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In pharmacoepidemiology, safety and effectiveness are frequently evaluated using readily available administrative and electronic health records data. In these settings, detailed confounder data are often not available in all data sources…

Imputing missing values is an important preprocessing step in data analysis, but the literature offers little guidance on how to choose between different imputation models. This letter suggests adopting the imputation model that generates a…

Methodology · Statistics 2021-07-13 Moritz Marbach

Medicine is moving from a curative discipline to a preventative discipline relying on personalised and precise treatment plans. The complex and multi level pathophysiological patterns of most diseases require a systemic medicine approach…

Computational Engineering, Finance, and Science · Computer Science 2020-07-21 Pietro Barbiero , Pietro Lió

Missing data in online reinforcement learning (RL) poses challenges compared to missing data in standard tabular data or in offline policy learning. The need to impute and act at each time step means that imputation cannot be put off until…

Machine Learning · Statistics 2025-10-14 Kyla Chasalow , Skyler Wu , Susan Murphy

National surveys of the healthcare system in the United States were conducted to characterize the structure of healthcare system and investigate the impact of evidence-based innovations in healthcare systems on healthcare services.…

Methodology · Statistics 2023-09-26 Seho Park , Brianna L Hardy , A James OMalley

Inferring causal effects of treatments is a central goal in many disciplines. The potential outcomes framework is a main statistical approach to causal inference, in which a causal effect is defined as a comparison of the potential outcomes…

Methodology · Statistics 2018-01-04 Peng Ding , Fan Li

Electronic health records (EHR) often contain varying levels of missing data. This study compared different imputation strategies to identify the most suitable approach for predicting central line-associated bloodstream infection (CLABSI)…

Multiple imputation provides an effective way to handle missing data. When several possible models are under consideration for the data, the multiple imputation is typically performed under a single-best model selected from the candidate…

Methodology · Statistics 2018-11-30 Gyuhyeong Goh , Jae Kwang Kim

Missing value imputation is crucial for real-world data science workflows. Imputation is harder in the online setting, as it requires the imputation method itself to be able to evolve over time. For practical applications, imputation…

Machine Learning · Computer Science 2021-12-17 Yuxuan Zhao , Eric Landgrebe , Eliot Shekhtman , Madeleine Udell

Electronic Medical Records (EHR) are extremely sparse. Only a small proportion of events (symptoms, diagnoses, and treatments) are observed in the lifetime of an individual. The high degree of missingness of EHR can be attributed to a large…

Artificial Intelligence · Computer Science 2021-11-18 Ramon Vinas , Xu Zheng , Jer Hayes

Electronic healthcare records (EHR) contain a huge wealth of data that can support the prediction of clinical outcomes. EHR data is often stored and analysed using clinical codes (ICD10, SNOMED), however these can differ across registries…

Machine Learning · Computer Science 2024-12-03 Elizabeth Remfry , Rafael Henkin , Michael R Barnes , Aakanksha Naik

Missing data are often dealt with multiple imputation. A crucial part of the multiple imputation process is selecting sensible models to generate plausible values for incomplete data. A method based on posterior predictive checking is…

Computation · Statistics 2026-05-14 Mingyang Cai , Stef van Buuren , Gerko Vink

Data imputation is a critical step in data pre-processing, particularly for datasets with missing or unreliable values. This study introduces a novel quantum-inspired imputation framework evaluated on the UCI Diabetes dataset, which…

Quantum Physics · Physics 2025-05-13 Nishikanta Mohanty , Bikash K. Behera , Badshah Mukherjee , Christopher Ferrie

Urban time series, such as mobility flows, energy consumption, and pollution records, encapsulate complex urban dynamics and structures. However, data collection in each city is impeded by technical challenges such as budget limitations and…

Machine Learning · Computer Science 2025-11-26 Tong Nie , Wei Ma , Jian Sun , Yu Yang , Jiannong Cao

With medical tests becoming increasingly available, concerns about over-testing and over-treatment dramatically increase. Hence, it is important to understand the influence of testing on treatment selection in general practice. Most…

Methodology · Statistics 2020-08-11 Yun Li , Irina Bondarenko , Michael R. Elliott , Timothy P. Hofer , Jeremy M. G. Taylor

Pathology tests are central to modern healthcare in terms of diagnosis and patient management. Aggregated pathology results provide opportunities for research into fundamental and applied questions in health and medicine, but data analytic…

Applications · Statistics 2022-05-05 N. Menon , B. A. Lidbury , A. M. Richardson

Missing data is a systemic problem in practical scenarios that causes noise and bias when estimating treatment effects. This makes treatment effect estimation from data with missingness a particularly tricky endeavour. A key reason for this…

Machine Learning · Statistics 2023-02-27 Jeroen Berrevoets , Fergus Imrie , Trent Kyono , James Jordon , Mihaela van der Schaar

Handling missing data in time series is a complex problem due to the presence of temporal dependence. General-purpose imputation methods, while widely used, often distort key statistical properties of the data, such as variance and…

Methodology · Statistics 2026-03-18 Guilherme Pumi , Taiane Schaedler Prass , Douglas Krauthein Verdum

Missing data is a pervasive problem in epidemiology, with multiple imputation (MI) a commonly used analysis method. MI is valid when data are missing at random (MAR). However, definitions of MAR with multiple incomplete variables are not…

Methodology · Statistics 2025-04-14 Paul Madley-Dowd , Rachael A. Hughes , Maya B. Mathur , Jon Heron , Kate Tilling

Missing data is a common problem in medical research, and is commonly addressed using multiple imputation. Although traditional imputation methods allow for valid statistical inference when data are missing at random (MAR), their…