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Quantifying which neurons are important with respect to the classification decision of a trained neural network is essential for understanding their inner workings. Previous work primarily attributed importance to individual neurons. In…

Machine Learning · Computer Science 2022-11-09 Kenzo Clauw , Sebastiano Stramaglia , Daniele Marinazzo

Higher-order information theory has become a rapidly growing toolkit in computational neuroscience, motivated by the idea that multivariate dependencies can reveal aspects of neural computation and communication that are invisible to…

Neurons and Cognition · Quantitative Biology 2025-12-03 D. Rebbin , K. J. A. Down , T. F. Varley , R. Ince , A. Canales-Johnson

The human brain is a complex system defined by multi-way, higher-order interactions invisible to traditional pairwise network models. Although a diverse array of analytical methods has been developed to address this shortcoming, the field…

Quantitative Methods · Quantitative Biology 2025-11-11 Mohamma Reza Salehi , Ali BashirGonbadi , Hamid Soltanian-Zadeh

Resting-state functional magnetic resonance imaging (fMRI) has emerged as a cornerstone for psychiatric diagnosis, yet most approaches rely on pairwise brain cortical or sub-cortical connectivities that overlooks higher-order interactions…

Machine Learning · Computer Science 2026-04-21 Kunyu Zhang , Qiang Li , Vince D. Calhoun , Shujian Yu

The study of irreducible higher-order interactions has become a core topic of study in complex systems. Two of the most well-developed frameworks, topological data analysis and multivariate information theory, aim to provide formal tools…

Information Theory · Computer Science 2025-04-15 Thomas F. Varley , Pedro A. M. Mediano , Alice Patania , Josh Bongard

The analysis of scientific data and complex multivariate systems requires information quantities that capture relationships among multiple random variables. Recently, new information-theoretic measures have been developed to overcome the…

Machine Learning · Computer Science 2024-06-10 Mustapha Bounoua , Giulio Franzese , Pietro Michiardi

We address the problem of efficiently and informatively quantifying how multiplets of variables carry information about the future of the dynamical system they belong to. In particular we want to identify groups of variables carrying…

Neurons and Cognition · Quantitative Biology 2020-08-03 Sebastiano Stramaglia , Tomas Scagliarini , Bryan C. Daniels , Daniele Marinazzo

O-information is an information-theoretic metric that captures the overall balance between redundant and synergistic information shared by groups of three or more variables. To complement the global assessment provided by this metric, here…

Extracting higher-order structures from multivariate data has become an area of intensive study in complex systems science, as these multipartite interactions can reveal insights into fundamental features of complex systems like emergent…

Information Theory · Computer Science 2026-01-14 Thomas F. Varley

High-order, beyond-pairwise interdependencies are at the core of biological, economic, and social complex systems, and their adequate analysis is paramount to understand, engineer, and control such systems. This paper presents a framework…

Data Analysis, Statistics and Probability · Physics 2022-06-06 Tomas Scagliarini , Daniele Marinazzo , Yike Guo , Sebastiano Stramaglia , Fernando E. Rosas

This article introduces a model-agnostic approach to study statistical synergy, a form of emergence in which patterns at large scales are not traceable from lower scales. Our framework leverages various multivariate extensions of Shannon's…

Information Theory · Computer Science 2019-09-18 Fernando Rosas , Pedro A. M. Mediano , Michael Gastpar , Henrik J. Jensen

The human brain has a complex, intricate functional architecture. While many studies primarily emphasize pairwise interactions, delving into high-order associations is crucial for a comprehensive understanding of how functional brain…

Neurons and Cognition · Quantitative Biology 2023-10-30 Qiang Li , Vince D. Calhoun , Adithya Ram Ballem , Shujian Yu , Jesus Malo , Armin Iraji

Striking progress has recently been made in understanding human cognition by analyzing how its neuronal underpinnings are engaged in different modes of information processing. Specifically, neural information can be decomposed into…

Neurons and Cognition · Quantitative Biology 2022-10-07 Alexandra M. Proca , Fernando E. Rosas , Andrea I. Luppi , Daniel Bor , Matthew Crosby , Pedro A. M. Mediano

Psychiatric disorders have been traditionally conceptualized as latent conditions producing observable symptoms, but recent studies suggest that psychopathology may emerge from symptoms interactions. Psychometric networking model these…

Social and Information Networks · Computer Science 2026-04-27 Francesca Possenti , Laura Girelli , Paolo Tieri , Manuela Petti

Traditional functional connectivity based on functional magnetic resonance imaging (fMRI) can only capture pairwise interactions between brain regions. Hypergraphs, which reveal high-order relationships among multiple brain regions, have…

Neurons and Cognition · Quantitative Biology 2025-05-20 Wenqi Hu , Xuerui Su , Guanliang Li , Yidi Pan , Aijing Lin

A growing interest in complex networks theory results in an ongoing demand for new analytical tools. We propose a novel measure based on information theory that provides a new perspective for a better understanding of networked systems:…

Neurons and Cognition · Quantitative Biology 2019-05-30 Aline Viol , Vesna Vuksanović , Philipp Hövel

The brain is a paradigmatic example of a complex system as its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in…

Neurons and Cognition · Quantitative Biology 2017-01-18 Rossana Mastrandrea , Andrea Gabrielli , Fabrizio Piras , Gianfranco Spalletta , Guido Caldarelli , Tommaso Gili

In the last decade, network science has shed new light both on the structural (anatomical) and on the functional (correlations in the activity) connectivity among the different areas of the human brain. The analysis of brain networks has…

Physics and Society · Physics 2017-04-18 Federico Battiston , Vincenzo Nicosia , Mario Chavez , Vito Latora

The connectome, a map of the structural and/or functional connections in the brain, provides a complex representation of the neurobiological phenotypes on which it supervenes. This information-rich data modality has the potential to…

Multiplex graphs, characterised by their layered structure, exhibit informative interdependencies within layers that are crucial for understanding complex network dynamics. Quantifying the interaction and shared information among these…

Statistics Theory · Mathematics 2024-05-24 Anda Skeja , Sofia C. Olhede
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