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Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein functions. Recent sequence representation learning methods based on Protein Language Models (PLMs) excel in sequence-based…

Quantitative Methods · Quantitative Biology 2023-10-19 Zuobai Zhang , Chuanrui Wang , Minghao Xu , Vijil Chenthamarakshan , Aurélie Lozano , Payel Das , Jian Tang

Network representation learning has aroused widespread interests in recent years. While most of the existing methods deal with edges as pairwise relationships, only a few studies have been proposed for hyper-networks to capture more…

Social and Information Networks · Computer Science 2019-10-23 Jie Huang , Xin Liu , Yangqiu Song

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein function or structure. Existing approaches usually pretrain protein language models on a large number of unlabeled amino acid…

Machine Learning · Computer Science 2023-01-31 Zuobai Zhang , Minghao Xu , Arian Jamasb , Vijil Chenthamarakshan , Aurelie Lozano , Payel Das , Jian Tang

Link prediction is critical for the application of incomplete knowledge graph (KG) in the downstream tasks. As a family of effective approaches for link predictions, embedding methods try to learn low-rank representations for both entities…

Computation and Language · Computer Science 2019-11-22 Canran Xu , Ruijiang Li

Since large knowledge bases are typically incomplete, missing facts need to be inferred from observed facts in a task called knowledge base completion. The most successful approaches to this task have typically explored explicit paths…

Artificial Intelligence · Computer Science 2018-04-24 Yelong Shen , Po-Sen Huang , Ming-Wei Chang , Jianfeng Gao

How can we effectively and efficiently learn node representations in signed bipartite graphs? A signed bipartite graph is a graph consisting of two nodes sets where nodes of different types are positively or negative connected, and it has…

Machine Learning · Computer Science 2024-12-30 Gyeongmin Gu , Minseo Jeon , Hyun-Je Song , Jinhong Jung

We present a method for finding hierarchy-aware embeddings of knowledge graphs (KGs) using graph neural networks (GNNs) enriched with a semantic loss derived from underlying ontologies. This method yields embeddings that better reflect…

Machine Learning · Computer Science 2026-05-21 Filip Kronström , Alexander H. Gower , Daniel Brunnsåker , Ievgeniia A. Tiukova , Ross D. King

Exploring the effects a chemical compound has on a species takes a considerable experimental effort. Appropriate methods for estimating and suggesting new effects can dramatically reduce the work needed to be done by a laboratory. In this…

Artificial Intelligence · Computer Science 2019-11-12 Erik Bryhn Myklebust , Ernesto Jimenez-Ruiz , Jiaoyan Chen , Raoul Wolf , Knut Erik Tollefsen

3D skeleton-based action recognition and motion prediction are two essential problems of human activity understanding. In many previous works: 1) they studied two tasks separately, neglecting internal correlations; 2) they did not capture…

Computer Vision and Pattern Recognition · Computer Science 2019-10-08 Maosen Li , Siheng Chen , Xu Chen , Ya Zhang , Yanfeng Wang , Qi Tian

3D human pose estimation is a difficult task, due to challenges such as occluded body parts and ambiguous poses. Graph convolutional networks encode the structural information of the human skeleton in the form of an adjacency matrix, which…

Computer Vision and Pattern Recognition · Computer Science 2022-12-14 Soubarna Banik , Alejandro Mendoza Gracia , Alois Knoll

Machine learning (ML) is revolutionizing protein structural analysis, including an important subproblem of predicting protein residue contact maps, i.e., which amino-acid residues are in close spatial proximity given the amino-acid sequence…

Quantitative Methods · Quantitative Biology 2022-12-23 Kuang Liu , Rajiv K. Kalia , Xinlian Liu , Aiichiro Nakano , Ken-ichi Nomura , Priya Vashishta , Rafael Zamora-Resendizc

Biological systems are governed by structured molecular interactions, where pathways, regulatory circuits, and functional gene relationships shape cellular behavior and disease progression. Much of this knowledge is naturally represented as…

Machine Learning · Computer Science 2026-05-26 Yuwei Xue , Sakib Mostafa , James Zou , Joseph Liao , Maximilian Diehn , Ash A. Alizadeh , Lei Xing , Md. Tauhidul Islam

Capturing the composition patterns of relations is a vital task in knowledge graph completion. It also serves as a fundamental step towards multi-hop reasoning over learned knowledge. Previously, several rotation-based translational methods…

Artificial Intelligence · Computer Science 2022-01-12 Haonan Lu , Hailin Hu , Xiaodong Lin

In this paper, we study the problem of learning continuous vector representations of knowledge graphs for predicting missing links. We present a new approach called ConEx, which infers missing links by leveraging the composition of a 2D…

Machine Learning · Computer Science 2021-06-10 Caglar Demir , Axel-Cyrille Ngonga Ngomo

Link prediction is the task of inferring missing links between entities in knowledge graphs. Embedding-based methods have shown effectiveness in addressing this problem by modeling relational patterns in triples. However, the link…

Computation and Language · Computer Science 2024-03-05 Miao Peng , Ben Liu , Qianqian Xie , Wenjie Xu , Hua Wang , Min Peng

We participated in three of the protein-protein interaction subtasks of the Second BioCreative Challenge: classification of abstracts relevant for protein-protein interaction (IAS), discovery of protein pairs (IPS) and text passages…

Conventional Knowledge Graph Completion (KGC) assumes that all test entities appear during training. However, in real-world scenarios, Knowledge Graphs (KG) evolve fast with out-of-knowledge-graph (OOKG) entities added frequently, and we…

Computation and Language · Computer Science 2020-09-29 Damai Dai , Hua Zheng , Fuli Luo , Pengcheng Yang , Baobao Chang , Zhifang Sui

An emerging trend in representation learning over knowledge graphs (KGs) moves beyond transductive link prediction tasks over a fixed set of known entities in favor of inductive tasks that imply training on one graph and performing…

Machine Learning · Computer Science 2022-04-20 Mikhail Galkin , Max Berrendorf , Charles Tapley Hoyt

Predicting missing links between entities in a knowledge graph is a fundamental task to deal with the incompleteness of data on the Web. Knowledge graph embeddings map nodes into a vector space to predict new links, scoring them according…

Artificial Intelligence · Computer Science 2023-02-14 Cosimo Gregucci , Mojtaba Nayyeri , Daniel Hernández , Steffen Staab

Motivation: In the last few years a growing interest in biology has been shifting towards the problem of optimal information extraction from the huge amount of data generated via large scale and high-throughput techniques. One of the most…

Quantitative Methods · Quantitative Biology 2007-05-23 M. Leone , A. Pagnani