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Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD,…

Quantitative Methods · Quantitative Biology 2025-01-27 Roberto Goya-Maldonado , Tracy Erwin-Grabner , Ling-Li Zeng , Christopher R. K. Ching , Andre Aleman , Alyssa R. Amod , Zeynep Basgoze , Francesco Benedetti , Bianca Besteher , Katharina Brosch , Robin Bülow , Romain Colle , Colm G. Connolly , Emmanuelle Corruble , Baptiste Couvy-Duchesne , Kathryn Cullen , Udo Dannlowski , Christopher G. Davey , Annemiek Dols , Jan Ernsting , Jennifer W. Evans , Lukas Fisch , Paola Fuentes-Claramonte , Ali Saffet Gonul , Ian H. Gotlib , Hans J. Grabe , Nynke A. Groenewold , Dominik Grotegerd , Tim Hahn , J. Paul Hamilton , Laura K. M. Han , Ben J. Harrison , Tiffany C. Ho , Neda Jahanshad , Alec J. Jamieson , Andriana Karuk , Tilo Kircher , Bonnie Klimes-Dougan , Sheri-Michelle Koopowitz , Thomas Lancaster , Ramona Leenings , Meng Li , David E. J. Linden , Frank P. MacMaster , David M. A. Mehler , Susanne Meinert , Elisa Melloni , Bryon A. Mueller , Benson Mwangi , Igor Nenadić , Amar Ojha , Yasumasa Okamoto , Mardien L. Oudega , Brenda W. J. H. Penninx , Sara Poletti , Edith Pomarol-Clotet , Maria J. Portella , Elena Pozzi , Joaquim Radua , Elena Rodríguez-Cano , Matthew D. Sacchet , Raymond Salvador , Anouk Schrantee , Kang Sim , Jair C. Soares , Aleix Solanes , Dan J. Stein , Frederike Stein , Aleks Stolicyn , Sophia I. Thomopoulos , Yara J. Toenders , Aslihan Uyar-Demir , Eduard Vieta , Yolanda Vives-Gilabert , Henry Völzke , Martin Walter , Heather C. Whalley , Sarah Whittle , Nils Winter , Katharina Wittfeld , Margaret J. Wright , Mon-Ju Wu , Tony T. Yang , Carlos Zarate , Dick J. Veltman , Lianne Schmaal , Paul M. Thompson

We currently observe a disconcerting phenomenon in machine learning studies in psychiatry: While we would expect larger samples to yield better results due to the availability of more data, larger machine learning studies consistently show…

Major depressive disorder is a serious and heterogeneous psychiatric disorder that needs accurate diagnosis. Resting-state functional MRI (rsfMRI), which captures multiple perspectives on brain structure, function, and connectivity, is…

Machine Learning · Computer Science 2023-08-21 Yunsong Luo , Wenyu Chen , Ling Zhan , Jiang Qiu , Tao Jia

Major depressive disorder (MDD) impacts more than 300 million people worldwide, highlighting a significant public health issue. However, the uneven distribution of medical resources and the complexity of diagnostic methods have resulted in…

Computation and Language · Computer Science 2025-05-02 Yuyang Sha , Hongxin Pan , Wei Xu , Weiyu Meng , Gang Luo , Xinyu Du , Xiaobing Zhai , Henry H. Y. Tong , Caijuan Shi , Kefeng Li

Depression has affected millions of people worldwide and has become one of the most common mental disorders. Early mental disorder detection can reduce costs for public health agencies and prevent other major comorbidities. Additionally,…

Computation and Language · Computer Science 2024-04-09 Giuliano Lorenzoni , Cristina Tavares , Nathalia Nascimento , Paulo Alencar , Donald Cowan

Large-scale collaborative analysis of brain imaging data, in psychiatry and neu-rology, offers a new source of statistical power to discover features that boost ac-curacy in disease classification, differential diagnosis, and outcome…

Diagnosis of major depressive disorder (MDD) primarily relies on the patient's self-reported symptoms and a clinical evaluation. Effective connectivity (EC) from resting-state functional magnetic resonance imaging (rs-fMRI) analysis can…

Neurons and Cognition · Quantitative Biology 2024-01-01 Peishan Dai , Yun Shi , Tong Xiong , Xiaoyan Zhou , Shenghui Liao , Zhongchao Huang , Xiaoping Yi , Bihong T. Chen

