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This paper presents an impact assessment for the imputation of missing data. The data set used is HIV Seroprevalence data from an antenatal clinic study survey performed in 2001. Data imputation is performed through five methods: Random…

Methodology · Statistics 2020-11-25 Adam Pantanowitz , Tshilidzi Marwala

Multiple imputation (MI) has become one of the main procedures used to treat missing data, but the guidelines from the methodological literature are not easily transferred to multilevel research. For models including random slopes, proper…

Methodology · Statistics 2016-06-30 Simon Grund , Oliver Lüdtke , Alexander Robitzsch

When outcomes are missing for reasons beyond an investigator's control, there are two different ways to adjust a parameter estimate for covariates that may be related both to the outcome and to missingness. One approach is to model the…

Methodology · Statistics 2008-12-18 Joseph D. Y. Kang , Joseph L. Schafer

During 2020, the infection rate of COVID-19 has been investigated by many scholars from different research fields. In this context, reliable and interpretable forecasts of disease incidents are a vital tool for policymakers to manage…

Machine Learning · Computer Science 2021-01-05 Cornelius Fritz , Emilio Dorigatti , David Rügamer

Missing data theory deals with the statistical methods in the occurrence of missing data. Missing data occurs when some values are not stored or observed for variables of interest. However, most of the statistical theory assumes that data…

The National Health and Nutrition Examination Survey (NHANES) studies the nutritional and health status over the whole U.S. population with comprehensive physical examinations and questionnaires. However, survey data analyses become…

Methodology · Statistics 2019-08-06 Xiaojun Mao , Zhonglei Wang , Shu Yang

Multiple imputation by chained equations (MICE) has emerged as a popular approach for handling missing data. A central challenge for applying MICE is determining how to incorporate outcome information into covariate imputation models,…

Methodology · Statistics 2019-10-11 Lauren Beesley , Jeremy M G Taylor

The case-cohort study design bypasses resource constraints by collecting certain expensive covariates for only a small subset of the full cohort. Weighted Cox regression is the most widely used approach for analysing case-cohort data within…

Methodology · Statistics 2021-09-10 Andrew Yiu , Robert J. B. Goudie , Stephen J. Sharp , Paul J. Newcombe , Brian D. M. Tom

Data from multi-modality provide complementary information in clinical prediction, but missing data in clinical cohorts limits the number of subjects in multi-modal learning context. Multi-modal missing imputation is challenging with…

Image and Video Processing · Electrical Eng. & Systems 2021-07-27 Riqiang Gao , Yucheng Tang , Kaiwen Xu , Ho Hin Lee , Steve Deppen , Kim Sandler , Pierre Massion , Thomas A. Lasko , Yuankai Huo , Bennett A. Landman

Mobile technology (e.g., mobile phones and wearable devices) provides scalable methods for collecting physiological and behavioral biomarkers in patients' naturalistic settings, as well as opportunities for therapeutic advancements and…

Epidemic models are invaluable tools to understand and implement strategies to control the spread of infectious diseases, as well as to inform public health policies and resource allocation. However, current modeling approaches have…

Methodology · Statistics 2026-05-12 Caitlin Ward , Rob Deardon , Alexandra M. Schmidt

Many modern estimators require bootstrapping to calculate confidence intervals because either no analytic standard error is available or the distribution of the parameter of interest is non-symmetric. It remains however unclear how to…

Methodology · Statistics 2018-09-13 Michael Schomaker , Christian Heumann

Many real-world Electronic Health Record (EHR) data contains a large proportion of missing values. Leaving substantial portion of missing information unaddressed usually causes significant bias, which leads to invalid conclusion to be…

Machine Learning · Computer Science 2020-11-04 Lucas J. Liu , Hongwei Zhang , Jianzhong Di , Jin Chen

Can humans impute missing data with similar proficiency as machines? This is the question we aim to answer in this paper. We present a novel idea of converting observations with missing data in to a survey questionnaire, which is presented…

Machine Learning · Computer Science 2018-02-26 Lovedeep Gondara

Electronic health record (EHR)-linked biobank data hold tremendous promise for large-scale discoveries via genome-wide association study (GWAS) on diverse phenotypic traits and biomarkers routinely captured in the EHR. However,…

Applications · Statistics 2026-04-14 Xingran Chen , Cheng-Han Yang , Zhenke Wu , Bhramar Mukherjee

This paper proposes a general multiple imputation approach for analyzing large-scale data with missing values. An imputation model is derived from a joint distribution induced by a latent variable model, which can flexibly capture…

Methodology · Statistics 2025-09-26 Siliang Zhang , Yunxiao Chen , Jouni Kuha

Numerical data imputation algorithms replace missing values by estimates to leverage incomplete data sets. Current imputation methods seek to minimize the error between the unobserved ground truth and the imputed values. But this strategy…

Machine Learning · Statistics 2023-07-11 Florian Lalande , Kenji Doya

Data mining and machine learning techniques such as classification and regression trees (CART) represent a promising alternative to conventional logistic regression for propensity score estimation. Whereas incomplete data preclude the…

Machine Learning · Statistics 2018-07-26 Bas B. L. Penning de Vries , Maarten van Smeden , Rolf H. H. Groenwold

Extracting actionable insight from Electronic Health Records (EHRs) poses several challenges for traditional machine learning approaches. Patients are often missing data relative to each other; the data comes in a variety of modalities,…

Machine Learning · Computer Science 2018-11-13 Brandon Malone , Alberto Garcia-Duran , Mathias Niepert

Clinical trials that investigate interventions on physical activity often use accelerometers to measure step count at a very granular level, often in 5-second epochs. Participants typically wear the accelerometer for a week-long period at…