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A crucial step in the early development of multicellular organisms involves the establishment of spatial patterns of gene expression which later direct proliferating cells to take on different cell fates. These patterns enable the cells to…

Molecular Networks · Quantitative Biology 2017-02-08 Patrick Hillenbrand , Ulrich Gerland , Gasper Tkacik

In this work we investigate the effect of density dependent nonlinear diffusion on pattern formation in the Brusselator system. Through linear stability analysis of the basic solution we determine the Turing and the oscillatory instability…

Mathematical Physics · Physics 2015-06-17 G. Gambino , M. C. Lombardo , M. Sammartino , V. Sciacca

The past decade has witnessed the development of systematic effective theories for dissipative thermal systems. Here, we describe an analogous effective theory framework that applies to the classical stochastic dynamics of nonequilibrium…

Statistical Mechanics · Physics 2023-10-20 Xiaoyang Huang , Jack H. Farrell , Aaron J. Friedman , Isabella Zane , Paolo Glorioso , Andrew Lucas

This paper investigates pattern formation in reaction--diffusion systems with both diffusive and nondiffusive components, providing necessary and sufficient conditions for diffusion-driven instability (DDI) and establishing the existence of…

Analysis of PDEs · Mathematics 2026-05-07 Théo André , Szymon Cygan , Anna Marciniak-Czochra , Finn Münnich

Biological systems are majorly dependent on their property of bistability in order to exhibit nongenetic heterogeneity in terms of cellular morphology and physiology. Spatial patterns of phenotypically heterogeneous cells, arising due to…

Quantitative Methods · Quantitative Biology 2023-01-25 Priya Chakraborty , Ushasi Roy , Mohit K. Jolly , Sayantari Ghosh

Linear diffusion processes serve as canonical continuous-time models for dynamic decision-making under uncertainty. These systems evolve according to drift matrices that specify the instantaneous rates of change in the expected system…

Machine Learning · Computer Science 2025-06-10 Mohamad Kazem Shirani Faradonbeh , Sadegh Shirani , Mohsen Bayati

Development of thermodynamic induction up to second order gives a dynamical bifurcation for thermodynamic variables and allows for the prediction and detailed explanation of nonequilibrium phase transitions with associated spontaneous…

Statistical Mechanics · Physics 2021-10-07 S. N. Patitsas

Temperature gradients represent energy sources that can be harvested to generate steady reaction or transport fluxes. Technological developments could lead to the transfer of free energy from heat sources and sinks to chemical systems for…

Chemical Physics · Physics 2025-03-13 Mohammed Loukili , Ludovic Jullien , Guillaume Baffou , Raphaël Plasson

Minimization of energy in gradient systems leads to formation of oscillatory and Turing patterns in reaction-diffusion systems. These patterns should be accurately computed using fine space and time meshes over long time horizons to reach…

Numerical Analysis · Mathematics 2018-11-28 Tuğba Akman Yıldız , Murat Uzunca , Bülent Karasözen

Analytically tracking patterns emerging from a small amplitude Turing instability to large amplitude remains a challenge as no general theory exists. In this paper, we consider a three component reaction-diffusion system with one of its…

Dynamical Systems · Mathematics 2023-11-06 Christopher Brown , Gianne Derks , Peter van Heijster , David J. B. Lloyd

The nonexponential relaxation and aging inherent to complex dynamics manifested in a wide variety of dissipative systems is analyzed through a model of diffusion in phase space in the presence of a nonconservative force. The action of this…

Statistical Mechanics · Physics 2009-11-11 A. Perez-Madrid

We present the exact solution for the full dynamics of a nonequilibrium spin chain and its dual reaction-diffusion model, for arbitrary initial conditions. The spin chain is driven out of equilibrium by coupling alternating spins to two…

Statistical Mechanics · Physics 2007-05-23 M. Mobilia , B. Schmittmann , R. K. P. Zia

Organisms are nonequilibrium, stationary systems self-organized via spontaneous symmetry breaking and undergoing metabolic cycles with broken detailed balance in the environment. The thermodynamic free-energy principle describes an…

Neurons and Cognition · Quantitative Biology 2022-11-24 Chang Sub Kim

The thermal dynamics in thermo-mechanical systems exhibits a much slower time scale compared to the structural dynamics. In this work, we use the method of multiple scales to reduce the thermo-mechanical structural models with a…

Computational Engineering, Finance, and Science · Computer Science 2019-10-25 Shobhit Jain , Paolo Tiso

Many chemical reactions can be formulated in terms of particle diffusion in a complex energy landscape. Transition path theory (TPT) is a theoretical framework for describing the direct (reaction) pathways from reactant to product states…

Statistical Mechanics · Physics 2023-10-03 Paul C Bressloff

When a system is in equilibrium, external perturbations yield a time series of non-equilibrium distributions, and recent experimental techniques give access to the non-equilibrium data that may contain critical information. Jinwoo and…

Statistical Mechanics · Physics 2023-01-16 Lee Jinwoo

We study the asymptotic behaviour of a system of nonlinear reaction--diffusion--advection equations in a domain consisting of two bulk regions connected via microscopic channels distributed within a thin membrane. Both the width of the…

Analysis of PDEs · Mathematics 2025-12-15 Lucas M. Fix , Gianna Götzmann , Malte A. Peter , Jan-F. Pietschmann

Mathematical modeling is now used commonly in the analysis of signaling networks. With advances in high resolution microscopy, the spatial location of different signaling molecules and the spatio-temporal dynamics of signaling microdomains…

Subcellular Processes · Quantitative Biology 2016-07-26 Jasmine Nirody , Padmini Rangamani

Most natural systems operate far from equilibrium, displaying time-asymmetric, irreversible dynamics characterized by a positive entropy production while exchanging energy and matter with the environment. Although stochastic thermodynamics…

Statistical Mechanics · Physics 2023-06-27 Miguel Aguilera , Masanao Igarashi , Hideaki Shimazaki

Reaction-diffusion systems with time-delay defined on complex networks have been studied in the framework of the emergence of Turing instabilities. The use of the Lambert W-function allowed us get explicit analytic conditions for the onset…

Statistical Mechanics · Physics 2016-08-03 Julien Petit , Malbor Asllani , Duccio Fanelli , Ben Lauwens , Timoteo Carletti