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Influenza poses a significant threat to public health, particularly among the elderly, young children, and people with underlying dis-eases. The manifestation of severe conditions, such as pneumonia, highlights the importance of preventing…

Machine Learning · Computer Science 2024-02-23 Yanhua Xu , Dominik Wojtczak

Influenza viruses mutate rapidly and can pose a threat to public health, especially to those in vulnerable groups. Throughout history, influenza A viruses have caused pandemics between different species. It is important to identify the…

Machine Learning · Computer Science 2024-05-24 Yanhua Xu , Dominik Wojtczak

The Influenza type A virus can be considered as one of the most severe viruses that can infect multiple species with often fatal consequences to the hosts. The Haemagglutinin (HA) gene of the virus has the potential to be a target for…

Quantitative Methods · Quantitative Biology 2021-02-16 Charalambos Chrysostomou , Harris Partaourides , Huseyin Seker

The Influenza virus can be considered as one of the most severe viruses that can infect multiple species with often fatal consequences to the hosts. The Hemagglutinin (HA) gene of the virus can be a target for antiviral drug development…

Quantitative Methods · Quantitative Biology 2021-08-11 Charalambos Chrysostomou , Floris Alexandrou , Mihalis A. Nicolaou , Huseyin Seker

Influenza is an infectious disease with the potential to become a pandemic, and hence, forecasting its prevalence is an important undertaking for planning an effective response. Research has found that web search activity can be used to…

Machine Learning · Computer Science 2021-05-27 Michael Morris , Peter Hayes , Ingemar J. Cox , Vasileios Lampos

The Influenza A virus belongs to the Orthomyxoviridae family. Influenza virus infection occurs yearly in all countries of the world. It usually kills between 250,000 and 500,000 people and causes severe illness in millions more. Over the…

Cell Behavior · Quantitative Biology 2014-11-25 Juliana Silva Capitanio , Richard W. Wozniak

Public health surveillance systems often fail to detect emerging infectious diseases, particularly in resource limited settings. By integrating relevant clinical and internet-source data, we can close critical gaps in coverage and…

Applications · Statistics 2019-03-05 Kai Liu , Ravi Srinivasan , Lauren Ancel Meyers

Determining phenotype from genetic data is a fundamental challenge. Influenza A viruses undergo rapid antigenic drift and identification of emerging antigenic variants is critical to the vaccine selection process. Using former seasonal…

A central challenge in every field of biology is to use existing measurements to predict the outcomes of future experiments. In this work, we consider the wealth of antibody inhibition data against variants of the influenza virus. Due to…

Quantitative Methods · Quantitative Biology 2023-07-27 Tal Einav , Rong Ma

The influenza virus hemagglutinin is an important part of the virus attachment to the host cells. The hemagglutinin proteins are one of the genetic regions of the virus with a high potential for mutations. Due to the importance of…

Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between…

Infectious diseases pose significant human and economic burdens. Accurately forecasting disease incidence can enable public health agencies to respond effectively to existing or emerging diseases. Despite progress in the field, developing…

Machine Learning · Computer Science 2024-09-04 Michael Morris

Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA) and…

Populations and Evolution · Quantitative Biology 2016-04-27 Richard A. Neher , Trevor Bedford , Rodney S. Daniels , Colin A. Russell , Boris I. Shraiman

Influenza, an infectious disease, causes many deaths worldwide. Predicting influenza victims during epidemics is an important task for clinical, hospital, and community outbreak preparation. On-line user-generated contents (UGC), primarily…

Computers and Society · Computer Science 2021-04-15 Taichi Murayama , Nobuyuki Shimizu , Sumio Fujita , Shoko Wakamiya , Eiji Aramaki

Analyses and visualizations by the ISSCOR method of influenza virus hemagglutinin genes of different A-subtypes revealed some rather striking temporal relationships between groups of individual gene subsets. Based on these findings we…

Genomics · Quantitative Biology 2013-11-11 Jan P. Radomski , Piotr P. Slonimski , Włodzimierz Zagórski-Ostoja , Piotr Borowicz

The accurate forecasting of infectious epidemic diseases such as influenza is a crucial task undertaken by medical institutions. Although numerous flu forecasting methods and models based mainly on historical flu activity data and online…

Machine Learning · Computer Science 2021-07-08 Taichi Murayama , Shoko Wakamiya , Eiji Aramaki

Background: Early forecasts of dengue are an important tool for disease mitigation. Neural networks are powerful predictive models that have made contributions to many areas of public health. In this study, we reviewed the application of…

Machine Learning · Computer Science 2025-12-19 Luiza Lober , Francisco A. Rodrigues , Kirstin Roster

Predicting cross-immunity between viral strains is vital for public health surveillance and vaccine development. Traditional neural network methods, such as BiLSTM, could be ineffective due to the lack of lab data for model training and the…

Computational Engineering, Finance, and Science · Computer Science 2023-10-18 Yiming Du , Zhuotian Li , Qian He , Thomas Wetere Tulu , Kei Hang Katie Chan , Lin Wang , Sen Pei , Zhanwei Du , Xiao-Ke Xu , Xiao Fan Liu

High order structures (cavities and cliques) of the gene network of influenza A virus reveal tight associations among viruses during evolution and are key signals that indicate viral cross-species infection and cause pandemics. As…

Genomics · Quantitative Biology 2022-11-08 Junjie Li , Jietong Zhao , Yanqing Su , Jiahao Shen , Yaohua Liu , Xinyue Fan , Zheng Kou

Accurate epidemic forecasting is critical for informing public health decisions and timely interventions. While Physics-Informed Neural Networks have shown promise in various scientific domains, their potential application to real-time…

Physics and Society · Physics 2026-05-20 Martina Rama , Gabriele Santin , Giulia Cencetti , Michele Tizzoni , Bruno Lepri
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