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Histopathological images contain rich phenotypic information that can be used to monitor underlying mechanisms contributing to diseases progression and patient survival outcomes. Recently, deep learning has become the mainstream…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Chetan L. Srinidhi , Ozan Ciga , Anne L. Martel

Whole slide imaging is fundamental to biomedical microscopy and computational pathology. Previously, learning representations for gigapixel-sized whole slide images (WSIs) has relied on multiple instance learning with weak labels, which do…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Xinhai Hou , Cheng Jiang , Akhil Kondepudi , Yiwei Lyu , Asadur Chowdury , Honglak Lee , Todd C. Hollon

Accurate diagnosis of breast cancer in histopathology images is challenging due to the heterogeneity of cancer cell growth as well as of a variety of benign breast tissue proliferative lesions. In this paper, we propose a practical and…

Computer Vision and Pattern Recognition · Computer Science 2020-05-06 Xingyu Li , Marko Radulovic , Ksenija Kanjer , Konstantinos N. Plataniotis

Recent advancements in Digital Pathology (DP), particularly through artificial intelligence and Foundation Models, have underscored the importance of large-scale, diverse, and richly annotated datasets. Despite their critical role, publicly…

Image and Video Processing · Electrical Eng. & Systems 2025-05-20 Dmitry Nechaev , Alexey Pchelnikov , Ekaterina Ivanova

Cancer detection and classification from gigapixel whole slide images of stained tissue specimens has recently experienced enormous progress in computational histopathology. The limitation of available pixel-wise annotated scans shifted the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-30 Mehdi Naouar , Gabriel Kalweit , Ignacio Mastroleo , Philipp Poxleitner , Marc Metzger , Joschka Boedecker , Maria Kalweit

Skin lesion analysis models are biased by artifacts placed during image acquisition, which influence model predictions despite carrying no clinical information. Solutions that address this problem by regularizing models to prevent learning…

Computer Vision and Pattern Recognition · Computer Science 2023-08-11 Alceu Bissoto , Catarina Barata , Eduardo Valle , Sandra Avila

Automation in medical imaging is quite challenging due to the unavailability of annotated datasets and the scarcity of domain experts. In recent years, deep learning techniques have solved some complex medical imaging tasks like disease…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Soumyajyoti Dey , Sukanta Chakraborty , Utso Guha Roy , Nibaran Das

Multiple instance (MI) learning with a convolutional neural network enables end-to-end training in the presence of weak image-level labels. We propose a new method for aggregating predictions from smaller regions of the image into an…

Computer Vision and Pattern Recognition · Computer Science 2018-06-14 Heather D. Couture , J. S. Marron , Charles M. Perou , Melissa A. Troester , Marc Niethammer

Accurate identification of breast cancer types plays a critical role in guiding treatment decisions and improving patient outcomes. This paper presents an artificial intelligence enabled tool designed to aid in the identification of breast…

Image and Video Processing · Electrical Eng. & Systems 2025-05-28 Neil Chaudhary , Zaynah Dhunny

Pathological captioning of Whole Slide Images (WSIs), though is essential in computer-aided pathological diagnosis, has rarely been studied due to the limitations in datasets and model training efficacy. In this paper, we propose a new…

Computer Vision and Pattern Recognition · Computer Science 2023-11-01 Wenkang Qin , Rui Xu , Peixiang Huang , Xiaomin Wu , Heyu Zhang , Lin Luo

An optical microscopic examination of thinly cut stained tissue on glass slides prepared from a FFPE tissue blocks is the gold standard for tissue diagnostics. In addition, the diagnostic abilities and expertise of any pathologist is…

Semantic segmentation of breast cancer metastases in histopathological slides is a challenging task. In fact, significant variation in data characteristics of histopathology images (domain shift) make generalization of deep learning to…

Image and Video Processing · Electrical Eng. & Systems 2021-06-01 Gianluca Gerard , Marco Piastra

Computational analysis of whole slide images (WSIs) has seen significant research progress in recent years, with applications ranging across important diagnostic and prognostic tasks such as survival or cancer subtype prediction. Many…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Zak Buzzard , Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

Instance segmentation of nuclei and glands in the histology images is an important step in computational pathology workflow for cancer diagnosis, treatment planning and survival analysis. With the advent of modern hardware, the recent…

Image and Video Processing · Electrical Eng. & Systems 2022-12-27 Esha Sadia Nasir , Arshi Perviaz , Muhammad Moazam Fraz

Histopathological characterization of colorectal polyps is an important principle for determining the risk of colorectal cancer and future rates of surveillance for patients. This characterization is time-intensive, requires years of…

Computer Vision and Pattern Recognition · Computer Science 2017-04-14 Bruno Korbar , Andrea M. Olofson , Allen P. Miraflor , Katherine M. Nicka , Matthew A. Suriawinata , Lorenzo Torresani , Arief A. Suriawinata , Saeed Hassanpour

Histopathologic Images (HI) are the gold standard for evaluation of some tumors. However, the analysis of such images is challenging even for experienced pathologists, resulting in problems of inter and intra observer. Besides that, the…

Computer Vision and Pattern Recognition · Computer Science 2019-04-18 Jonathan de Matos , Alceu de Souza Britto , Luiz E. S. Oliveira , Alessandro L. Koerich

An often overlooked problem in medical image segmentation research is the effective selection of training subsets to annotate from a complete set of unlabelled data. Many studies select their training sets at random, which may lead to…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Stephen Lloyd-Brown , Susan Francis , Caroline Hoad , Penny Gowland , Karen Mullinger , Andrew French , Xin Chen

Deep Neural Networks have shown promising classification performance when predicting certain biomarkers from Whole Slide Images in digital pathology. However, the calibration of the networks' output probabilities is often not evaluated.…

Image and Video Processing · Electrical Eng. & Systems 2023-12-18 Alexander Kurz , Hendrik A. Mehrtens , Tabea-Clara Bucher , Titus J. Brinker

Automatic and accurate Gleason grading of histopathology tissue slides is crucial for prostate cancer diagnosis, treatment, and prognosis. Usually, histopathology tissue slides from different institutions show heterogeneous appearances…

Computer Vision and Pattern Recognition · Computer Science 2018-06-08 Jian Ren , Ilker Hacihaliloglu , Eric A. Singer , David J. Foran , Xin Qi

Open-set face recognition describes a scenario where unknown subjects, unseen during the training stage, appear on test time. Not only it requires methods that accurately identify individuals of interest, but also demands approaches that…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Rafael Henrique Vareto , William Robson Schwartz