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Alzheimer's disease (AD) is a prevalent and debilitating neurodegenerative disorder impacting a large aging population. Detecting AD in all its presymptomatic and symptomatic stages is crucial for early intervention and treatment. An active…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Yasmine Mustafa , Tie Luo

Early diagnosis of Alzheimer's disease and its prodromal stage, also known as mild cognitive impairment (MCI), is critical since some patients with progressive MCI will develop the disease. We propose a multi-stream deep convolutional…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Mona Ashtari-Majlan , Abbas Seifi , Mohammad Mahdi Dehshibi

Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of…

Quantitative Methods · Quantitative Biology 2021-08-31 Sayantan Kumar , Inez Oh , Suzanne Schindler , Albert M Lai , Philip R O Payne , Aditi Gupta

Recent studies have shown that integrating multimodal data fusion techniques for imaging and genetic features is beneficial for the etiological analysis and predictive diagnosis of Alzheimer's disease (AD). However, there are several…

Genomics · Quantitative Biology 2025-06-03 Lina Qin , Cheng Zhu , Chuqi Zhou , Yukun Huang , Jiayi Zhu , Ping Liang , Jinju Wang , Yixing Huang , Cheng Luo , Dezhong Yao , Ying Tan

Alzheimer's Disease (AD) is the most widespread neurodegenerative disease, affecting over 50 million people across the world. While its progression cannot be stopped, early and accurate diagnostic testing can drastically improve quality of…

Machine Learning · Computer Science 2021-01-11 Vishnu Ram Sampathkumar

Brain-related diseases are more sensitive than other diseases due to several factors, including the complexity of surgical procedures, high costs, and other challenges. Alzheimer's disease is a common brain disorder that causes memory loss…

Image and Video Processing · Electrical Eng. & Systems 2024-03-11 Maleka Khatun , Md Manowarul Islam , Habibur Rahman Rifat , Md. Shamim Bin Shahid , Md. Alamin Talukder , Md Ashraf Uddin

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with increasing prevalence among the aging population, necessitating early and accurate diagnosis for effective disease management. In this study, we present a novel…

Image and Video Processing · Electrical Eng. & Systems 2024-10-04 Romoke Grace Akindele , Samuel Adebayo , Paul Shekonya Kanda , Ming Yu

Multimodal neuroimage can provide complementary information about the dementia, but small size of complete multimodal data limits the ability in representation learning. Moreover, the data distribution inconsistency from different…

Computer Vision and Pattern Recognition · Computer Science 2021-07-22 Qiankun Zuo , Baiying Lei , Yanyan Shen , Yong Liu , Zhiguang Feng , Shuqiang Wang

Alzheimer's disease (AD), characterized by progressive cognitive decline and memory loss, presents a formidable global health challenge, underscoring the critical importance of early and precise diagnosis for timely interventions and…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Arindam Majee , Avisek Gupta , Sourav Raha , Swagatam Das

Introspection of deep supervised predictive models trained on functional and structural brain imaging may uncover novel markers of Alzheimer's disease (AD). However, supervised training is prone to learning from spurious features (shortcut…

Machine Learning · Computer Science 2022-05-24 Alex Fedorov , Lei Wu , Tristan Sylvain , Margaux Luck , Thomas P. DeRamus , Dmitry Bleklov , Sergey M. Plis , Vince D. Calhoun

Alzheimer's disease (AD) progresses from asymptomatic changes to clinical symptoms, emphasizing the importance of early detection for proper treatment. Functional magnetic resonance imaging (fMRI), particularly dynamic functional network…

Computational Engineering, Finance, and Science · Computer Science 2024-08-02 Yuxiang Wei , Anees Abrol , James Lah , Deqiang Qiu , Vince D. Calhoun

Structural magnetic resonance imaging (sMRI) can identify subtle brain changes due to its high contrast for soft tissues and high spatial resolution. It has been widely used in diagnosing neurological brain diseases, such as Alzheimer…

Image and Video Processing · Electrical Eng. & Systems 2023-11-14 Xin Zhang , Liangxiu Han , Lianghao Han , Haoming Chen , Darren Dancey , Daoqiang Zhang

Early diagnosis, playing an important role in preventing progress and treating the Alzheimer's disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related…

Machine Learning · Computer Science 2016-07-05 Ehsan Hosseini-Asl , Georgy Gimel'farb , Ayman El-Baz

Early diagnosis, playing an important role in preventing progress and treating the Alzheimer\{'}s disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related…

Machine Learning · Computer Science 2016-11-15 Ehsan Hosseini-Asl , Robert Keynto , Ayman El-Baz

Neurodegeneration as measured through magnetic resonance imaging (MRI) is recognized as a potential biomarker for diagnosing Alzheimer's disease (AD), but is generally considered less specific than amyloid or tau based biomarkers. Due to a…

Computer Vision and Pattern Recognition · Computer Science 2024-08-06 Rosemary He , Gabriella Ang , Daniel Tward

Accurate diagnosis and prognosis of Alzheimer's disease are crucial to develop new therapies and reduce the associated costs. Recently, with the advances of convolutional neural networks, methods have been proposed to automate these two…

Image and Video Processing · Electrical Eng. & Systems 2022-11-29 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé

Fusing structural-functional images of the brain has shown great potential to analyze the deterioration of Alzheimer's disease (AD). However, it is a big challenge to effectively fuse the correlated and complementary information from…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Qiankun Zuo , Junren Pan , Shuqiang Wang

Deep learning has shown significant potential in diagnosing neurodegenerative diseases from MRI data. However, most existing methods rely heavily on large volumes of labeled data and often yield representations that lack interpretability.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Fangqi Cheng , Yingying Zhao , Xiaochen Yang

Early detection of Alzheimer disease is crucial for deploying interventions and slowing the disease progression. A lot of machine learning and deep learning algorithms have been explored in the past decade with the aim of building an…

Image and Video Processing · Electrical Eng. & Systems 2022-09-26 Narotam Singh , Patteshwari. D , Neha Soni , Amita Kapoor

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, structural brain changes, and genetic predispositions. This study leverages machine-learning and statistical techniques to investigate…

Applications · Statistics 2025-10-29 Riddhik Basu , Arkaprava Roy