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Precise breast cancer classification on histopathological images has the potential to greatly improve the diagnosis and patient outcome in oncology. The data imbalance problem largely stems from the inherent imbalance within medical image…

Image and Video Processing · Electrical Eng. & Systems 2024-11-28 Majid Behzadpour , Bengie L. Ortiz , Ebrahim Azizi , Kai Wu

We present an Expectation-Maximization (EM) Regularized Deep Learning (EMReDL) model for weakly supervised tumor segmentation. The proposed framework is tailored to glioblastoma, a type of malignant tumor characterized by its diffuse…

Image and Video Processing · Electrical Eng. & Systems 2021-07-16 Chao Li , Wenjian Huang , Xi Chen , Yiran Wei , Stephen J. Price , Carola-Bibiane Schönlieb

Automatic tumor segmentation is a crucial step in medical image analysis for computer-aided diagnosis. Although the existing methods based on convolutional neural networks (CNNs) have achieved the state-of-the-art performance, many…

Image and Video Processing · Electrical Eng. & Systems 2020-05-11 Shuchao Pang , Anan Du , Mehmet A. Orgun , Yan Wang , Quanzheng Sheng , Shoujin Wang , Xiaoshui Huang , Zhemei Yu

Automatic segmentation of brain glioma from multimodal MRI scans plays a key role in clinical trials and practice. Unfortunately, manual segmentation is very challenging, time-consuming, costly, and often inaccurate despite human expertise…

Image and Video Processing · Electrical Eng. & Systems 2020-12-08 Minh H. Vu , Tufve Nyholm , Tommy Löfstedt

Gliomas appear with wide variation in their characteristics both in terms of their appearance and location on brain MR images, which makes robust tumour segmentation highly challenging, and leads to high inter-rater variability even in…

Image and Video Processing · Electrical Eng. & Systems 2021-05-25 Vaanathi Sundaresan , Ludovica Griffanti , Mark Jenkinson

Deep learning algorithms have accounted for the rapid acceleration of research in artificial intelligence in medical image analysis, interpretation, and segmentation with many potential applications across various sub disciplines in…

Image and Video Processing · Electrical Eng. & Systems 2020-12-23 Shanaka Ramesh Gunasekara , HNTK Kaldera , Maheshi B. Dissanayake

Deep learning has quickly become the weapon of choice for brain lesion segmentation. However, few existing algorithms pre-configure any biological context of their chosen segmentation tissues, and instead rely on the neural network's…

Computer Vision and Pattern Recognition · Computer Science 2017-09-12 Andrew Beers , Ken Chang , James Brown , Emmett Sartor , CP Mammen , Elizabeth Gerstner , Bruce Rosen , Jayashree Kalpathy-Cramer

We propose a weakly-supervised framework for the semantic segmentation of circular-scan synthetic-aperture-sonar (CSAS) imagery. The first part of our framework is trained in a supervised manner, on image-level labels, to uncover a set of…

Despite the superior performance of Deep Learning (DL) on numerous segmentation tasks, the DL-based approaches are notoriously overconfident about their prediction with highly polarized label probability. This is often not desirable for…

Image and Video Processing · Electrical Eng. & Systems 2021-12-14 Sungmin Hong , Anna K. Bonkhoff , Andrew Hoopes , Martin Bretzner , Markus D. Schirmer , Anne-Katrin Giese , Adrian V. Dalca , Polina Golland , Natalia S. Rost

Segmentation of tumors in brain MRI images is a challenging task, where most recent methods demand large volumes of data with pixel-level annotations, which are generally costly to obtain. In contrast, image-level annotations, where only…

Image and Video Processing · Electrical Eng. & Systems 2019-11-07 Sergey Pavlov , Alexey Artemov , Maksim Sharaev , Alexander Bernstein , Evgeny Burnaev

Accurate brain tumor segmentation from MRI scans is critical for diagnosis and treatment planning. Despite the strong performance of recent deep learning approaches, two fundamental limitations remain: (1) the lack of reliable uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Bahram Mohammadi , Yanqiu Wu , Vu Minh Hieu Phan , Sam White , Minh-Son To , Jian Yang , Michael Sheng , Yang Song , Yuankai Qi

Deep learning has shown promising results in medical image analysis, however, the lack of very large annotated datasets confines its full potential. Although transfer learning with ImageNet pre-trained classification models can alleviate…

Computer Vision and Pattern Recognition · Computer Science 2018-08-16 Ken C. L. Wong , Tanveer Syeda-Mahmood , Mehdi Moradi

The integration of machine learning in magnetic resonance imaging (MRI), specifically in neuroimaging, is proving to be incredibly effective, leading to better diagnostic accuracy, accelerated image analysis, and data-driven insights, which…

Despite deep convolutional neural networks boost the performance of image classification and segmentation in digital pathology analysis, they are usually weak in interpretability for clinical applications or require heavy annotations to…

Computer Vision and Pattern Recognition · Computer Science 2020-02-10 Yongxiang Huang , Albert C. S. Chung

Classifying the various shapes and attributes of a glioma cell nucleus is crucial for diagnosis and understanding the disease. We investigate automated classification of glioma nuclear shapes and visual attributes using Convolutional Neural…

Computer Vision and Pattern Recognition · Computer Science 2017-01-11 Veda Murthy , Le Hou , Dimitris Samaras , Tahsin M. Kurc , Joel H. Saltz

We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha

Gliomas are the most frequent primary brain tumors in adults. Glioma change detection aims at finding the relevant parts of the image that change over time. Although Deep Learning (DL) shows promising performances in similar change…

Computer Vision and Pattern Recognition · Computer Science 2023-01-27 Tommaso Di Noto , Meritxell Bach Cuadra , Chirine Atat , Eduardo Gamito Teiga , Monika Hegi , Andreas Hottinger , Patric Hagmann , Jonas Richiardi

Ultrasound-based risk stratification of thyroid nodules is a critical clinical task, but it suffers from high inter-observer variability. While many deep learning (DL) models function as "black boxes," we propose a fully automated,…

Image and Video Processing · Electrical Eng. & Systems 2025-11-18 Omar Abdelrazik , Mohamed Elsayed , Noorul Wahab , Nasir Rajpoot , Adam Shephard

Certain cancer types, notably pancreatic cancer, are difficult to detect at an early stage, motivating robust biomarker-based screening. Liquid biopsies enable non-invasive monitoring of circulating biomarkers, but typical machine learning…

Machine Learning · Computer Science 2025-11-21 Chongmin Lee , Jihie Kim

Deep learning has significantly advanced automated brain tumor diagnosis, yet clinical adoption remains limited by interpretability and computational constraints. Conventional models often act as opaque ''black boxes'' and fail to quantify…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Sepehr Salem Ghahfarokhi , M. Moein Esfahani , Raj Sunderraman , Vince Calhoun , Mohammed Alser