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Entangled networks are ubiquitous in tissues, polymers, and fabrics. However, their mechanics remain insufficiently understood due to the complexity of the topological constraints at the network level. Here, we develop a mathematical…

Soft Condensed Matter · Physics 2025-09-23 Juntao Huang , Jiabin Liu , Shaoting Lin

We study the mechanics of nematically ordered semiflexible networks showing that they, like isotropic networks, undergo an affine to non-affine cross-over controlled by the ratio of the filament length to the non-affinity length. Deep in…

Soft Condensed Matter · Physics 2010-02-25 Andrew R. Missel , Mo Bai , William S. Klug , Alex J. Levine

We find a statistical mechanism that can adjust orientations of intracellular filaments to cell geometry in absence of organizing centers. The effect is based on random and isotropic filament (de-)polymerization dynamics and is independent…

Biological Physics · Physics 2015-05-28 Philip Greulich , Ludger Santen

We study the elasticity of random fiber networks. Starting from a microscopic picture of the non-affine deformation fields we calculate the macroscopic elastic moduli both in a scaling theory and a self-consistent effective medium theory.…

Soft Condensed Matter · Physics 2016-08-31 Claus Heussinger , Erwin Frey

We develop an effective medium approach to the mechanics of disordered, semiflexible polymer networks and study the response of such networks to uniform and nonuniform strain. We identify distinct elastic regimes in which the contributions…

Soft Condensed Matter · Physics 2009-11-11 Moumita Das , F. C. MacKintosh , Alex Levine

Filamentous bio-materials such as fibrin or collagen networks exhibit an enormous stiffening of their elastic moduli upon large deformations. This pronounced nonlinear behavior stems from a significant separation between the stiffnesses…

Soft Condensed Matter · Physics 2019-05-21 Robbie Rens , Carlos Villarroel , Gustavo Düring , Edan Lerner

While actin bundles are used by living cells for structural fortification, the microscopic origin of the elasticity of bundled networks is not understood. Here, we show that above a critical concentration of the actin binding protein…

Soft Condensed Matter · Physics 2007-08-30 O. Lieleg , M. M. A. E. Claessens , C. Heussinger , E. Frey , A. R. Bausch

Networks of filamentous proteins play a crucial role in cell mechanics. These cytoskeletal networks, together with various crosslinking and other associated proteins largely determine the (visco)elastic response of cells. In this letter we…

Disordered Systems and Neural Networks · Physics 2009-11-10 D. A. Head , A. J. Levine , F. C. MacKintosh

Cells moving on a two dimensional substrate generate motion by polymerizing actin filament networks inside a flat membrane protrusion. New filaments are generated by branching off existing ones, giving rise to branched network structures.…

Biological Physics · Physics 2015-06-29 Mohammadhosein Razbin , Martin Falcke , Panayotis Benetatos , Annette Zippelius

Entangled networks of stiff biopolymers exhibit complex dynamic response, emerging from the topological constraints that neighboring filaments impose upon each other. We propose a class of reference models for entanglement dynamics of stiff…

Soft Condensed Matter · Physics 2008-06-23 Felix Höfling , Tobias Munk , Erwin Frey , Thomas Franosch

Disordered soft materials, such as fibrous networks in biological contexts exhibit a nonlinear elastic response. We study such nonlinear behavior with a minimal model for networks on lattice geometries with simple Hookian elements with…

Soft Condensed Matter · Physics 2015-03-13 M. Sheinman , C. P. Broedersz , F. C. MacKintosh

The rigidity of elastic networks depends sensitively on their internal connectivity and the nature of the interactions between constituents. Particles interacting via central forces undergo a zero-temperature rigidity-percolation transition…

Soft Condensed Matter · Physics 2011-12-08 Chase P. Broedersz , Xiaoming Mao , T. C. Lubensky , F. C. MacKintosh

The cytoskeleton of eukaryotic cells provides mechanical support and governs intracellular transport. These functions rely on the complex mechanical properties of networks of semiflexible protein filaments. Recent theoretical interest has…

Soft Condensed Matter · Physics 2012-11-01 M. Atakhorrami , G. H. Koenderink , J. F. Palierne , F. C. MacKintosh , C. F. Schmidt

Athermal models of disordered fibrous networks are highly useful for studying the mechanics of elastic networks composed of stiff biopolymers. The underlying network architecture is a key aspect that can affect the elastic properties of…

Soft Condensed Matter · Physics 2016-01-20 Albert James Licup , Abhinav Sharma , Fred C. MacKintosh

Experiments have shown that elasticity of disordered filamentous networks with compliant crosslinks is very different from networks with rigid crosslinks. Here, we model and analyze filamentous networks as a collection of randomly oriented…

Biological Physics · Physics 2015-06-17 A. Sharma , M. Sheinman , K. M. Heidemann , F. C. MacKintosh

Cells exert traction forces on compliant substrates and can induce surface instabilities that appear as characteristic wrinkling patterns. Here, we develop a mechanical description of cell-induced wrinkling on soft substrates using a thin…

Soft Condensed Matter · Physics 2026-03-16 Aleksandra Ardaševa , Varun Venkatesh , Daiki Matsunaga , Shinji Deguchi , Amin Doostmohammadi

Collagen is the main structural and load-bearing element of various connective tissues, where it forms the extracellular matrix that supports cells. It has long been known that collagenous tissues exhibit a highly nonlinear stress-strain…

Biological cells embedded in fibrous matrices have been observed to form inter-cellular bands of dense and aligned fibers, through which they mechanically interact over long distances. Such matrix-mediated cellular interactions have been…

Biological Physics · Physics 2018-11-14 Ran S Sopher , Hanan Tokash , Sari Natan , Mirit Sharabi , Ortal Shelah , Oren Tchaicheeyan , Ayelet Lesman

Living matter moves, deforms, and organizes itself. In cells this is made possible by networks of polymer filaments and crosslinking molecules that connect filaments to each other and that act as motors to do mechanical work on the network.…

Soft Condensed Matter · Physics 2020-12-15 Sebastian Fürthauer , Daniel J Needleman , Michael J. Shelley

We study the elasticity of fibrous materials composed of generalized stiff polymers. It is shown that in contrast to cellular foam-like structures affine strain fields are generically unstable. Instead, a subtle interplay between the…

Soft Condensed Matter · Physics 2007-05-23 Claus Heussinger , Erwin Frey
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