. Results of the studies on gastrointestinal…
Microbiome-based stratification of healthy individuals into compositional categories, referred to as "community types", holds promise for drastically improving personalized medicine. Despite this potential, the existence of community types…
Maintenance of epidermal thickness is critical to the barrier function of the skin. Decreased tissue thickness, specifically in the stratum corneum (the outermost layer of the tissue), causes discomfort and inflammation, and is related to…
Atherosclerosis is a chronic inflammatory disease occurs due to plaque accumulation in the inner artery wall. In atherosclerotic plaque formation monocytes and macrophages play a significant role in controlling the disease dynamics. In the…
Microbial communities are ubiquitous in nature and come in a multitude of forms, ranging from communities dominated by a handful of species to communities containing a wide variety of metabolically distinct organisms. This huge range in…
Mathematical models for physiological processes aid qualitative understanding of the impact of various parameters on the underlying process. We analyse two such models for human physiological processes: the Mackey-Glass and the Lasota…
The contribution to an organism's phenotype from one genetic locus may depend upon the status of other loci. Such epistatic interactions among loci are now recognized as fundamental to shaping the process of adaptation in evolving…
Stochastic phenotype switching has been suggested to play a beneficial role in microbial populations by leading to the division of labour among cells, or ensuring that at least some of the population survives an unexpected change in…
Many studies have been performed to characterize the dynamics and stability of the microbiome across a range of environmental contexts [Costello et al., 2012, Faust et al., 2015]. For example, it is often of interest to identify time…
The existence of phenotypic heterogeneity in single-species bacterial biofilms is well-established in the published literature. However, the modeling of population dynamics in biofilms from the viewpoint of social interactions, i.e.…
A deterministic nonlinear ordinary differential equation model for mosquito dynamics in which the mosquitoes can quest for blood either within a human population or within non-human/vertebrate populations is derived and studied. The model…