The global increase in mental illness requires innovative detection methods for early intervention. Social media provides a valuable platform to identify mental illness through user-generated content. This systematic review examines machine…

Machine Learning · Computer Science 2025-02-18 Yuchen Cao , Jianglai Dai , Zhongyan Wang , Yeyubei Zhang , Xiaorui Shen , Yunchong Liu , Yexin Tian

Background Major depressive disorder (MDD) is a leading cause of global disability, yet current diagnostic approaches often rely on subjective assessments and lack the ability to integrate multimodal clinical information. Large language…

Machine Learning · Computer Science 2025-09-30 Yuyang Sha , Hongxin Pan , Gang Luo , Caijuan Shi , Jing Wang , Kefeng Li

Social media platforms provide valuable insights into mental health trends by capturing user-generated discussions on conditions such as depression, anxiety, and suicidal ideation. Machine learning (ML) and deep learning (DL) models have…

Computation and Language · Computer Science 2025-04-28 Zhanyi Ding , Zhongyan Wang , Yeyubei Zhang , Yuchen Cao , Yunchong Liu , Xiaorui Shen , Yexin Tian , Jianglai Dai

Depression has been a leading cause of mental-health illnesses across the world. While the loss of lives due to unmanaged depression is a subject of attention, so is the lack of diagnostic tests and subjectivity involved. Using behavioural…

Artificial Intelligence · Computer Science 2020-10-07 Shivani Shimpi , Shyam Thombre , Snehal Reddy , Ritik Sharma , Srijan Singh

The increasing global prevalence of mental disorders, such as depression and PTSD, requires objective and scalable diagnostic tools. Traditional clinical assessments often face limitations in accessibility, objectivity, and consistency.…

Audio and Speech Processing · Electrical Eng. & Systems 2025-04-03 Abdelrahaman A. Hassan , Abdelrahman A. Ali , Aya E. Fouda , Radwa J. Hanafy , Mohammed E. Fouda

Smartphone sensing offers an unobtrusive and scalable way to track daily behaviors linked to mental health, capturing changes in sleep, mobility, and phone use that often precede symptoms of stress, anxiety, or depression. While most prior…

Machine Learning · Computer Science 2026-01-14 Kaidong Feng , Zhu Sun , Roy Ka-Wei Lee , Xun Jiang , Yin-Leng Theng , Yi Ding

Depression is ranked as the largest contributor to global disability and is also a major reason for suicide. Still, many individuals suffering from forms of depression are not treated for various reasons. Previous studies have shown that…

Computation and Language · Computer Science 2024-10-30 Marcel Trotzek , Sven Koitka , Christoph M. Friedrich

Major depressive disorder (MDD) is a heterogeneous condition; multiple underlying neurobiological substrates could be associated with treatment response variability. Understanding the sources of this variability and predicting outcomes has…

Multimodal machine learning (MML) is rapidly reshaping the way mental-health disorders are detected, characterized, and longitudinally monitored. Whereas early studies relied on isolated data streams -- such as speech, text, or wearable…

Machine Learning · Computer Science 2025-06-25 Zahraa Al Sahili , Ioannis Patras , Matthew Purver

Globally, there is a substantial unmet need to diagnose various diseases effectively. The complexity of the different disease mechanisms and underlying symptoms of the patient population presents massive challenges to developing the early…

Machine Learning · Computer Science 2022-01-03 Md Manjurul Ahsan , Zahed Siddique

Early detection of depression from social media data offers a valuable opportunity for timely intervention. However, this task poses significant challenges, requiring both professional medical knowledge and the development of accurate and…

Computation and Language · Computer Science 2025-03-20 Xiangyong Chen , Xiaochuan Lin

Mental health challenges and cyberbullying are increasingly prevalent in digital spaces, necessitating scalable and interpretable detection systems. This paper introduces a unified multiclass classification framework for detecting ten…

Computation and Language · Computer Science 2026-03-26 Edward Ajayi , Martha Kachweka , Mawuli Deku , Emily Aiken

Emerging evidence showed that major depressive disorder (MDD) is associated with disruptions of brain structural and functional networks, rather than impairment of isolated brain region. Thus, connectome-based models capable of predicting…

Neurons and Cognition · Quantitative Biology 2021-10-18 Aya Kabbara , Gabriel Robert , Mohamad Khalil , Marc Verin , Pascal Benquet , Mahmoud Hassan
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