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Constructing a robust model that can effectively generalize to test samples under distribution shifts remains a significant challenge in the field of medical imaging. The foundational models for vision and language, pre-trained on extensive…

The recent achievements of Deep Learning rely on the test data being similar in distribution to the training data. In an ideal case, Deep Learning models would achieve Out-of-Distribution (OoD) Generalization, i.e. reliably make predictions…

Image and Video Processing · Electrical Eng. & Systems 2021-09-07 Antoine Sanner , Camila Gonzalez , Anirban Mukhopadhyay

Domain generalisation in computational histopathology is challenging because the images are substantially affected by differences among hospitals due to factors like fixation and staining of tissue and imaging equipment. We hypothesise that…

Image and Video Processing · Electrical Eng. & Systems 2024-11-15 Dhananjay Tomar , Alexander Binder , Andreas Kleppe

Clinical machine learning models show a significant performance drop when tested in settings not seen during training. Domain generalisation models promise to alleviate this problem, however, there is still scepticism about whether they…

Machine Learning · Computer Science 2022-11-14 Dimitris Spathis , Stephanie L. Hyland

Out-of-distribution (OOD) detection is crucial when deploying deep neural networks in the real world to ensure the reliability and safety of their applications. One main challenge in OOD detection is that neural network models often produce…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Jinlun Ye , Zhuohao Sun , Yiqiao Qiu , Qiu Li , Zhijun Tan , Ruixuan Wang

Motivation: Deep learning models deployed for use on medical tasks can be equipped with Out-of-Distribution Detection (OoDD) methods in order to avoid erroneous predictions. However it is unclear which OoDD method should be used in…

Machine Learning · Computer Science 2020-08-06 Tianshi Cao , Chin-Wei Huang , David Yu-Tung Hui , Joseph Paul Cohen

Neural networks are often utilised in critical domain applications (e.g. self-driving cars, financial markets, and aerospace engineering), even though they exhibit overconfident predictions for ambiguous inputs. This deficiency demonstrates…

Machine Learning · Computer Science 2023-01-03 John Mitros , Brian Mac Namee

Deep Learning models are easily disturbed by variations in the input images that were not seen during training, resulting in unpredictable behaviours. Such Out-of-Distribution (OOD) images represent a significant challenge in the context of…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Benjamin Lambert , Florence Forbes , Senan Doyle , Alan Tucholka , Michel Dojat

Out-of-distribution (OOD) generalisation is challenging because it involves not only learning from empirical data, but also deciding among various notions of generalisation, e.g., optimising the average-case risk, worst-case risk, or…

Machine Learning · Computer Science 2024-05-31 Anurag Singh , Siu Lun Chau , Shahine Bouabid , Krikamol Muandet

Out-of-distribution (OOD) generalization remains a fundamental challenge in real-world classification, where test distributions often differ substantially from training data. Most existing approaches pursue domain-invariant representations,…

Machine Learning · Computer Science 2026-01-30 Chen Cheng , Ang Li

Computer-aided diagnostics has benefited from the development of deep learning-based computer vision techniques in these years. Traditional supervised deep learning methods assume that the test sample is drawn from the identical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-04 Zesheng Hong , Yubiao Yue , Yubin Chen , Lele Cong , Huanjie Lin , Yuanmei Luo , Mini Han Wang , Weidong Wang , Jialong Xu , Xiaoqi Yang , Hechang Chen , Zhenzhang Li , Sihong Xie

Deep neural networks have shown promising results in disease detection and classification using medical image data. However, they still suffer from the challenges of handling real-world scenarios especially reliably detecting…

Image and Video Processing · Electrical Eng. & Systems 2021-11-03 Muhammad Zaida , Shafaqat Ali , Mohsen Ali , Sarfaraz Hussein , Asma Saadia , Waqas Sultani

Despite significant advancements, segmentation based on deep neural networks in medical and surgical imaging faces several challenges, two of which we aim to address in this work. First, acquiring complete pixel-level segmentation labels…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Junwen Wang , Zhonghao Wang , Oscar MacCormac , Jonathan Shapey , Tom Vercauteren

Recently, we have witnessed great progress in the field of medical imaging classification by adopting deep neural networks. However, the recent advanced models still require accessing sufficiently large and representative datasets for…

Computer Vision and Pattern Recognition · Computer Science 2020-10-30 Haoliang Li , YuFei Wang , Renjie Wan , Shiqi Wang , Tie-Qiang Li , Alex C. Kot

Generalization to out-of-distribution (OOD) data is a capability natural to humans yet challenging for machines to reproduce. This is because most learning algorithms strongly rely on the i.i.d.~assumption on source/target data, which is…

Machine Learning · Computer Science 2022-08-15 Kaiyang Zhou , Ziwei Liu , Yu Qiao , Tao Xiang , Chen Change Loy

Detecting out-of-distribution (OOD) samples for trusted medical image segmentation remains a significant challenge. The critical issue here is the lack of a strict definition of abnormal data, which often results in artificial problem…

Image and Video Processing · Electrical Eng. & Systems 2023-08-16 Anton Vasiliuk , Daria Frolova , Mikhail Belyaev , Boris Shirokikh

Out-of-Domain (OOD) generalization is the ability of a model trained on one or more domains to generalize to unseen domains. In the ImageNet era of computer vision, evaluation sets for measuring a model's OOD performance were designed to be…

Computer Vision and Pattern Recognition · Computer Science 2025-06-09 Prasanna Mayilvahanan , Roland S. Zimmermann , Thaddäus Wiedemer , Evgenia Rusak , Attila Juhos , Matthias Bethge , Wieland Brendel

Current machine learning methods for medical image analysis primarily focus on developing models tailored for their specific tasks, utilizing data within their target domain. These specialized models tend to be data-hungry and often exhibit…

Image and Video Processing · Electrical Eng. & Systems 2024-07-08 Ece Ozkan , Xavier Boix

Deep Learning systems have achieved great success in the past few years, even surpassing human intelligence in several cases. As of late, they have also established themselves in the biomedical and healthcare domains, where they have shown…

Machine Learning · Computer Science 2022-10-06 Aristotelis Ballas , Christos Diou

Learning robust vision models that perform well in out-of-distribution (OOD) situations is an important task for model deployment in real-world settings. Despite extensive research in this field, many proposed methods have only shown minor…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Gyuseong Lee , Wooseok Jang , Jinhyeon Kim , Jaewoo Jung , Seungryong Kim
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